Study of the Effect of Garlic on Serum Lipids and Blood Glucose Levels in Type 2 Diabetic Patients

Introduction: Hyperlipidemia and diabetes are common risk factors for ischemic heart disease, which is the main cause of mortality in diabetic patients. Strict control of blood glucose and other risk factors in diabetics has led to prevention of complications. Garlic has received particular attention for control of blood glucose and decrease in blood lipid levels. At present, several studies have been carried out in order to prove advantages of garlic. Methods: In this study, effects of garsin (a derivative of garlic present in our country) on serum lipids and blood glucose levels in diabetes mellitus type 2 patients was observed. Forty-five type 2 diabetics who had hyperlipidemia were selected. These patients were kept on treatment with 3 tablets of Garsin / day for 4 weeks. Serum lipids and blood glucose levels were measured prior to and at the end of treatment. Results: Relationship between sex and response to treatment in this study was meaningful, such that Gsarsin led to decrease in LDL-C and increase in HDL in females. Conclusion: Therefore, Garsin can be used as an adjunct to treatment in diabetes type 2 patients with hyperlipidemia

Prevalence of microalbuminuria and its risk factors in type 2 diabetic patients

A cross-sectional study was performed from November 2005 to July 2007 to determine the prevalence of microalbuminuria and its risk factors among type 2 diabetic patients.. Two hundred and eighty-eight type 2 diabetic patients (141 males and 147 females) referred to Yazd diabetes research center were randomly recruited for the study. Microalbuminuria was detected by measuring the albumin to creatinine ratio in the early morning urine. Microalbuminuria was diagnosed if this ratio was between 30 and 300 mg/g on two occasions during three months. Prevalence of microalbuminuria was 14.2%. Chi-square analysis revealed that microalbuminuria was correlated with the diastolic blood pressure (P = 0.003) and the duration of diabetes (P = 0.000). No statistically significant correlation was found between microalbuminuria and age, sex, body mass index, levels of fasting blood sugar, glycosylated hemoglobin (HbA1c), serum triglyceride, and serum cholesterol, or systolic blood pressure. For 240 patients for whom the duration of diabetes was known from the answers in their questionnaires, logistic regression was used for analysis. Results showed that two variables including the duration of diabetes and Diastolic Blood Pressure (DBP) play a role in this model and the following Logic association was obtained: g^ (x) = -9.233 ± 0.079 DBP ± 0.114 duration according to this model, both DBP and duration of diabetes were directly correlated with microalbuminuria. Determination of the urine albumin to creatinine ratio is an easy method for screening of microalbuminuria that is suggested for all diabetic patients, especially diabetic patients with hypertension and long-term diabetes

Study of Blood Leptin Levels before and After Treatment with Metformin in Diabetes Type Ii Patients

Introduction: Leptin is a fat tissue hormone that has 176 amino acids with a molecular weight of 16 KD . Leptin has effects on the hypothalamus and peripheral tissues resulting in decreased food absorption and increased energy consumption that finally reduces the body weight and BMI. The aim of this research was to investigate the blood levels of leptin before and after treatment with Metformin in type II diabetic patients. Methods: 25 type II diabetic patients without any previous drug treatment history were investigated. This study was a clinical trail before and after treatment with Metformin. Results: There was no particular difference in BMI, average body weight, fat mass and free fat mass before and after treatment. Similarly, the difference in concentration levels of blood glucose, cholesterol, tri-glycerides and LDL-cholesterol before and after treatment was not statistically significant. Also, there was no difference in the average concentration of leptin and insulin before and after treatment Conclusion: This result showed that although metformin decreased glucose and lipid levels during the treatment period, (1 month) it did not have an effect on leptin, Insulin and other related factors during treatment.

Effect of vitamin E on glycemic control and lipid profile in type 2 diabetes

Background: Type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic patients. Also some studies showed that vitamin E enhances insulin sensitivity and improves lipid profile. The aim of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type 2 diabetic patients. Materials and Methods: In this study 31 type 2 diabetic subject who referred to Yazd Diabetes Research Center with Fasting blood suger:140-200 mg/dl,2-hour postprandial BS <250 md/dl, Triglyceride <400mg/dl, Total Cholesterol ≤300 mg/dl and mild hypertension (systolic blood pressure: 140-160mmHg,diastolic BP:90-100mmHg) were selected. Subjects received vitamin E 800 IU/day for 3 months. At first and end of treatment period FBS, TC, TG, LDL, HDL, Glycated hemoglobin and fasting insulin level were measured. Results: In this study 31 type 2 diabetic patients (19 female, 12 male) with mean age 53.03 ± 8.87 years and mean duration of diabetes 2.16 ± 0.89 years were studied. Vitamin E supplementation for 3 months had no positive effect on type 2 diabetic patients. As FBS, TG and fasting insulin decreased but this decline was not significant. Also TC levels, systolic and diastolic BP changes was not remarkable. Conclusion: Results of this study showed that 800 IU vitamin E administration for 3 months could not improve blood glucose, lipids, HbA1C, fasting insulin, systolic and diastolic BP in type 2 diabetic patients

Effect of two supplementary zinc regimens on serum lipids oxidizability in type II diabetic patients

Background: Chronic complications (e.g. cardiovascular failure) are among the most common problems in diabetics. It is suggested that oxidative stress and lipid peroxidation play a key role in chronic diabetic complications. Supplementation with agents containing antioxidant properties can suppress lipid peroxidation. Many studies confirmed the antioxidant properties of zinc in biological systems. The aim of the present study was to evaluate the effect of zinc supplements on serum lipid oxidizability in diabetic patients. Materials and Methods: In this clinical trial study, 60 diabetic patients were chosen and randomly divided into two groups. Serum lipid oxidizability and serum zinc level were evaluated in each group before and after zinc supplementation (25.50 mg/day for 2 month). Lipid oxidizability was followed through monitoring the change of conjugated compounds in diluted serum after adding Cu2+ by spectrophotometric method. S erum zinc level was measured by atomic absorbance spectrophotometer. Results: While there was no significant change in the post- supplementation zinc level (25 mg) in the first group, zinc serum level was increased significantly (