14 research outputs found
A model for transcription initiation in human mitochondria.
No full textRegulation of transcription of mtDNA is thought to be crucial for maintenance of redox potential and vitality of the cell but is poorly understood at the molecular level. In this study we mapped the binding sites of the core transcription initiation factors TFAM and TFB2M on human mitochondrial RNA polymerase, and interactions of the latter with promoter DNA. This allowed us to construct a detailed structural model, which displays a remarkable level of interaction between the components of the initiation complex (IC). The architecture of the mitochondrial IC suggests mechanisms of promoter binding and recognition that are distinct from the mechanisms found in RNAPs operating in all domains of life, and illuminates strategies of transcription regulation developed at the very early stages of evolution of gene expression
Measurement of photon energy and approach angle from an analysis of the tracks of the (e+e?) pair in a multilayer ?-telescope spark chamber
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Coordination of Mitochondrial Protein Synthesis and DNA Replication Through a Novel Aminoacyl-Trna Synthetase Architecture
No full textMultiple G-quartet structures in pre-edited mRNAs suggest evolutionary driving force for RNA editing in trypanosomes
No full textMitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
No full textThe landscape of mitochondrial small non-coding RNAs in the PGCs of male mice, spermatogonia, gametes and in zygotes
No full textThe signals of selective constraints on the mitochondrial non-coding control region: insights from comparative mitogenomics of Clupeoid fishes
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