Investigation and Statistical Analysis for Optimizing Surface Roughness, Cutting Forces, Temperature, and Productivity in Turning Grey Cast Iron

This paper investigated the influence of cutting parameters, including feed rate, cutting speed, tool nose radius, and wet or dry cutting conditions, on the resultant force, cutting edge/workpiece temperature, and surface roughness when turning grey cast iron. Results showed that increasing the feed rate increased the resultant force, cutting temperature, and surface roughness. At the same time, increasing the cutting speed and nose radius increased the cutting temperature, which in turn reduced the resultant force. For practical applications, basic mathematical calculations based on the sole effect of each parameter on the output of the experiments were used to estimate the extent of percentage increase in cutting temperature due to increasing feed rate, cutting speed, and nose radius. Similarly, the same approach was used to estimate the effect of increasing feed rate, cutting speed, and nose radius on average surface roughness. Results showed that increasing the feed rate increases the cutting temperature by 5 to 11% depending on the nose radius and cutting speed. On the other hand, increasing the cutting speed was found to have limited effect on cutting temperature with small nose radius whereas this effect increases with increasing the nose radius reaching about 11%. Increasing the nose radius also increases the cutting temperature, depending mainly on cutting speed, reaching a maximum of 21% at higher cutting speeds. Results also showed that increasing the feed rate increased the average surface roughness considerably to about 120% at high cutting speeds and a large nose radius. On the other hand, increasing the cutting speed and nose radius reduced the surface roughness (i.e., improved surface quality) by a maximum of 29 and 23%, respectively. In order to study the combined effects of the cutting parameters on the three responses, namely, the resultant cutting force, cutting temperature, and surface roughness, full factorial design and ANOVA were used, where it was found to be in good agreement with mathematical calculations. Additionally, the desirability function optimization tool was used to minimize the measured responses whilst maximizing the material removal rate

GIS-based rockfall hazard zones modeling along the coastal Gulf of Aqaba Region, Egypt

Rockfall is a natural hazard in mountainous areas not to be underestimated. Mass activities differing in rock volume may cause considerable economic damage. Accomplishing qualitative appraisal of high-potential zones for rockfall is a first step towards implementing mitigation strategies. Nowadays, Geographical Information Systems (GIS) are the state-of-the-art tool for a fast and economic approach of identifying potential hazard zones rather than using conventional mapping with in-situ field data. Primarily, current research focuses on designing and implementing user-friendly tools delineating potential rockfall hazard zonation (RHZ). The constructed model examines triggering factors like slope, aspect, elevation, lithology, structural lineament, rainfall intensity, and seismic activity focal depth of a mountainous coastal region (Gulf of Aqaba, Egypt). The extracted geomorphological parameters were based on a high-resolution TanDEM-X Digital Elevation Model. The enhanced Landsat ETM + 7 was used to generate the lithological and structural lineament parameters, while the rainfall data were collected from NASA project tool. The zonation model was implemented by means of ESRI’s ArcGIS Pro ModelBuilder. Google Earth Pro orthophotos compared with the generated rockfall hazard zonation map indicate the potential RHZ with high reliability. The achieved results show that 15 % of the study area qualifies as a high rockfall hazard zone. As the RHZs generated by the model depend on the input data and the selected rating scores and weights, obtaining ground truth is essential to get a trustworthy result. Finally, this study recommends employing the built RHZ model on similar terrains worldwide to support decision-makers involving any sustainable development projects

Geo-hazards assessment of the new-found industrial communities: an example from the 10th of Ramadan Industrial Region, Egypt

Abstract The impacts of Geo-hazard events are main obstacles to the use of land in numerous arid and semi-arid provinces of the World. Furthermore, the various activities of industrial communities, such as Egypt's 10th Ramadan Industrial Region (10th RIR), are the most dangerous examples of waste's impact on soil, surface water, and groundwater. The current study uses image processing and GIS tools to identify, delineate, monitor, and assess some of the environmental hazards caused by both human and natural activities in the 10th RIR. The findings revealed that there are rapid changes in land cover, which could be attributed to both anthropogenic and natural activities. Furthermore, the results revealed that waterlogging, salt-affected soils, water pollution, and flash floods were the most serious environmental threats to the 10th RIR. The obtained geo-hazard map showed that the 10th RIR has high flash flood hazards zones that are geospatially distributed in the southern parts of the Wadi Gafra basin and the western parts of 10th of Ramadan City. Furthermore, salinized soil zones are viewed as geospatially restricted zone in the eastern portion of 10th of Ramadan City and/or near the oxidation ponds. Additionally, vast areas of highly contaminated groundwater exist beneath industrial, urban, and oxidation pond zones. The current work provides decision-makers with numerous mitigation measures and recommendations required to minimize the impacts of geo-environmental hazards endangering the 10th RIR

Effect of dietary sage (Salvia officinalis L.) on the growth performance, feed efficacy, blood indices, non-specific immunity, and intestinal microbiota of European sea bass (Dicentrarchus labrax)

Adding medicinal herbs to aquafeed is recommended for feasible aquaculture activity. This study tested for 90 days the effect of dietary sage (Salvia officinalis L.) on the growth performance, feed efficacy, blood indices, non-specific immunity, and intestinal microbiota of European sea bass (Dicentrarchus labrax; n = 300 fish). Fish with an initial weight of 12 ± 0.1 g/fish were distributed in five treatments and fed sage at 0, 2, 4, 6, and 8 mg/kg. Dietary sage at 2 g/kg diet improved the growth, feed consumption, and growth hormone secretion in European sea bass. The blood parameters in European sea bass fed on experimental diets showed normal levels for healthy fish. Significantly higher lysozyme and phagocytic activities were recorded with sage supplement at the 4 g/kg diet compared to other groups. Regarding overall bacterial count, fish given a sage-free diet (the control) showed more significant microbiota numbers, Vibrio, Escherichia coli, and acid-fermentative bacteria. Remarkably, fish fed on diets fortified with sage displayed lower records of the total bacterial count, Vibrio, and Escherichia coli than the control. Moreover, fish fed a diet enriched with high levels of sage (6 or 8 g/kg) showed increased acid-fermentative bacteria. The regression analysis showed that the optimum quantity of sage at 3.6 – 4.1 g/kg diet is recommended based on the weight gain, specific growth rate (SGR), phagocytic activity, feed conversion ratio (FCR), and lysozyme activity. In conclusion, the dietary incorporation of sage (2 – 4 g/ kg diet) enhanced growth, feed efficacy, blood indices, non-specific immune responses, and sustained healthier gut flora in European sea bass

Nephroprotective effects of Acacia senegal against aflatoxicosis via targeting inflammatory and apoptotic signaling pathways

Aflatoxin B1 (AFB1) is a common environmental pollutant that poses a major hazard to both humans and animals. Acacia senegal (Gum) is well-known for having antioxidant and anti-inflammatory bioactive compounds. Our study aimed to scout the nephroprotective effects of Acacia gum (Gum) against AFB1-induced renal damage. Four groups of rats were designed: Control, Gum (7.5 mg/kg), AFB1 (200 µg/kg b.w) and AFB1-Gum, rats were co-treated with both Gum and AFB1. Gas chromatography-mass spectrometry (GC/MS) analysis was done to determine the phytochemical constituents in Gum. AFB1 triggered profound alterations in kidney function parameters (urea, creatinine, uric acid, and alkaline phosphatase) and renal histological architecture. Additionally, AFB1 exposure evoked up-regulation of mRNA expression levels of inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor α (TNFα), inducible nitric oxide synthase (iNOS), and nuclear factor kB p65 (NF-κB/P65) in renal tissue. The oxidative distress and apoptotic cascade are also instigated by AFB1 intoxication as depicted in down-regulated protein expression of the nuclear factor erythroid 2–related factor 2 (Nrf2) and superoxide dismutase type 1 (SOD1) along with upregulation of cytochrome c (Cyto c), and cleaved Caspase3 (Casp3–17 and 19) in renal tissue. In conclusion, current study obviously confirms the alleviating effects of Gum supplementation against AFB1-induced renal dysfunction, oxidative harm, inflammation, and cell death. These mitigating effects are suggested to be attributed to Gum's antioxidant and anti-inflammatory activities. Our results recommend Gum supplementation as add-on agents to food that might aid in protection from AFB1-induced nephrotoxicity

National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer

Colorectal cancer (CRC) represents a major public health problem as the second leading cause of cancer-related mortality in the United States. Of an estimated 140,000 newly diagnosed CRC cases in 2018, roughly one-third of these patients will have a primary tumor located in the distal large bowel or rectum. The current standard-of-care approach includes curative-intent surgery, often after preoperative (neoadjuvant) radiotherapy (RT), to increase rates of tumor down-staging, clinical and pathologic response, as well as improving surgical resection quality. However, despite advancements in surgical techniques, as well as sharpened precision of dosimetry offered by contemporary RT delivery platforms, the oncology community continues to face challenges related to disease relapse. Ongoing investigations are aimed at testing novel radiosensitizing agents and treatments that might exploit the systemic antitumor effects of RT using immunotherapies. If successful, these treatments may usher in a new curative paradigm for rectal cancers, such that surgical interventions may be avoided. Importantly, this disease offers an opportunity to correlate matched paired biopsies, radiographic response, and molecular mechanisms of treatment sensitivity and resistance with clinical outcomes. Herein, the authors highlight the available evidence from preclinical models and early-phase studies, with an emphasis on promising developmental therapeutics undergoing prospective validation in larger scale clinical trials. This review by the National Cancer Institute's Radiation Research Program Colorectal Cancer Working Group provides an updated, comprehensive examination of the continuously evolving state of the science regarding radiosensitizer drug development in the curative treatment of CRC