Coded Caching based on Combinatorial Designs

We consider the standard broadcast setup with a single server broadcasting information to a number of clients, each of which contains local storage (called \textit{cache}) of some size, which can store some parts of the available files at the server. The centralized coded caching framework, consists of a caching phase and a delivery phase, both of which are carefully designed in order to use the cache and the channel together optimally. In prior literature, various combinatorial structures have been used to construct coded caching schemes. In this work, we propose a binary matrix model to construct the coded caching scheme. The ones in such a \textit{caching matrix} indicate uncached subfiles at the users. Identity submatrices of the caching matrix represent transmissions in the delivery phase. Using this model, we then propose several novel constructions for coded caching based on the various types of combinatorial designs. While most of the schemes constructed in this work (based on existing designs) have a high cache requirement (uncached fraction being $\Theta(\frac{1}{\sqrt{K}})$ or $\Theta(\frac{1}{K})$, $K$ being the number of users), they provide a rate that is either constant or decreasing ($O(\frac{1}{K})$) with increasing $K$, and moreover require competitively small levels of subpacketization (being $O(K^i), 1\leq i\leq 3$), which is an extremely important parameter in practical applications of coded caching. We mark this work as another attempt to exploit the well-developed theory of combinatorial designs for the problem of constructing caching schemes, utilizing the binary caching model we develop.Comment: 10 pages, Appeared in Proceedings of IEEE ISIT 201

Effect of antenatal corticosteroids on neonatal outcome in term elective caesarean section: a randomised controlled trial

Background: Infants born at term by elective caesarean section are more likely to develop respiratory morbidity than infants born vaginally. Prophylactic corticosteroids in singleton preterm pregnancies accelerate lung maturation and reduce the incidence of respiratory complications. Thus, the aim of this randomized controlled trial was to assess the effect of antenatal corticosteroids on neonatal outcome among term pregnant women undergoing elective caesarean section.Methods: It was an open labelled randomized controlled trial conducted among women with term pregnancy of 37-38+6 weeks and planned for caesarean section at term and who were willing to participate in the study. We randomized 50 pregnant women into intervention group which received antenatal corticosteroids in the form of injection dexamethasone 12 mg IM, 4 doses at 12 hourly intervals before term elective caesarean section and 50 pregnant women into control group which did not receive antenatal corticosteroid. Fetal outcomes were compared in both groups after caesarean section. Data were analysed using SPSS vs.20.Results: Nearly half (54%) of pregnant women belonged age group of 21-25 years and majority (58%) of pregnant women belonged to 38-39 weeks of gestation. Out of 50 pregnant women in intervention group, only two percent neonates developed RDS, four percent neonates developed transient tachypnea of neonate (TTN) and six percent neonates required NICU admission which was lower than control group. However, difference between fetal outcomes in intervention and control group was not statistically significant (p>0.05).Conclusions: Administration of prophylactic antenatal corticosteroids before 48 hours of elective term caesarean section does not have impact on fetal outcome in our study

Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes.

The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized INA-labelled protein 1 (PhIL1) have been shown to associate with glideosome machinery. Here we describe a novel PhIL1 associated protein complex that co-exists with the glideosome motor complex in the inner membrane complex of the merozoite. Using an experimental genetics approach, we characterized the role(s) of three proteins associated with PhIL1: a glideosome associated protein- PfGAPM2, an IMC structural protein- PfALV5, and an uncharacterized protein-referred here as PfPhIP (PhIL1 Interacting Protein). Parasites lacking PfPhIP or PfGAPM2 were unable to invade host RBCs. Additionally, the downregulation of PfPhIP resulted in significant defects in merozoite segmentation. Furthermore, the PfPhIP and PfGAPM2 depleted parasites showed abrogation of reorientation/gliding. However, initial attachment with host RBCs was not affected in these parasites. Together, the data presented here show that proteins of the PhIL1-associated complex play an important role in the orientation of P. falciparum merozoites following initial attachment, which is crucial for the formation of a tight junction and hence invasion of host erythrocytes

Early life exposures and the risk of inflammatory bowel disease: Systematic review and meta-analyses

Background: Early life exposures impact immune system development and therefore the risk of immune-mediated diseases, including inflammatory bowel disease (IBD). We systematically reviewed the impact of pre-, peri‑, and postnatal exposures up to the age of five years on subsequent IBD diagnosis. Methods: We identified case-control and cohort studies reporting on the association between early life environmental factors and Crohn's disease (CD), ulcerative colitis (UC), or IBD overall. Databases were search from their inception until May 24th, 2019 until July 14th, 2020. We conducted meta-analyses for quantitative review of relevant risk factors that were comparable across studies and qualitative synthesis of the literature for a wide range of early life exposures, including maternal health and exposures during pregnancy, perinatal factors, birth month and related-factors, breastfeeding, hygiene-related factors and social factors, immigration, antibiotics, offspring health, including infections, and passive smoking. PROSPERO registration: CRD42019134980. Findings: Prenatal exposure to antibiotics (OR 1.8; 95% CI 1.2-2.5) and tobacco smoke (OR 1.5; 95% CI 1.2-1.9), and early life otitis media (OR 2.1; 95% CI 1.2-3.6) were associated with IBD. There was a trend towards an association between exposure to antibiotics in infancy and IBD (OR: 1.7, 95% CI 0.97, 2.9), supported by positive data on population-based data. Breastfeeding was protective against IBD. Other early life risk factors had no association with IBD, but data were limited and heterogenous. Interpretation: Early life is an important period of susceptibility for IBD development later in life. Tobacco smoke, infections and antibiotics were associated positively, and breastfeeding was associated negatively with IBD. Our findings offer an opportunity to develop primary prevention strategies.info:eu-repo/semantics/publishedVersio

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Social Security for Domestic Workers in India

Among all categories of the informal sector, the protection of domestic workers forms one of the biggest challenges to labour laws. The inherent subjugation involved in the work, along with the atypical nature of the work of domestic workers, makes them more vulnerable than other workers in the economy. The difficulties are associated with the work being performed within the household, primarily for non-commercial purposes. The work space, being a private space, makes regulation and implementation difficult. The lack of effective regulation and the extremely informal nature of the service render domestic workers without any basic protection. In the event of any economic uncertainty, they are left at the mercy of their employers. It is, therefore, essential to develop a system of social security that can afford adequate protection to domestic workers, with minimal state involvement in the affairs of the family. This paper seeks to provide suggestions for such a scheme, which is suited to the peculiar characteristics of domestic workers in India. It recognises that scattered and isolated schemes are insufficient to afford adequate protection to workers. The social security model suggested is a decentralised model where social security is integrated with other important concerns such as minimum wages, skill development, and increasing awareness and bargaining power of domestic workers. These suggestions have been made after undertaking an analysis of existing legal provisions for domestic workers in India and the best practices from various jurisdictions that have seen relative success in providing social security to domestic workers