1,384 research outputs found

    Possibility of Searching for Fourth Generation Neutrino at Future ep Colliders

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    We investigate the production of fourth generation neutrino in the context of new eν4We \nu_4 W magnetic dipole moment type interaction in epep collisions at the future lepton-hadron colliders. We have obtained the mass limits of 700 GeV for THERA (S\sqrt S=1 TeV) and 2.8 TeV for LC⊗\otimes LHC (S\sqrt S=3.74 TeV).Comment: 7 pages, 6 figures, typos adde

    Development of Rainfall Intensity-Duration-Frequency (IDF) Curve for Abuja, Nigeria

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    Urban flooding is a major social and economic problem of any nation. The social implication is attributed to loss of lives and property, unwanted displacement and emotional disturbance attached. While that of economic problem is the cost of mitigation of flood and the aftermath solution. Thus, storm water drainage is part of essential modern city infrastructure. The need for proper analysis and design of drainages and other road water facilities cannot be overemphasized. To achieve this, critical analysis of available rainfall data, which is a key input, is required. A 35 years daily rainfall data were obtained from NIMET, from which the analysis was carried out using frequency method. The output generated are presented in graphical forms and model. Ultimately, an IDF curve generated, depicts Abuja rainfall pattern from which a 3-parameter model equation, I = 37Tr0.2 (t + 0.1)−0.9 was formulated. This is site or location specific. The curve and/or the formulated model can be adopted to determine rainfall intensity of Abuja city if the rainfall duration and return period are predictable

    Evaluation of Loop-Mediated Isothermal Amplification (LAMP) for Diagnosis of Theileria annulata in both Cattle and Buffaloes in Upper Egypt

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    Loop-Mediated Isothermal Amplification (LAMP) assay was used for detection of Theileria annulata infection in field samples from both cattle and buffaloes. These samples were collected from three governorates in Upper Egypt that include Assiut, EL-Fayoum and EL-wady EL-Gaded governorates. Reverse Line Blot (RLB) assay was used as a reference test for evaluation of LAMP assay efficacy in the diagnosis of bovine theileriosis. The obtained results revealed that according to the results of LAMP assay the infection rates were 65.24% and 43.24% in cattle and buffaloes, respectively. The evaluation study of LAMP test revealed high sensitivity in cattle (78.10%) if compared with buffaloes (47.37%). Specificity was higher in buffaloes (61.11%) if compared with cattle (57.53%). This study concluded that the LAMP assay was sensitive and specific assay in diagnosis of Theileria annulata infection. So, it is recommended to use LAMP assay, especially during molecular epidemiological surveys, which should be applied on a wide range because it will give a clear picture about the epidemiology of the disease, which helps in its prevention and control

    Benign prostatic hyperplasia in a 23 year old man with progeroid syndrome

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    Introduction: Progeroid syndromes are characterized by accelerated aging and early development of diseases typically associated with aging. Premature development of tumors including BPH, maybe observed in these patients, which can lead to significant bladder outlet obstruction.Observation: The index patient was a 23 year old man who presented to us with lower urinary tract symptoms (LUTS), features of obstructive nephropathy and was noticed to have been aging rapidly. He had features of premature aging, bilateral cataract and enlarged benign prostate (BPH). He eventually succumbed to obstructive nephropathy and urosepsis.Conclusion: Progeroid syndromes may be associated with premature development of obstructive BPH

    Antibiotic susceptibility profile of uropathogens isolated from pregnant women in selected hospitals in Ilorin

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    Background: Urinary tract infection (UTI) is one of the most common infections among pregnant women and if untreated could lead to serious complications.Objective: This work was carried out to determine the prevalence rate of Enterobacteriaceae uropathogens and their antibiotics susceptibility profile among pregnant women attending two ante-natal clinics in Ilorin, Nigeria.Materials and Methods: A total of 111 pregnant women between the ages of 18-50 attending ante-natal clinic at University of Ilorin Teaching Hospital and Civil Service Hospital, Ilorin participated in the study. Mid-stream urine samples were collected and cultured on Cysteine-Lactose-Electrolyte Deficient agar. Presence of significant bacteriuria (> 105 cfu/mL) was determined using the plate count method. Antibiotic susceptibility testing was done using Kirby-Bauer disk diffusion technique.Results: Of the 111 urine samples collected, 27.9% of them were found positive on culture. Among the isolated organisms, Klebsiella oxytoca (25.7%) followed by Klebsiella pneumonia (22.9%), were the most prevalent. Isolated bacteria were resistant to at least one antibiotic with the highest resistance seen with amoxicillin (94.3%), streptomycin (77.1%) and nitrofurantoin (54. 3%). Amoxicillin-clavulanic acid (51.4%), ceftriaxone (51.4%), ceftazidime (34.3%), cotrimoxazole (51.4%), imipenem (2.9%), ciprofloxacin (14.3%) and gentamicin (25.7%) have the lowest rate of bacteria resistance. Of the isolates, 82.9% showed Multi-Antibiotic Resistance Index (MARI) ≥ 0.3.Conclusion: High prevalence of bacteriuria in both symptomatic and asymptomatic pregnant women was observed in the study areas. The alarming rate of multi-antibiotic resistance strain is therefore an indicator of a serious clinical problem in the community.Keywords: Bacteriuria, pregnancy, urine culture, antibiotic susceptibilit

    Prospects and constraints on utilization of Jatropha curcas seeds in animal feedstuff

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    Combined physical, chemical and biochemical methods were used to process virgin seed meal of Jatropha curcas L. into treated Jatropha Seed Meal (JSM). Graded levels (0, 5, 10, 15, 20 and 25%) JSM treated by the various methods was included in the test diets which were fed ad libitum to 360 albino rats for a month in a single factor design trial. The results revealed that feed intake was numerically highest (p > 0.05) for the rats on the 5 % treated JSM diet, while feed efficiency was highest (p > 0.05) for those on the 10 % treated JSM diets. Weight gain was significantly highest (p< 0.05) for the rats on 10 and 15 % treated JSM diets. Lowest survival rate (17%) was observed on treated JSM diet processed by boiling, roasting followed by fermenting. Biochemical indices measured on treated JSM based diets were comparable with those obtained on the conventional diet (p > 0.05) except for blood cholesterol level (p < 0.05) which was elevated with increasing treated JSM in diets. There were also no significant differences recorded on AST and ALP activities (p > 0.05) between the treatments. Haematological indices investigated including PCV, RBC, Hb were insignificantly influenced by the 5% dietary treated JSM compared with the control diet (p > 0.05) and there was non-significant effect of the dietary treatment on the WBC differential counts of lymphocytes, eosinophils, monocytes and neutrophils. It was established in this study that inclusion of 5% treated JSM in diets had no detrimental effect on albino rats. Further researches are in progress to investigate inclusion of the treated JSM in diets at levels higher than the 5% used in this study.Keywords: JSM, Cockerels, Performance, Biochemical and haematological parameter

    Thymoquinone and curcumin modify inducible nitric oxide synthase, caspase 3, and thioredoxin immunohistochemical expression in acetaminophen hepatotoxicity

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    Background: Acetaminophen (APAP) hepatotoxicity is characterised by an extensive oxidative stress due to depletion of glutathione (GSH), which results in massive lipid peroxidation and subsequent liver injury. The current paradigm suggests that mitochondria are the main source of reactive oxygen species (ROS), which impair mitochondrial function and are responsible for cell signalling resulting in cell death. This study was designed to compare the potential impact of thymoquinone (THQ), and/or curcumin (CURC) on liver injury induced by APAP toxicity in rats. Materials and methods: Serum levels of alanine transaminase, aspartate transaminase, total bilirubin, and total protein were measured. In addition, liver nitric oxide (NO), malondialdehyde, reduced glutathione (GSH), and superoxide dismutase (SOD) were estimated. Moreover, these biochemical parameters were confirmed by histopathological and immunohistochemical investigations for the expression of thioredoxin, iNOS and caspase 3. Results: Acetaminophen toxicity elevated most of the above-mentioned parameters but decreased GSH, SOD, and total protein levels. Histologically, liver sections demonstrated liver injury characterised by hepatocellular necrosis with nuclear pyknosis, karyorrhexis and karyolysis. Immunohistochemical study revealed increased expression of iNOS and caspase 3 proteins, while the thioredoxin protein expression was decreased. Conclusions: Treatment with the THQ and CURC regulated the biochemical and histopathological alterations induced by APAP toxicity. It was concluded that the combination strategy of THQ and CURC might be considered as a potential antidote in combating liver injury induced by APAP with minimal side effects
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