Cancer and Its Treatment in Main Ancient Books of Islamic Iranian Traditional Medicine (7th to 14th Century AD)

ABSTRACT: Islamic medicine is regarded as a comprehensive medical school with a long, glorious and worldwide reputation. Some of the physicians of this school are famous worldwide and have contributed valuable services to the scientific world. Given the dramatically increasing prevalence of cancer and the relative inefficacy of current medications, there is a great demand for the introduction of effective therapeutic approaches. To this end, integration of traditional medicine with modern medical treatments represents a promising option. In this essay, methods of diagnosis and treatment of cancer have been mentioned from the viewpoint of five famous physicians before the Mongolian attack who used Islamic medicine, namely Rhazes, Akhaveyni, Ahwazi, Avicenna and Jorjani. The ideas discussed dates back to a period between the eighth and fourteenth centuries

The malleable brain: plasticity of neural circuits and behavior: A review from students to students

One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic connections, referred to as long-term potentiation (LTP) and long-term depression (LTD) respectively. Such phenomena have been described in a variety of model organisms, which are used to study molecular, structural, and functional aspects of synaptic plasticity. This review originated from the first International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Alpbach, Austria (Sep 2016), and will use its curriculum and discussions as a framework to review some of the current knowledge in the field of synaptic plasticity. First, we describe the role of plasticity during development and the persistent changes of neural circuitry occurring when sensory input is altered during critical developmental stages. We then outline the signaling cascades resulting in the synthesis of new plasticity-related proteins, which ultimately enable sustained changes in synaptic strength. Going beyond the traditional understanding of synaptic plasticity conceptualized by LTP and LTD, we discuss system-wide modifications and recently unveiled homeostatic mechanisms, such as synaptic scaling. Finally, we describe the neural circuits and synaptic plasticity mechanisms driving associative memory and motor learning. Evidence summarized in this review provides a current view of synaptic plasticity in its various forms, offers new insights into the underlying mechanisms and behavioral relevance, and provides directions for future research in the field of synaptic plasticity.Fil: Schaefer, Natascha. University of Wuerzburg; AlemaniaFil: Rotermund, Carola. University of Tuebingen; AlemaniaFil: Blumrich, Eva Maria. Universitat Bremen; AlemaniaFil: Lourenco, Mychael V.. Universidade Federal do Rio de Janeiro; BrasilFil: Joshi, Pooja. Robert Debre Hospital; FranciaFil: Hegemann, Regina U.. University of Otago; Nueva ZelandaFil: Jamwal, Sumit. ISF College of Pharmacy; IndiaFil: Ali, Nilufar. Augusta University; Estados UnidosFil: García Romero, Ezra Michelet. Universidad Veracruzana; MéxicoFil: Sharma, Sorabh. Birla Institute of Technology and Science; IndiaFil: Ghosh, Shampa. Indian Council of Medical Research; IndiaFil: Sinha, Jitendra K.. Indian Council of Medical Research; IndiaFil: Loke, Hannah. Hudson Institute of Medical Research; AustraliaFil: Jain, Vishal. Defence Institute of Physiology and Allied Sciences; IndiaFil: Lepeta, Katarzyna. Polish Academy of Sciences; ArgentinaFil: Salamian, Ahmad. Polish Academy of Sciences; ArgentinaFil: Sharma, Mahima. Polish Academy of Sciences; ArgentinaFil: Golpich, Mojtaba. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Nawrotek, Katarzyna. University Of Lodz; ArgentinaFil: Paid, Ramesh K.. Indian Institute of Chemical Biology; IndiaFil: Shahidzadeh, Sheila M.. Syracuse University; Estados UnidosFil: Piermartiri, Tetsade. Universidade Federal de Santa Catarina; BrasilFil: Amini, Elham. University Kebangsaan Malaysia Medical Centre; MalasiaFil: Pastor, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Wilson, Yvette. University of Melbourne; AustraliaFil: Adeniyi, Philip A.. Afe Babalola University; NigeriaFil: Datusalia, Ashok K.. National Brain Research Centre; IndiaFil: Vafadari, Benham. Polish Academy of Sciences; ArgentinaFil: Saini, Vedangana. University of Nebraska; Estados UnidosFil: Suárez Pozos, Edna. Instituto Politécnico Nacional; MéxicoFil: Kushwah, Neetu. Defence Institute of Physiology and Allied Sciences; IndiaFil: Fontanet, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; ArgentinaFil: Turner, Anthony J.. University of Leeds; Reino Unid

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Energy Consumption Modeling of Manufacturing Processes in Industrial Units Based on Linear Piece-Wise Approximation Method with the aim of Implementing Demand Response Programs and Participating in Energy and Ancillary Service Market

In this paper, a detailed modeling of energy consumption in the processes of producing aluminum and cement industrial units based on the linear piece-wise approximation (LPWA) method is presented. The presented model has been implemented in the day-ahead energy management planning of a microgrid including these industrial units. In order to increase the profit of the mentioned industrial units, the demand response programs are implemented and therefore these units are able to participate in the energy and ancillary services market. The energy management planning proposed in this paper, considers the exact model and all constraints of the industrial units and microgrid in order to maximize the profit of the microgrid and these units. The performance of the model and the proposed planning has been evaluated through two case studies, with and without implementation of demand response programs. In addition, the effect of the changes in the profit obtained by selling the product of each industrial unit and the prices of sold energy by microgrid to the electricity market, on the profit of the units and the microgrid, have been examined using the sensitivity analysis. The obtained results, besides validating the proposed model, show that the implementation of demand response programs and the participation of industrial units in the energy and ancillary services market, not only modifying the demand curve but also increase the profit of the microgrid and units

Factors affecting trust in publishing personal information in online social network: An empirical study of Malaysia’s Klang Valley users

Online Social Networking (OSN) is a platform that enables one to socialize over the world online without having to meet anyone physically or face to face. However, privacy in OSN sites is becoming a main concern for users because of the potential threats that come with sharing one’s personal information online. The purpose of our study was to examine the key factors that influence the trust in publishing personal information on Online Social Network (OSN) sites in Malaysia. Primary data were gathered from 201 users comprising university students and working adults residing in the Klang Valley. Five factors were selected to gauge the users’ perception of potential threats , namely, security/privacy of the website, word of mouth of family and friends, functional motives of OSN users, social motives of OSN users and psychological motives of OSN users. Results of the study showed that security/privacy, word of mouth, functional motives and social motives significantly affected the publishing of respondents’ personal information on online social network sites. The implication is that the largest challenge of both now and in the future, in terms of users protecting themselves and their information, will be to find out and understand how to effectively access and change the privacy settings offered by all OSN sites

Social Equity Considerations in the Implementation of Caribbean Climate Change Adaptation Policies

As the Small Island Developing States of the Caribbean prepare to take climate change adaptation measures, there is a distinct possibility that the most vulnerable groups, especially the poor, women, indigenous, elderly, and children in rural and coastal communities are at risk of being marginalized. It is necessary to take into consideration the adaptation needs of these groups that are likely to be disproportionately affected due to inherent structural and social disparities. In this paper we focus on the need to ensure inclusion and social equity in adaptation planning as climate change issues disproportionately impact health, settlement, and livelihoods of these vulnerable groups. We also focus on climate change potential impacts on tourism, agriculture and fisheries sectors, which are the major economic drivers of these island states. Based on Caribbean region wide observations, we recommend priority areas including increasing community participation, local initiatives and filling critical socio-economic and livelihood data gaps, which policy makers need to focus on and incorporate in their climate change adaptation plans in order to ensure effective and equitable climate change adaptatio

Designing mobile games for improving self-esteem in children with ADHD

There is a growing number of children with Attention Deficit Hyperactivity Disorder (ADHD). Research has shown that these children process information quite differently from others. A lot of ADHD diagnosed children (especially Inattentive type ADHD) are more of a visual learner, easily distracted, struggle to follow instructions, are easily forgetful and more importantly have low self-esteem. Parents are often overwhelmed by the amount of information they receive on how to handle their child's symptoms and learning style. In this project, we propose a novel way to increase the self-esteem of ADHD diagnosed children through use of computer games. We came up with a set of design principles that can be applied to any game to make it suitable for ADHD children, especially with the aim of increasing their self-esteem. Our game design was applied to an existing open source mobile game (GLtron). The results of a pilot study showed that users enjoyed playing the game and found it valuable for increasing players’ self-esteem

Impact of foreign direct investment on income inequality: Evidence from selected Asian economies.

The United Nations lists 17 Sustainable Development Goals for Agenda 2030, one of which is SDG-10, which focuses on eradicating inequality and addressing critical regional and global challenges. The fight against income inequality is heavily dependent on foreign direct investment all over the world. In this connection, the present study aimed to investigate the individual and interactive impact of foreign direct investment, human capital, and economic growth on income inequality by employing the interactive model. Based on the panel data set covering ten counties spanning each region of Asia from 1990 to 2020. In light of the slope homogeneity, cross-sectional dependency tests, and Westerlund co-integration test, we discover that all of the variables are cointegrated over the long run. A cross-sectional IPS (CIPS) unit root test is employed to check stationarity. Additionally, the study used the Augmented Mean Group (AMG) approach to produce accurate results in estimation. The results confirm that FDI affects inequality negatively. However, the impact of FDI is more effective in the presence of human capital. It means that human capital deepens the effect of FDI on inequality; the country will be more effective in reducing inequality by having a higher level of human capital and consider it a more powerful tool to bring equality. To reduce inequality, it is suggested that a policy mix of FDI and HC could be made