Molecular aspects of MERS-CoV

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Middle East respiratory syndrome coronavirus (MERS-CoV) is a betacoronavirus which can cause acute respiratory distress in humans and is associated with a relatively high mortality rate. Since it was first identified in a patient who died in a Jeddah hospital in 2012, the World Health Organization has been notified of 1735 laboratory-confirmed cases from 27 countries, including 628 deaths. Most cases have occurred in Saudi Arabia. MERS-CoVancestors may be found in OldWorld bats of the Vespertilionidae family. After a proposed bat to camel switching event, transmission of MERS-CoV to humans is likely to have been the result of multiple zoonotic transfers from dromedary camels. Human-to-human transmission appears to require close contact with infected persons, with outbreaks mainly occurring in hospital environments. Outbreaks have been associated with inadequate infection prevention and control implementation, resulting in recommendations on basic and more advanced infection prevention and control measures by the World Health Organization, and issuing of government guidelines based on these recommendations in affected countries including Saudi Arabia. Evolutionary changes in the virus, particularly in the viral spike protein which mediates virus-host cell contact may potentially increase transmission of this virus. Efforts are on-going to identify specific evidence-based therapies or vaccines. The broad-spectrum antiviral nitazoxanide has been shown to have in vitro activity against MERS-CoV. Synthetic peptides and candidate vaccines based on regions of the spike protein have shown promise in rodent and non-human primate models. GLS-5300, a prophylactic DNA-plasmid vaccine encoding S protein, is the first MERS-CoV vaccine to be tested in humans, while monoclonal antibody, m336 has given promising results in animal models and has potential for use in outbreak situations

Contributing Factors to Under-Five Child Malnutrition in Rural Bangladesh

Background and objectives: Bangladesh has the highest malnutrition rates in the world. The main objective of this study is to identify and determine the main factors for child malnutrition among children under the age 5 years in rural Bangladesh. Material and methods: This research was conducted in rural areas at Meherpur district in Bangladesh. Convenience sampling method is used and 85 under 5 child information is collected through a structured questionnaire. The information’s of child’s are gathered from the mothers of the child. Malnourished children is measured by using APLS method and WHO Child Growth Standard Median Index. Binary logistic regression model is used to find out the key factors of malnutrition. Results: It is found that family income, maintain proper diet during pregnancy period, proper diet maintain for children have negative significant (p\u3c0.05) effect on child malnutrition. Conclusion: The magnitude of the child’s malnutrition still is of great concern in Bangladesh. Since, poverty, imbalanced diet during pregnancy period and imbalanced diet for under 5 children influences to malnutrition are significantly associated with high prevalence of malnutrition, so government and people should reduce these factor to reduce malnutrition in rural area of Bangladesh

Remifentanil vs dexmedetomidine for severely preeclamptic parturients scheduled for cesarean section under general anesthesia: A randomized controlled trial

AbstractObjectivesTo compare the effect of remifentanil vs dexmedetomidine on hemodynamic response of noxious stimuli and neonatal outcome in preeclamptic parturient underwent C.S. under G.A.MethodsThis blinded, prospective, randomized trial included 50 preeclamptic parturients underwent C.S under G.A., randomized into two equal groups [25 patients each]: group R [remifentanil]: received 1μg/kg loading and 0.05μg/kg/min infusion doses and group D [dexmedetomidine] received 1/kg loading and 0.2μg/kg/h infusion doses. Maternal MAP and HR were assessed before medication (T0), just after induction of GA (TI), just after intubation (TT), two minutes after intubation (TT2), just after skin incision (TS), two minutes after skin incision (TS2), just after delivery of the baby (TD), and at the end of operation (TE). Time between induction and fetal delivery (I-D interval), time between incision of the uterus and delivery (U-D interval), and time between stop of the infusion of the tested drugs and delivery (D-D interval) were recorded. Neonatal Apgar score was recorded at 1 and 5min and the need for resuscitative measures.ResultsMaternal MAP and HR in group R were statistically lower at (TI), (TT), (TT2), (TS) and (TS2). Neonatal Apgar score was statistically lower in group R with higher incidence for tactile stimulation.ConclusionBoth remifentanil and dexmedetomidine were effective on blunting the pressor response to noxious stimuli in severely preeclamptic parturients. While remifentanil was marginally more effective in suppressing the pressor response, dexmedetomidine was safer for the neonates

Frequency of Glomerular Dysfunction in Children with Beta Thalassaemia Major

Objectives: This study investigated the frequency of glomerular dysfunction in children with beta thalassaemia major (β-TM) by using different markers and correlating them with serum ferritin and iron chelation therapy. Methods: The study, carried out between August 2011 and May 2012, included 100 patients with β-TM, in two groups. Group Ia (n = 62) received chelation therapy (deferoxamine). Group Ib (n = 38) received followup care at the Pediatric Hematology Outpatient Clinic, Minia University Children’s Hospital, Egypt. Group II included 50 apparently healthy controls, age- and sex-matched to Group I. All patients underwent a thorough history-taking, clinical examination and laboratory investigations. Results: Compared to Group II, Groups Ia and Ib had significantly higher levels of cystatin C, serum creatinine and serum ferritin, and a higher albumin/ creatinine ratio in their urine, and a significantly lower estimated glomerular filtration rate (eGFR) and creatinine clearance (P <0.05). Moreover, Group Ιa had a significantly lower eGFR and creatinine clearance than Group Ib. Cystatin C had a highly significant strong negative correlation with eGFR and creatinine clearance and a significantly strong positive correlation with serum ferritin, and a higher sensitivity and specificity than serum creatinine and creatinine clearance for small changes in GFR. Conclusion: β-TM patients had a high frequency of glomerular dysfunction—possibly attributable to chronic anaemia, iron overload or chelation therapy. Periodic renal assessment is mandatory to detect renal complications. Cystatin C is a promising marker to monitor glomerular dysfunction, having a higher sensitivity and specificity than serum creatinine and creatinine clearance for small changes in GFR

Adenosine A2A Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism

Pharmacological studies implicate the blockade of adenosine receptorsas an effective strategy for reducing Parkinson’s disease (PD) symptoms. The objective of this study is to elucidate the possible protective effects of ZM241385 and 8-cyclopentyl-1, 3-dipropylxanthine, two selective A2A and A1 receptor antagonists, on a rotenone rat model of PD. Rats were split into four groups: vehicle control (1 ml/kg/48 h), rotenone (1.5 mg/kg/48 h, s.c.), ZM241385 (3.3 mg/kg/day, i.p) and 8-cyclopentyl-1, 3-dipropylxanthine (5 mg/kg/day, i.p). After that, animals were subjected to behavioral (stride length and grid walking) and biochemical (measuring concentration of dopamine levels using high performance liquid chromatography, HPLC). In the rotenone group, rats displayed a reduced motor activity and disturbed movement coordination in the behavioral tests and a decreased dopamine concentration as foundby HPLC. The effect of rotenone was partially prevented in the ZM241385 group, but not with 8-cyclopentyl-1,3-dipropylxanthine administration. The administration of ZM241385 improved motor function and movement coordination (partial increase of stride length and partial decrease in the number of foot slips) and an increase in dopamine concentration in the rotenone-injected rats. However, the 8-cyclopentyl-1,3-dipropylxanthine and rotenone groups were not significantly different. These results indicate that selective A2A receptor blockade by ZM241385, but not A1 receptor blockadeby 8-cyclopentyl-1,3-dipropylxanthine, may treat PD motor symptoms. This reinforces the potential use of A2A receptor antagonists as a treatment strategy for PD patients

Fourth-generation SM imprints in B -> K^*l^+l^- decays with polarized K^*

The implication of the fourth-generation quarks in the B -> K^*l^+l^- (l=mu,tau) decays, when K^* meson is longitudinally or transversely polarized, is presented. In this context, the dependence of the branching ratio with polarized K^* and the helicity fractions (f_{L,T}) of K^* meson are studied. It is observed that the polarized branching ratios as well as helicity fractions are sensitive to the NP parameters, especially when the final state leptons are tauons. Hence the measurements of these observables at LHC can serve as a good tool to investigate the indirect searches of new physics beyond the Standard Model.Comment: 13 pages, 10 figures, V2: some of the graphs are modified according to the new data from recent experiments. arXiv admin note: substantial text overlap with arXiv:1107.569

Comparison of magnetized and normal water on yield and yield components of banana and hydraulic performance of drip irrigation system

     An experiment was conducted at the Horticultural Research Centre Farm of the Agricultural Research Corporation (ARC), Wad Medani, Sudan during seasons 2010 through 2012 to evaluate effects of magnetic water technology on yield, and yield components of banana cv. Albeily and hydraulics of drip irrigation system. Two types of irrigation water were used: magnetic water and normal water. The plot of each type of irrigation water consisted of 4 banana plants. The two treatments were replicated 5 times. The results revealed that applying magnetic water increased plant height and girth of banana and attained fewer days from planting to flowering and from flowering to harvest compared to normal water. Bunch weight and number of hands per bunch were also higher for magnetic water.  Magnetic water improved the hydraulic performance of drip irrigation system compared to normal water.        اجريت هذه الدراسة بمزرعة مركز بحوث البساتين، هيئة البحوث الزراعية، واد مدني السودان في الفترة من 2010 وحتي 2012 لتقييم أثر تقنية مغنطة المياه على الانتاجية  ومكونات انتاجية الموز والاداء الهيدرولوكي للري بالتنقيط صنف البيلي. استخدم نوعين من مياه الري مياه ممغنطة ومياه عادية. الوحدة في كل نوع من مياه الري ضمت اربع نباتات والمعاملتين تم تكرارها خمس مرات. اظهرت النتائج ان المياه الممغنطة ادت الي زياده في طول وسمك الساق الكاذبة للموز وكذلك الي تقليل الايام من الزراعة الي الازهار ومن الازهار الي الحصاد. كما اظهرت النتائج ان وزن السبيطة وعدد الكفوف في السبيطة كان اعلي تحت المياه الممغنطة. أدت مغنطة مياه الري الي تحسين الاداء الهيدرولوكي لنظام الري بالتنقيط مقارنة مع المياه العادية.  &nbsp

Uterine sparing approaches in management of placenta accreta: a summarized review

Placenta accreta is a potentially life-threatening obstetric condition that required multidisciplinary approach to management. Placenta accreta occurs in complete absence of the decidua basalis. Women with previous cesarean section delivery or placenta previa are known to be at greater risk of placenta accreta. A previous study reported that 24%& 67% increase in the incidence of placenta accreta in women 1 versus 3 or more previous cesarean deliveries respectively. Antenatal diagnosis of placental invasion has the potential to improve maternal and fetal outcomes. In practice, incomplete non-separation of the placenta at delivery leads to massive obstetric hemorrhage resulting in maternal morbidities such as massive blood transfusion, DIC, injury to the bladder and intestines and the need for hysterectomy. Sonographic examination with gray scale and color doppler imaging is the recommended first line modality for diagnosis of morbidly adherent placenta. Techniques developed for conservative management are techniques developed to preserve uterus and future fertility which is crucially linked to societal status and self-esteem

Detour Polynomials of Generalized Vertex Identified of Graphs

تعد مسافة الالتفاف من أهم أنواع المسافات التي لها تطبيقات حديثة في الكيمياء وشبكات الكمبيوتر، لذلك حصلنا في هذا البحث على متعددات حدود الالتفاف وأدلتها لـ  nمن البيانات المنفصلة عن بعضها البعض بالنسبة للرؤوس ، n≥3. أيضًا وجدنا متعددات حدود الالتفاف وأدلتها لبعض البيانات الخاصة والتي لها تطبيقات مهمة في الكيمياء.The Detour distance is one of the most common distance types used in chemistry and computer networks today. Therefore, in this paper, the detour polynomials and detour indices of vertices identified of n-graphs which are connected to themselves and separated from each other with respect to the vertices for n≥3 will be obtained. Also, polynomials detour and detour indices will be found for another graphs which have important applications in Chemistry.