Discovering Serendipity

Dengue is the most rapidly spreading mosquito-borne viral disease in the world, with an annual incidence of over 100 million infections (Malavige, 2006). The disease is caused by four distinct, but closely related, virus strains all transmitted by the Aedes aegypti mosquito. Infection with one serotype provides life-long immunity to that virus but not to the others. Although primary prevention methods can significantly reduce the spread of disease, the incidence of dengue in Sri Lanka has unfortunately increased over the past ten years, with a total of 31 046 cases and 227 deaths being reported between January and September 2010 alone (Sri Lankan Ministry Of Healthcare and Nutrition, 2010). The demographics of dengue fever have also evolved; a decade ago, children were predominantly affected, but recent years have seen a rise in the number of adult dengue patients, with significant morbidity and mortality. The reasons for this change are still unclear (Teixeira, 2008)

Explaining the Views of Ibn Sina and Al-Ghazali on Games and Physical Exercises and their Relation to the Relationship Between Body and Soul

The purpose of this article is to describe Ibn Sina and Ghazali's philosophical views on soul and body on the one hand and to express their views on physical movements on the other hand in order to explain the relationship between their philosophical views on games and physical exercises related to body and soul. The research method was descriptive-analytical. The research findings showed that despite the differences in the philosophical thought of Ibn Sina and Ghazali, in the field of proofs of the soul and the body, there is a similarity between these two thinkers and the relationship between the soul and the body is two-ways. With physical activity in the game, there is an effect on the soul and vice versa. In fact, whenever playing and exercising are done in proportion and the body is active, then the soul will also have fun, and this is based on the effect that the body has on the soul. According to the theory of two thinkers, such a conclusion is that games and physical exercises recreate energy and rejuvenates the body and soul

Content-Adaptive Variable Framerate Encoding Scheme for Green Live Streaming

Adaptive live video streaming applications use a fixed predefined configuration for the bitrate ladder with constant framerate and encoding presets in a session. However, selecting optimized framerates and presets for every bitrate ladder representation can enhance perceptual quality, improve computational resource allocation, and thus, the streaming energy efficiency. In particular, low framerates for low-bitrate representations reduce compression artifacts and decrease encoding energy consumption. In addition, an optimized preset may lead to improved compression efficiency. To this light, this paper proposes a Content-adaptive Variable Framerate (CVFR) encoding scheme, which offers two modes of operation: ecological (ECO) and high-quality (HQ). CVFR-ECO optimizes for the highest encoding energy savings by predicting the optimized framerate for each representation in the bitrate ladder. CVFR-HQ takes it further by predicting each representation's optimized framerate-encoding preset pair using low-complexity discrete cosine transform energy-based spatial and temporal features for compression efficiency and sustainable storage. We demonstrate the advantage of CVFR using the x264 open-source video encoder. The results show that CVFR-ECO yields an average PSNR and VMAF increase of 0.02 dB and 2.50 points, respectively, for the same bitrate, compared to the fastest preset highest framerate encoding. CVFR-ECO also yields an average encoding and storage energy consumption reduction of 34.54% and 76.24%, considering a just noticeable difference (JND) of six VMAF points. In comparison, CVFR-HQ yields an average increase in PSNR and VMAF of 2.43 dB and 10.14 points, respectively, for the same bitrate. Finally, CVFR-HQ resulted in an average reduction in storage energy consumption of 83.18%, considering a JND of six VMAF points

Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease.

BACKGROUND: Environmental enrichment (EE) in laboratory animals improves neurological function and motor/cognitive performance, and is proposed as a strategy for treating neurodegenerative diseases. EE has been investigated in the R6/2 mouse model of Huntington's disease (HD), where increased social interaction, sensory stimulation, exploration, and physical activity improved survival. We have also shown previously that HD patients and R6/2 mice have disrupted circadian rhythms, treatment of which may improve cognition, general health, and survival. METHODOLOGY/PRINCIPAL FINDINGS: We examined the effects of EE on the behavioral phenotype and circadian activity of R6/2 mice. Our mice are typically housed in an "enriched" environment, so the EE that the mice received was in addition to these enhanced housing conditions. Mice were either kept in their home cages or exposed daily to the EE (a large playground box containing running wheels and other toys). The "home cage" and "playground" groups were subdivided into "handling" (stimulated throughout the experimental period) and "no-handling" groups. All mice were assessed for survival, body weight, and cognitive performance in the Morris water maze (MWM). Mice in the playground groups were more active throughout the enrichment period than home cage mice. Furthermore, R6/2 mice in the EE/no-handling groups had better survival than those in the home cage/no-handling groups. Sex differences were seen in response to EE. Handling was detrimental to R6/2 female mice, but EE increased the body weight of male R6/2 and WT mice in the handling group. EE combined with handling significantly improved MWM performance in female, but not male, R6/2 mice. CONCLUSIONS/SIGNIFICANCE: We show that even when mice are living in an enriched home cage, further EE had beneficial effects. However, the improvements in cognition and survival vary with sex and genotype. These results indicate that EE may improve the quality of life of HD patients, but we suggest that EE as a therapy should be tailored to individuals

Biosynthesized Silver Nanoparticle (AgNP) From Pandanus odorifer Leaf Extract Exhibits Anti-metastasis and Anti-biofilm Potentials

Cancer and the associated secondary bacterial infections are leading cause of mortality, due to the paucity of effective drugs. Here, we have synthesized silver nanoparticles (AgNPs) from organic resource and confirmed their anti-cancer and anti-microbial potentials. Microwave irradiation method was employed to synthesize AgNPs using Pandanus odorifer leaf extract. Anti-cancer potential of AgNPs was evaluated by scratch assay on the monolayer of rat basophilic leukemia (RBL) cells, indicating that the synthesized AgNPs inhibit the migration of RBL cells. The synthesized AgNPs showed MIC value of 4–16 µg/mL against both Gram +ve and Gram -ve bacterial strains, exhibiting the anti-microbial potential. Biofilm inhibition was recorded at sub- MIC values against Gram +ve and Gram -ve bacterial strains. Violacein and alginate productions were reduced by 89.6 and 75.6%, respectively at 4 and 8 µg/mL of AgNPs, suggesting anti-quorum sensing activity. Exopolysaccharide production was decreased by 61–79 and 84% for Gram +ve and Gram -ve pathogens respectively. Flagellar driven swarming mobility was also reduced significantly. Furthermore, In vivo study confirmed their tolerability in mice, indicating their clinical perspective. Collective, we claim that the synthesized AgNPs have anti-metastasis as well as anti-microbial activities. Hence, this can be further tested for therapeutic options to treat cancer and secondary bacterial infections

Biosynthesized Silver Nanoparticle (AgNP) From Pandanus odorifer Leaf Extract Exhibits Anti-metastasis and Anti-biofilm Potentials

Cancer and the associated secondary bacterial infections are leading cause of mortality, due to the paucity of effective drugs. Here, we have synthesized silver nanoparticles (AgNPs) from organic resource and confirmed their anti-cancer and anti-microbial potentials. Microwave irradiation method was employed to synthesize AgNPs using Pandanus odorifer leaf extract. Anti-cancer potential of AgNPs was evaluated by scratch assay on the monolayer of rat basophilic leukemia (RBL) cells, indicating that the synthesized AgNPs inhibit the migration of RBL cells. The synthesized AgNPs showed MIC value of 4–16 µg/mL against both Gram +ve and Gram -ve bacterial strains, exhibiting the anti-microbial potential. Biofilm inhibition was recorded at sub- MIC values against Gram +ve and Gram -ve bacterial strains. Violacein and alginate productions were reduced by 89.6 and 75.6%, respectively at 4 and 8 µg/mL of AgNPs, suggesting anti-quorum sensing activity. Exopolysaccharide production was decreased by 61–79 and 84% for Gram +ve and Gram -ve pathogens respectively. Flagellar driven swarming mobility was also reduced significantly. Furthermore, In vivo study confirmed their tolerability in mice, indicating their clinical perspective. Collective, we claim that the synthesized AgNPs have anti-metastasis as well as anti-microbial activities. Hence, this can be further tested for therapeutic options to treat cancer and secondary bacterial infections

Assessment of blended learning for teaching dental anatomy to dentistry students

Objectives: Blended learning (BL) combines conventional face to face (F2F) sessions with online educational resources. This method includes the advantages of online course delivery without the omission of conventional F2F interaction. The purpose of the present study was to evaluate students\u27 satisfaction and educational outcomes in a BL course compared to traditionally administered dental anatomy course.Methods: A prospective non-randomized study was conducted to compare the outcomes and perception of BL for teaching dental anatomy to dental students. First year dental anatomy students (n = 98) were included (48 in the conventional F2F learning and 50 in the BL group). Multiple choice questions were used to assess the achievement of learning outcomes and the Dundee Ready Education Environment Measure (DREEM) to determine the educational environment during the course.Results: There was no significant difference in the pre-test scores of both groups; however the mean post-test score for the BL group (31.5 ± 4.5) was significantly higher than the F2F group (27.2 ± 4.9). The post-test scores were comparable across both genders in the BL group while females secured significantly higher scores than males in the F2F group. The DREEM scores were also significantly higher in the BL group (147.3 ± 15.5) than the F2F group (134.5 ± 15.1) (p \u3c 0.002). A similar pattern was observed in DREEM subscales.Conclusions: The BL course is associated with improved students\u27 satisfaction and learner achievement compared to a conventionally administered dental anatomy course. In addition, BL enhanced students\u27 accessibility, self-assessment, and higher level of engagement compared to F2F delivery of the course

Analysis of Web-Based IoT through Heterogeneous Networks: Swarm Computing over LoRaWAN

The Internet of Things (IoT) leverages added valued services by the wide spread of connected smart devices. The Swarm Computing paradigm considers a single abstraction layer that connects all kinds of devices globally, from sensors to super computers. In this context, the Low-Power Wide-Area Network (LPWAN) emerges, spreading out connection to the IoT end devices. With the upsides of long-range, low power and low cost, LPWAN presents major limitations regarding data transmission capacity, throughput, supported packet length and quantity per day limitation. This situation makes LPWAN systems with limited interoperability integrate with systems based on REpresentational State Transfer (REST). This work investigates how to connect web-based IoT applications with LPWANs. The analysis was carried out studying the number of packets generated for a use case of REST-based IoT over LPWAN, specifically the Swarm OS over LoRaWAN. The work also presents an analysis of the impact of using promising schemes for lower communication load. We evaluated Constrained Application Protocol (CoAP), Static Context Header Compression (SCHC) and Concise Binary Object Representation (CBOR) to make transmission over the restricted links of LPWANs possible. The attained results show the reduction of 98.18% packet sizes while using SCHC and CBOR compared to HTTP and JSON by sending fewer packets with smaller sizes