MultiCellDS : a community-developed standard for curating microenvironment-dependent multicellular data

Exchanging and understanding scientific data and their context represents a significant barrier to advancing research, especially with respect to information siloing. Maintaining information provenance and providing data curation and quality control help overcome common concerns and barriers to the effective sharing of scientific data. To address these problems in and the unique challenges of multicellular systems, we assembled a panel composed of investigators from several disciplines to create the MultiCellular Data Standard (MultiCellDS) with a use-case driven development process. The standard includes (1) digital cell lines, which are analogous to traditional biological cell lines, to record metadata, cellular microenvironment, and cellular phenotype variables of a biological cell line, (2) digital snapshots to consistently record simulation, experimental, and clinical data for multicellular systems, and (3) collections that can logically group digital cell lines and snapshots. We have created a MultiCellular DataBase (MultiCellDB) to store digital snapshots and the 200+ digital cell lines we have generated. MultiCellDS, by having a fixed standard, enables discoverability, extensibility, maintainability, searchability, and sustainability of data, creating biological applicability and clinical utility that permits us to identify upcoming challenges to uplift biology and strategies and therapies for improving human health

MultiCellDS: a standard and a community for sharing multicellular data

Cell biology is increasingly focused on cellular heterogeneity and multicellular systems. To make the fullest use of experimental, clinical, and computational efforts, we need standardized data formats, community-curated "public data libraries", and tools to combine and analyze shared data. To address these needs, our multidisciplinary community created MultiCellDS (MultiCellular Data Standard): an extensible standard, a library of digital cell lines and tissue snapshots, and support software. With the help of experimentalists, clinicians, modelers, and data and library scientists, we can grow this seed into a community-owned ecosystem of shared data and tools, to the benefit of basic science, engineering, and human health

PERBANDINGAN BATA CANDI KAYEN DAN PENGRAJIN BATA DESA SUKOLILO KECAMATAN SUKOLILO KABUPATEN PATI BERDASARKAN ANALISIS PETROGRAFI

Topic: Kayen Temple is the one of temple which is built from bricks. It is located in Pati. This brick has length 32-39 cm, wide 23-24 cm, and thick 6-8 cm. This size similar to the size of the brick used in temples in Magelang. Recently, Kayen Temple just remains the foot of temple. Problems and Objectives: The problems in this study were (1) How do the characteristics of Kayen Temple brick and bricks used by craftsmen in Sukolilo village? (2) What is the context between Kayen Temple and craftsmen in Sukolilo village, Sukolilo, Pati? The objectives of this study were (1) To know the characteristics of the Kayen Temple bricks as suggestion for the selection of temple reconstruction material in the future, (2) To know the context between Kayen Temple bricks and bricks by craftsmen in the Sukolilo village, Sukolilo, Pati. Methods: Method used in this study was a qualitative method with experimental inductive reasoning. The analysis used was petrographic analysis on each brick sample. Conclusion: The quality of Kayen Temple bricks was better than the bricks from craftsmen in Sukolilo village. Kayen Temple bricks was produced locally. Raw material in the Kayen Temple is gotten from Mount Muria area. Bricks had been produced by craftsmen in Sukolilo can be used as raw material for the reconstruction process at Kayen Temple with certain modification

MANIK-MANIK SITUS PERENGAN DAN KOPEN KECAMATAN TAWANGSARI, KABUPATEN SUKOHARJO JAWA TENGAH

Topik: Situs Perengan dan Kopen terletak di Kecamatan Tawangsari Kabupaten Sukoharjo, Provinsi Jawa Tengah. Dari lokasi tersebut diperoleh manik-manik berjumlah 769 butiran utuh dan 4 fragmen. Temuan manik-manik didapatkan dari masyarakat dan temuan permukaan. Manik-manik yang ditemukan sebagian besar merupakan manik-manik Indo- Pacific. Selain itu ditemukan juga temuan artefak logam, gerabah, dan artefak batu. Permasalahan dan Tujuan: 1. Bagaimana tipologi manik-manik yang ditemukan di Situs Perengan dan Situs Kopen Kecamatan Tawangsari Kabupaten Sukoharjo Provinsi Jawa Tengah berdasarkan bahan, bentuk, dan warna? 2. Apa latarbelakang keberadaan manik-manik di Situs Perengan dan Situs Kopen? Penelitian ini bertujuan untuk mengetahui tipologi manik-manik yang ditemukan di Situs Perengan dan Kopen untuk dibandingkan dengan situs-situs lain dengan tipe temuan yang sejenis. Selain itu penelitian dilakukan untuk mengetahui latarbelakang situs Perengan dan Kopen berdasarkan temuan manik-manik dan temuan penyerta. Metode: Penelitian ini bersifat eksploratif dengan metode penalaran induktif. Menggunakan analisis tipologis dan komparatif. Manik-manik diklasifikasikan berdasarkan bahan, bentuk, ukuran dan warna. Selanjutnya diperbandingkan dengan situs lain yang memiliki temuan sejenis terutama di Gunungkidul, sehingga dapat diperkirakan jalur persebaran manik-manik Indo- Pacific di Asia Tenggara. Kesimpulan : Dari material batu, manik-manik Situs Perengan dan Kopen terbagi menjadi enam tipe, sedangkan dari material kaca dibagi menjadi sepuluh tipe. Latarbelakang Situs Perengan diduga merupakan Situs Kubur, sedangkan Situs Kopen diindikasikan sebagai situs permukiman. Kesimpulan tersebut diperkuat dengan temuan-temuan penyerta dan dibandingkan juga dengan situs-situs yang memiliki jenis temuan yang sama terutama di Gunungkidul

Kontekstualisasi Situs-Situs Megalitik di Pegunungan Muria Jawa Tengah, Dalam Sistem Kepercayaan Kejawen (Kajian Etnoarkeologi)

Topic The finding of megalithic tradition sites on Muria Mountains is apparently interesting to examine, since people still using those sites for Kejawen ritual. Though the sites were found scattered into a few location, it is still connected to each other. There is a modification to the sites in shape and influence from another beliefs as Hindu-Budha and Islam, but still with an obvious concept of ancient cult. Then the question that appear is about the context of those megalithic sites present days. Problems and Objectives The question of this research is �How the contextualization of megalithic sites of Muria Mountains in the Kejawen belief system?� The objective of this research is to know the context of megalithic sites on present days, especially in the Kejawen belief system. To complete the objective, the writer need to assemble the data about religion development in the south side of Muria Mountains area. Methods Inductive approach was used in this research, with deep descriptive which is giving the archaeological data through the etnographical work system. Then artefactual analysis is done with artefact and environment as the variable, also analysis of symbol with the stage of the exegesical meaning, operational and positional approach. The result of analysis was synthesised and the conclusion appear so the quaestion of the research can be answered. Conclusion The megalithic tadition sites that had been found were related to the cult ritual. The utilizing of site that continues has made the modification and interference of belief that developed in Indonesia. Syncretism between megalithic tradition, Hindu- Budha and Islam has showed up a site context in Javanese traditional belief or it called Kejawen that can be seen on the sites in Muria Mountains

STRATEGI PELESTARIAN SITUS KAPAL TENGGELAM INDONOR DI KEPULAUAN KARIMUNJAWA

This study raised the issue of conservation Topic: strategies to maintain the integrity of the vessel and its values. Problem/Issue: 1. What is the appropriate strategy for the field condition of Indonor conservation site? Purpose of the Study: The purpose of this study is to find an appropriate conservation strategy for the field condition. The adjustment is based on the ship condition, the environment, the stakeholders, and the activity around the site. Method: The methods of this study are descriptive and narrative which use inductive reasoning. Data collection technique that been used is qualitative data. The collected data will be analyzed using an analysis tool, namely the ship physical analysis of the destroyer factors, zoning analysis, legislation-based analysis, and the institutional analysis. The result of the analysis will be synthesized to obtain the ship conservation strategy of Indonor Site. Conclusion: This study has found a data about the ship physical condition and its surroundings as well as the stakeholders� opinions and views about the conservation. The data were collected through a literature review, an underwater diving survey, and interviews with stakeholders. Based on qualitative analysis, this study resulted a recommendation as an Indonor site conservation plan which includes three main programs, namely: protection programs, development programs, and utilization programs that are run collaboratively among the stakeholders