281 research outputs found
Circles, columns and screenings: mapping the institutional, discursive, physical and gendered spaces of film criticism in 1940s London
This article revisits the period considered within ‘The Quality Film Adventure: British Critics and the Cinema 1942-1948’, mapping the professional cultures, working contexts and industry relationships that underpinned the aesthetic judgements and collective directions which John Ellis has observed within the critics published writings. Drawing on the records of the Critics’ Circle, Dilys Powell’s papers and Kinematograph Weekly, it explores the evolution of increasingly organised professional cultures of film criticism and film publicity, arguing that the material conditions imposed by war caused tensions between them to escalate. In the context of two major challenges to critical integrity and practice – the evidence given by British producer R.J. Minney in front of the 1948 Royal Commission on the Press and an ongoing libel case between a BBC critic and MGM – the different spaces of hospitality and film promotion became highly contested sites. This article focuses on the ways in which these spaces were characterised, used, and policed. It finds that the value and purpose of press screenings were hotly disputed and observes the way the advancement of women within one sector (film criticism) but not the other (film publicity) created particular difficulties, as key female critics avoided the more compromised masculine spaces of publicity, making them harder for publicists to reach and fuelling trade resentment. More broadly, the article asserts the need to consider film critics as geographically and culturally located audiences, who experience films as ‘professional’ viewers within extended and embodied cultures of habitual professional practice and physical space
Geo-hazards of the San Vito peninsula offshore (southwestern Tyrrhenian Sea)
In this paper we present geomorphological hazard mapping of the San Vito Peninsula offshore (Sicilian margin of Tyrrhenian Sea), characterised by a very narrow continental shelf and a very dipping, tectonically active continental slope, no far from a seismogenic belt. The data set consists of morpho-bathymetric models achieved by means of multibeam survey and scattered high resolution seismic profiles. The morpho-bathymetric study highlighted some potential sites of geomorphological hazards, the most representative of which are: (i) two canyons developing from the upper slope off San Vito Cape down to the Erice basin; (ii) a dense network of small incisions across the upper slope; (iii) a very active landslide, developed onland and extending in the continental shelf close to the Scopello village. The geomorphological features that can generate submarine hazard are represented by: unstable sediment packages into canyon heads or along the upper slope; submarine canyons with regressive erosion; coastal landslides
Findable, Impactful, Citable, Usable, Sustainable (FICUS): A Heuristic for Authors of Digital Publishing Projects
We came together in Spring 2018 at a two-day think tank hosted by Duke University Libraries and supported by The Andrew W. Mellon Foundation, with dozens of other librarians, publishers, and scholarly communication stakeholders, to work on the question of sustainably publishing large digital projects. The outcome of that discussion turned into an extended project at TriangleSCI 2018 and culminated in the heuristic presented here.The heuristic can be used as a checklist to help authors (and their project team) assess their needs when it comes to making their digital projects findable, impactful, citable, usable, and sustainable (creating the acronym FICUS)
Submarine Geomorphology and Sedimentary Features around the Egadi Islands (Western Mediterranean Sea)
The physiography, the geomorphological features and the sedimentary bedforms offshore Egadi Islands (Italy) have been illustrated and mapped through an integrated analysis of high-resolution bathymetric, seismo-acoustic and sedimentological data. The study area is characterized by a wide, up to 25 km, continental shelf which is separated by a NNW trending linear incision, the Marettimo Channel, along which several erosional and depositional features have been detected and mapped. Sedimentary prograding wedges were detected at water depths between 100-125 m along the shelf margin, which accumulated during sea level fall and lowstand stages of the last glacio-eustatic cycle (post- MIS 5.5). The study detected several slope breaks defining scarps across the continental shelf, which were interpreted as coastal cliffs that originated during the post-LGM eustatic sea level rise. Several fields of different types of sedimentary bedforms, including 2-D and 3-D hydraulic dunes and sorted bedforms, were found across the continental shelf, providing evidence of a high hydrodynamic regime affecting the seafloor. Further on, the study recognized erosive and depositional features related to bottom currents (contourites) in the Marettimo Channel.
These findings provide a better understanding of the morpho-sedimentary evolution of the Egadi Islands offshore in the latest Quaternary. Moreover, they offer essential scientific support for effectively managing the most valuable priority habitats for conservation , such as Posidonia oceanica meadow and coralline algae bioconstructions (Coralligenous habitat)
Lung recurrence of papillary thyroid cancer diagnosed with antithyroglobulin antibodies after 10 years from initial treatment.
Introduction: Papillary thyroid cancer (PTC) is the most common endocrine malignancy. More than 98% of patients achieve an excellent response with no evidence of clinical, biochemical, or structural disease after initial treatment. In these patients structural recurrence is rare, more frequently diagnosed in the first 5 years from initial treatment and almost invariably localized in neck lymph nodes. Patient: We report the case of a woman affected by PTC who presented with rapidly rising anti-thyroglobulin antibodies (TgAb) level after 10 years from clinical, morphological and biochemical remission. Diagnosis and Treatment: In 2003, a 56 year old patient was treated with total thyroidectomy and radioiodine remnant ablation (RRA) for a PTC (2 cm) with minimal extrathyroidal extension (T3N1aM0 according to the 6th AJCC TNM staging system) associated with diffuse lymphocytic thyroiditis. In 2004 the patient was free of disease defined as undetectable Tg after recombinant human TSH administration in the absence of TgAb and structural disease. Since February 2012 the appearance and progressive increase of TgAb titer was observed and in 2014 a18FDG-PET scan documented three hypermetabolic lesions suggestive of lung micrometastases. The lung lesions were cytologically confirmed as PTC metastases. Both the primary tissue and the lung metastasis were positive for BRAF V600E mutation. The patient was treated with 131-radioiodine that showed radioiodine avid lung lesions that lose the ability to take up iodine at the following treatment. The patient is still alive and the lung lesions are growing slowly. Conclusions: Structural recurrence in patients that demonstrated an excellent response after initial treatment for PTC is extremely rare, and distant metastases exceptional but possible. This case is peculiar because recurrence was early identified after 10 years from initial treatment for the presence of detectable TgAb in a patient that had an histological diagnosis of lymphocytic thyroiditis but with an atypical clinical presentation (normal thyroid at neck ultrasound and undetectable TgAb and anti-thyroid peroxidase antibodies). For this reason TgAb should be tested with Tg in patients with a history of lymphocytic thyroiditis, either histological or humoral, also when TgAb is in the normal range and not suggestive of autoimmune thyroiditis
Thyroid cancers: From surgery to current and future systemic therapies through their molecular identities
Differentiated thyroid cancers (DTC) are commonly and successfully treated with total thyroidectomy plus/minus radioiodine therapy (RAI). Medullary thyroid cancer (MTC) is only treated with surgery but only intrathyroidal tumors are cured. The worst prognosis is for anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC). Whenever a local or metastatic advanced disease is present, other treatments are required, varying from local to systemic therapies. In the last decade, the efficacy of the targeted therapies and, in particular, tyrosine kinase inhibitors (TKIs) has been demonstrated. They can prolong the disease progression-free survival and represent the most important therapeutic option for the treatment of advanced and progressive thyroid cancer. Currently, lenvatinib and sorafenib are the approved drugs for the treatment of RAI-refractory DTC and PDTC while advanced MTC can be treated with either cabozantinib or vandetanib. Dabrafenib plus trametinib is the only approved treatment by FDA for BRAFV600E mutated ATC. A new generation of TKIs, specifically for single altered oncogenes, is under evaluation in phase 2 and 3 clinical trials. The aim of this review was to provide an overview of the current and future treatments of thyroid cancer with regards to the advanced and progressive cases that require systemic therapies that are becoming more and more targeted on the molecular identity of the tumor
Soil deformation analysis through fluid-dynamic modelling and DInSAR measurements: a focus on groundwater withdrawal in the Ravenna area (Italy)
This study aims at assessing the deformation processes affecting an area NW of the
city of Ravenna (northern Italy), caused by groundwater withdrawal activities. In situ
data, geologic and structural maps, piezometric measurements, underground water
withdrawal volumes, and satellite C-band SAR data were used to jointly exploit two
different techniques: 1) fluid-dynamic and geomechanical modelling (by RSE S.p.A),
and 2) Differential Synthetic Aperture Radar Interferometry (DInSAR) analysis (by
CNR - IREA). The results of the comparative analysis presented in this work brought
new evidence about the contribution of groundwater withdrawal to the total subsidence
affecting the area during the 2000-2017 time interval. In particular, they show an
increase of the subsidence from year 2000 to 2010 and a decrease from year 2010 to
2017. These results are generally in line with groundwater withdrawal data that report
a reduction of the extracted water volumes during the considered temporal interval.
Meantime, they show a delay effect in the subsidence process, partially recovered
during the 2010-2017 thanks to a stabilisation of the extracted groundwater volumes.
The presented results shade new light on the groundwater withdrawal contribution to
the subsidence of the analysed zone, although further investigations are foreseen to
better clarify the ongoing scenario
Geohazard features of the north-western Sicily and Pantelleria
We present maps of geohazard features identified across north-western Sicily and Pantelleria in the framework of the Magic project (MArine Geohazard along Italian Coasts), which involved Italian marine geological researchers in 2007-2013. These seafloor features were recognized using high-resolution bathymetry data and rely on the morphological expression of the seafloor and shallow sub-surface processes. The north-western Sicily is a complex continental margin, affected by morphodynamic, depositional, and tectonic processes. The Egadi offshore is controlled by fault escarpments and alternating retreating and progradational processes. Ustica and Pantelleria submerged edifices show the effect of volcanic activity. The Ustica seafloor is interested in volcanic, tectonic, and gravitational instability processes, while the Pantelleria offshore underwent erosive-depositional processes and the effect of bottom currents. Two levels of interpretation are represented: the physiographic domain at a scale of 1:250.000 and the morphological units and morpho-bathymetric elements at a 1:100.000 scale
Outside the gate: sub-urban legal practices in early medieval England
Many aspects of English early medieval (Anglo-Saxon) legal landscapes can be discerned in archaeological and toponymic evidence, ranging from the locations of legislative councils and judicial assemblies to sites of capital punishment. Among the corpus of such sites a striking group can be detected at the periphery of urban spaces. Gates into a number of towns appear to have functioned as legislative meeting-places, and even gave their names to some legally constituted communities, while suburban locations also feature prominently as sites of gallows and public punishment. In this paper historical, archaeological and toponymic evidence is used to examine this phenomenon of suburban legal practices and to pose questions about the wider dimensions of the early medieval legal landscape
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