Genetic Programming of Hypertension

The heritability of hypertension (HTN) is widely recognized and as a result, extensive studies ranging from genetic linkage analyses to genome-wide association studies are actively ongoing to elucidate the etiology of both monogenic and polygenic forms of HTN. Due to the complex nature of essential HTN, however, single genes affecting blood pressure (BP) variability remain difficult to isolate and identify and have rendered the development of single-gene targeted therapies challenging. The roles of other causative factors in modulating BP, such as gene–environment interactions and epigenetic factors, are increasingly being brought to the forefront. In this review, we discuss the various monogenic HTN syndromes and corresponding pathophysiologic mechanisms, the different methodologies employed in genetic studies of essential HTN, the mechanisms for epigenetic modulation of essential HTN, pharmacogenomics and HTN, and finally, recent advances in genetic studies of essential HTN in the pediatric population

Unmasking the Phantoms of Generations: A Comparative Study of Financial Responsibility and Stress Across Generational Divides (FTA Best Paper Award)

This study investigated whether financial stress is associated with experiencing the COVID-19 pandemic across different generations. In addition, this research examined whether financial payment behaviors are associated with experiencing the COVID-19 pandemic, different generations, and having higher financial stress. Two cross-sectional samples were collected from the United States at two time points, before COVID-19 (n = 823) and during COVID-19 (n = 803). Ordinary least squared (OLS) regression and ordered logistic models were utilized to answer the research questions. The results revealed that COVID-19 increased financial stress, but the younger generations have demonstrated resilience in dealing with the pandemic, contrary to previous research. Furthermore, when analyzing specific financial payment behavior trends such as responsible behavior, continuous age values were found to be more significant than generational divisions. Consequently, the results indicated financial stress related to the COVID-19 pandemic, but it was not associated with generational categories. Both academic and practical implications of the findings are discussed

AUTOMATIC ACTIVATION OF SEMANTIC REPRESENTATION DURING SECOND LANGUAGE PROCESSING

The present study is motivated by two questions. First, can late learners of a second language (L2), who begin learning after puberty and are unbalanced bilinguals, activate or visualize the meaning of an L2 word or sentence as quickly as do first language (L1) speakers? Second, if so, what factors—such as L2 proficiency and the amount of its use—contribute to developing native–like efficient processing in L2? To address these questions, the degrees of automatic semantic activation were compared between L1 and L2 speakers through emotional involvement during word recognition and mental imagery generation during sentential reading. To this end, a total of 60 late–advanced L2 Korean speakers participated in the emotional Stroop Task and the sentence–based picture recognition task along with 36 L1 Korean speakers. The results revealed that the emotional Stroop effect was not statistically significant in the late L2 group but was significant in the L1 group; whereas the sentence–picture congruency effect was significant in both L2 and L1 groups with similar degrees. This means that late L2 Korean speakers could activate sentence meaning during L2 sentential reading as automatically as L1 speakers but could not activate word meaning as efficiently as L1 speakers. Different degrees of semantic activation among the L2 group across experiments compared to L1 speakers can be considered as cross–task variation; that is, L2 speakers exhibited native–like patterns when semantic activation was promoted but did not when constrained in the tasks (in a sentence–based picture recognition task and an emotional Stroop task, respectively). Furthermore, the results showed that the effect of L2 use was positively significant both on the emotional Stroop effect and the sentence–picture congruency effect. These findings suggest that the degree of automatic semantic activation during L2 word recognition, as well as sentence reading can be improved with increased L2 use, despite the late starting age of L2 acquisition. Overall, the present study found positive evidence that late L2 speakers may achieve native–like efficiency in reading comprehension in L2, assisted with the extensive L2 use in addition to high proficiency in L2

Ultrahigh areal number density solid-state on-chip microsupercapacitors via electrohydrodynamic jet printing

Microsupercapacitors (MSCs) have garnered considerable attention as a promising power source for microelectronics and miniaturized portable/wearable devices. However, their practical application has been hindered by the manufacturing complexity and dimensional limits. Here, we develop a new class of ultrahigh areal number density solid-state MSCs (UHD SS-MSCs) on a chip via electrohydrodynamic (EHD) jet printing. This is, to the best of our knowledge, the first study to exploit EHD jet printing in the MSCs. The activated carbon-based electrode inks are EHD jet-printed, creating interdigitated electrodes with fine feature sizes. Subsequently, a drying-free, ultraviolet-cured solid-state gel electrolyte is introduced to ensure electrochemical isolation between the SS-MSCs, enabling dense SS-MSC integration with on-demand (in-series/in-parallel) cell connection on a chip. The resulting on-chip UHD SS-MSCs exhibit exceptional areal number density [36 unit cells integrated on a chip (area = 8.0 mm x 8.2 mm), 54.9 cells cm(-2)] and areal operating voltage (65.9 V cm(-2))

The Theory of Falling Shadows Applied to -Ideals in -Algebras

On the basis of the theory of a falling shadow which was first formulated by Wang (1985), the notion of falling ∗-ideals in -algebras is introduced, and related properties are investigated. Characterizations of a falling ∗-ideal are established. Relations among falling ∗-ideals, falling -ideals, falling #-ideals, falling -subalgebras, and falling BCK-ideals are discussed

Human microglial cells synthesize albumin in brain

Albumin has been implicated in Alzheimer's disease since it can bind to and transport amyloid beta, the causative agent; albumin is also a potent inhibitor of amyloid beta polymerization. In a pilot phase study of Human Brain Proteome Project, we found evidence that albumin may be synthesized in immortalized human microglial cells, human primary microglial cells, and human fetal and adult brain tissues. We also found the synthesis and secretion is enhanced upon microglial activation by Amyloid [beta]~1-42~, lipopolysaccharide treatment or human Alzheimer's brain