Elastoplastic stress analysis of functionally graded disc under internal pressure– complas XII

The study deals with elastoplastic stress analysis of a hollow disk made of functionally graded materials (FGMs) subjected to an internal pressure. The material properties of disc are assumed to vary radially according to power law function, but Poisson’s ratio is taken constant. Small deformations and a state of plane stress are presumed, and the analysis of disk is based on Von-Mises yield criterion. The materials are assumed to be linear strain hardening, isotropic and not be affected by temperature. Variation of stresses and displacements according to gradient parameters are investigated by using analytical and finite element method. The results show that gradient parameters have an important role in determining the elastoplastic stress of functionally graded disc

Investigation of experimental research on the low velocity impact damage behavior of ncf composite plates – COMPLAS XII

In this study an experimental investigation is performed on the impact response of non-crimp fabric composite plates at room temperature. Chopped strand mat combi is used as reinforcing material and two kinds of matrix; epoxy and polyester, are also used as resin material in the composite plates. All specimens used in experiments are manufactured by vacuum assisted resin infusion method at Atard Defence and Aerospace Advanced Technology Application Research and Development Inc. An instrumented drop weight impact testing machine Instron-Dynatup 9250 HV is used for impact testing. Impact tests are performed under various impact energies ranging from initiation of damage to final perforation. Damage processes of the samples are analyzed from cross-examining load– deflection curves, energy profiling method and damaged specimens

Enthesis tissue engineering: biological requirements meet at the interface

Tendon-to-bone interface (enthesis) exhibits a complex multiscale architectural and compositional organization maintained by a heterogeneous cellular environment. Orthopedic surgeons have been facing several challenges when treating tendon pullout or tear from the bony insertion due to unsatisfactory surgical outcomes and high retear rates. The limited understanding of enthesis hinders the development of new treatment options toward enhancing regeneration. Mimicking the natural tissue structure and composition is still a major challenge to be overcome. In this review, we critically assess current tendon-to-bone interface tissue engineering strategies through the use of biological, biochemical, or biophysical cues, which must be ultimately combined into sophisticated gradient systems. Cellular strategies are described, focusing on cell sources and cocultures to emulate a physiological heterotypic niche, as well as hypoxic environments, alongside with growth factor delivery and the use of platelet-rich hemoderivatives. Biomaterial design considerations are revisited, highlighting recent progresses in tendon-to-bone scaffolds. Mechanical loading is addressed to uncover prospective engineering advances. Finally, research challenges and translational aspects are considered. In summary, we highlight the importance of deeply investigating enthesis biology toward establishing foundational expertise and integrate cues from the native niche into novel biomaterial engineering, aiming at moving today's research advances into tomorrow's regenerative therapies.Authors thank the support from the European Union Framework Programme for Research and Innovation HORIZON2020 [TEAMING Grant agreement No 739572 - The Discoveries CTR]; FCT–Fundação para a Ciência e a Tecnologia for the PhD grant of IC [PD/BD/128088/2016]; the Project NORTE-01-0145-FEDER-000021:“Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechnologies, marine-derived biomaterials and stem cells”, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and the ERC Consolidator grant of ME [ERC-2017-CoG-772817]

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

non-crimp glass fiber fabrics

This experimental study deals with the impact response of composite plates manufactured with stitch-bonded non-crimp glass fiber fabrics. Three kinds of fabrics - biaxial, triaxial, and quadraxial - are used as reinforcing material. Polyester resin is used as a matrix material in the composition of composite plates. An instrumented drop weight impact testing machine, InstronDynatup 9250 HV, is used for impact testing. Impact tests are performed under various impact energies, ranging from damage initiation to final perforation. An energy profiling method, showing the relation between impact energy and absorbed energy, was used together with load-deflection curves to determine the penetration and perforation thresholds of those composites. The failure processes of damaged specimens for different impact energies were evaluated by comparing load-deflection curves and images of damaged samples taken from the impacted and non-impacted sides. All types of composites have obvious penetration and perforation thresholds. The perforation threshold of triaxial/polyester composite is approximately 27% and 22% higher than that of the quadraxial and biaxial/polyester composites, respectively

Elastoplastic stress analysis of functionally graded disc under internal pressure– complas XII

The study deals with elastoplastic stress analysis of a hollow disk made of functionally graded materials (FGMs) subjected to an internal pressure. The material properties of disc are assumed to vary radially according to power law function, but Poisson’s ratio is taken constant. Small deformations and a state of plane stress are presumed, and the analysis of disk is based on Von-Mises yield criterion. The materials are assumed to be linear strain hardening, isotropic and not be affected by temperature. Variation of stresses and displacements according to gradient parameters are investigated by using analytical and finite element method. The results show that gradient parameters have an important role in determining the elastoplastic stress of functionally graded disc

INVESTIGATION OF EXPERIMENTAL RESEARCH ON THE LOW VELOCITY IMPACT DAMAGE

In this study an experimental investigation is performed on the impact response of non-crimp fabric composite plates at room temperature. Chopped strand mat combi is used as reinforcing material and two kinds of matrix; epoxy and polyester, are also used as resin material in the composite plates. All specimens used in experiments are manufactured by vacuum assisted resin infusion method at Atard Defence and Aerospace Advanced Technology Application Research and Development Inc. An instrumented drop weight impact testing machine Instron-Dynatup 9250 HV is used for impact testing. Impact tests are performed under various impact energies ranging from initiation of damage to final perforation. Damage processes of the samples are analyzed from cross-examining load deflection curves, energy profiling method and damaged specimens

Investigation of experimental research on the low velocity impact damage behavior of ncf composite plates – COMPLAS XII

In this study an experimental investigation is performed on the impact response of non-crimp fabric composite plates at room temperature. Chopped strand mat combi is used as reinforcing material and two kinds of matrix; epoxy and polyester, are also used as resin material in the composite plates. All specimens used in experiments are manufactured by vacuum assisted resin infusion method at Atard Defence and Aerospace Advanced Technology Application Research and Development Inc. An instrumented drop weight impact testing machine Instron-Dynatup 9250 HV is used for impact testing. Impact tests are performed under various impact energies ranging from initiation of damage to final perforation. Damage processes of the samples are analyzed from cross-examining load– deflection curves, energy profiling method and damaged specimens

A general view to political and economic events causing the collapse of Mamluk state

In this manuscript, the collapse of Mamluk State, which reigned in Egypt and Syria between the years 1250 and 1517 has been studied. Throughout our study, there found different reasons causing this collapse; the most important ones of which are political and economic. The fact that Mamluk System which had crucial role in Mamluk administration Mechanism and the problems lived along its north border are the fundamental collapsing reasons of the state. Indeed, the fights starting with Mongols and Armenians in the north of the state continued with Anatolian Turkmens and Timurids, eventually Ottomans coming from the same direction caused it to be collapsed. Mamluks were the commercial centre between east and west. At the same time, Syria owned a very industrious trade network between Anatolia. However, the geographical discoveries that Europeans carried out and the Portuguese not only military but also commercial activities in the Indian Ocean weakened Mamluks economically. In addition to this, military struggles along the north border of the state caused incompensable deficits in Mamlûk finance. Consequently, when all these negative aspects combined with an unmodernized army, Mamlûk State closed its era in 1517, when Ottoman army defeated it in Reydaniye, which was the end of a 267 year-old-state. © Sila science. all rights reserved