105 research outputs found
Clinical-economic analysis of valproate microsphere form in focal epilepsy in adults (real world evidences)
Clinical and economical results of switching from original valproate - Depakine Chronosphere - to generic tablets of prolong action in adult patients with focal epilepsy has been performed. Methodology: In 127 patients duration of Depakine Chronosphere usage before switching, itβs dosage, efficacy, drug of switching, itβs dosage, dynamic of epilepsy seizures during half of the year after were fixed. Also were calculated total amount of out-patients visits, emergency calls, admission to hospitals, disability days before and after switching. Direct costs, including pharmacotherapy, hospitalization, out-patients visits etc., have been summarized. And total expenditures for one patient were calculated with cost-effective ratio during half of the year before and after switching were ensured. Results: Adult patients with focal epilepsy (127 pts) have been switched by doctors for technical, non medical, reasons to receive valproate Gxs instead previous treatment with Depakine Chronosphere. Patients have switched to Convulex (n=79.), Encorat (n= 27), Valparin Π₯Π (n=21). After Convulex switching the total amount of patients in remission is less than in Depakine treatment. Absolute Risk of seizures is increased on 16,5%, relative risk - on 27,7%. Total amount of out-patientsβ visits increased on 47,2% by the less Convulex efficacy as well as necessity in hospitalization has been occurred, and disability days count was 3,35 in average after switching. Total expenditures after switching from Depakine Chronosphere to Convulex were increased, and cost-effective ration for Depakine Chronosphere was less on 80,4% in compare with Convulex. In other cases of switching from original to Gxs valproate results were similar - efficacy was less and cost was increased. Conclusion: Switch from Depakine Chronosphere to valproate Gxs in focal epilepsy in adults is not justified from clinical point of view and more expensive from economic point of view
Investigation of wound healing activity of the flavonoid schaftoside isolated from Lychnis chalcedonica
Study for the first time shows a pronounced wound healing effect from aqueous solution of the flavonoid schaftoside from LyΡhnis chalcedonica on the model of a plane skin wound in mic
Implementation of Youth Initiatives of Youth with Disabilities
The purpose of the article is to study the opinions of young people with disabilities regarding the possibility of realizing themselves, their capabilities and initiatives. To achieve this goal, the methods of theoretical analysis, questionnaires of young people with restricted health opportunities (All-russian society of the deaf) were used. the survey results showed that youth with organic health opportunities in their localities need youth organizations. The main goals and functions of youth organizations for young people with disabilities difficult life situations.Π¦Π΅Π»ΡΡ ΡΡΠ°ΡΡΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ½Π΅Π½ΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ Ρ ΠΠΠ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠ΅Π°Π»ΠΈΠ·ΠΎΠ²Π°ΡΡ ΡΠ΅Π±Ρ, ΡΠ²ΠΎΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈ ΠΈΠ½ΠΈΡΠΈΠ°ΡΠΈΠ²Ρ. ΠΠ»Ρ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ ΡΠ΅Π»ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°, Π°Π½ΠΊΠ΅ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ Ρ ΠΠΠ (ΠΠΠ). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΠΏΡΠΎΡΠ° ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΡ Ρ ΠΠΠ Π² ΡΠ²ΠΈΡ
Π½Π°ΡΠ΅Π»Π΅Π½Π½ΡΡ
ΠΏΡΠ½ΠΊΡΠ°Ρ
Π½ΡΠΆΠ΄Π°Π΅ΡΡΡ Π² ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡΡ
. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΠ΅Π»ΠΈ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ Π΄Π»Ρ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ Ρ ΠΠΠ (ΠΠΠ): ΠΎΠΊΠ°Π·Π°Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΠΌ ΠΈΠ½Π²Π°Π»ΠΈΠ΄Π°ΠΌ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π²ΠΎΠΏΡΠΎΡΠΎΠ², ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ ΡΡΡΠ΄ΠΎ-ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ, ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ Π΄ΠΎΡΡΠ³ΠΎΠ²ΡΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ»ΠΎΠΆΠ½ΡΡ
ΠΆΠΈΠ·Π½Π΅Π½Π½ΡΡ
ΡΠΈΡΡ-ΡΠΈΠΉ
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΉ ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ , ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ Π½ΠΎΠ²ΡΡ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ COVID-19
The objective was to determine the most significant categories of ICF that allow us to provide objective information about the biopsychosocial state of patients who have suffered a new coronavirus infection COVID-19 and to choose the most effective methods of rehabilitation based on the rehabilitation diagnosis of each group of patients.Methods and materials. On the basis of the clinic of the Pavlov University, a course of medical rehabilitation was conducted for 2 weeks for patients who had suffered a new coronavirus infection in severe and moderate degree of course. 2 groups were formed: EG1-25 people participating in the rehabilitation program with the use of physical exercises and EG2 β 39 people with the use of physical exercises and physiotherapy. A categorical rehabilitation profile of patients by ICF domains was compiled.Results. As a result of the application of the medical rehabilitation program, a statistically significant improvement in the indicators in EG 2 was revealed. The respiratory function (the Barbell test) improved by 14.6%, the functional state of the cardiovascular system according to the DBP indicator by 3.9%. The analysis of the results of the ICF category Β«activity and participationΒ» revealed a statistically significant improvement in the motor test parameters (6MSHT) in both groups: by 11.9 % in EG2 and by 20.6 % in EG1.Conclusions. The results of the study indicate the positive impact of the proposed program of medical rehabilitation and confirm the relevance of the problem, unsolved problems and prospects for scientific research on this topic.Π¦Π΅Π»Ρ β ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ (ΠΠΠ€), ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ Π΄Π°ΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ Π±ΠΈΠΎΠΏΡΠΈΡ
ΠΎΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΌ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ
Π½ΠΎΠ²ΡΡ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ COVID-19, ΠΈ Π²ΡΠ±ΡΠ°ΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΊΠ°ΠΆΠ΄ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π±ΠΎΠ»ΡΠ½ΡΡ
.ΠΠ΅ΡΠΎΠ΄Ρ ΠΈ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ. ΠΠ° Π±Π°Π·Π΅ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΈ ΠΠ‘ΠΠ±ΠΠΠ£ ΠΈΠΌ. Π. Π. ΠΠ°Π²Π»ΠΎΠ²Π° Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 2 Π½Π΅Π΄Π΅Π»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΊΡΡΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ, ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΠΌ Π½ΠΎΠ²ΡΡ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ Π² ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΈ ΡΡΠ΅Π΄Π½Π΅ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ. Π‘ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Ρ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ: ΠΠ1 β 25 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΡ
Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΏΡΠ°ΠΆΠ½Π΅Π½ΠΈΠΉ, ΠΈ ΠΠ2 β 39 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΏΡΠ°ΠΆΠ½Π΅Π½ΠΈΠΉ ΠΈ ΡΠΈΠ·ΠΈΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ. Π‘ΠΎΡΡΠ°Π²Π»Π΅Π½ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎ Π΄ΠΎΠΌΠ΅Π½Π°ΠΌ ΠΠΠ€.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠΌ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π² ΠΠ 2. Π€ΡΠ½ΠΊΡΠΈΡ Π΄ΡΡ
Π°Π½ΠΈΡ (ΠΏΡΠΎΠ±Π° Π¨ΡΠ°Π½Π³Π΅) ΡΠ»ΡΡΡΠΈΠ»Π°ΡΡ Π½Π° 14,6 %, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΠΠΠ β Π½Π° 3,9 %. ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΠΠ€ Β«ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΡΡΠ°ΡΡΠΈΠ΅Β» Π²ΡΡΠ²ΠΈΠ» ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Ρ (6ΠΠ¨Π’) Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
: Π½Π° 11,9 % Π² ΠΠ2 ΠΈ Π½Π° 20,6 % Π² ΠΠ1.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ, Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΈ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π² ΠΠ2. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π΄Π°Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, Π½Π΅ΡΠ΅ΡΠ΅Π½Π½ΡΠ΅ Π·Π°Π΄Π°ΡΠΈ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ Π½Π°ΡΡΠ½ΡΡ
ΠΈΠ·ΡΡΠΊΠ°Π½ΠΈΠΉ ΠΏΠΎ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ΅ΠΌΠ΅
The inflammation markers in serum of tumor-bearing rats after plasmonic photothermal therapy
We report on plasmonic photothermal therapy of rats with inoculated cholangiocarcinoma through the intratumoral injection of PEG-coated gold nanorods followed by CW laser light irradiation. The length and diameter of gold nanorods were 41Β±8 nm and 10Β±2 nm, respectively; the particle mass-volume concentration was 400 ΞΌg/mL, which corresponds to the optical density of 20 at the wavelength 808 nm. The tumor-bearing rats were randomly divided into three groups: (1) without any treatment (control); (2) with only laser irradiation of tumor; (3) with intratumoral administration of gold nanorods and laser irradiation of tumors. An hour before laser irradiation, the animals were injected intratumorally with gold nanorod solutions in the amount of 30% of the tumor volume. The infrared 808-nm laser with power density of 2.3 W/cm2 was used for plasmonic photothermal therapy (PTT). The withdraw of animals from the experiment was performed 24 h after laser exposure. The content of lipid peroxidation products and molecular markers of inflammation (TNF-Ξ±, IGF-1, VEGF-C) was determined by ELISA test in serum of rats. The standard histological techniques with hematoxylin and eosin staining were used for morphological examination of tumor tissues. It was revealed that the significant necrotic changes were noted in tumor tissue after plasmonic photothermal therapy, which were accompanied by formation of inflammatory reaction with release of proinflammatory cytokines and lipid peroxidation products into the bloodstream
ΠΠΠ’-ΠΠ’ ΠΠΠ Π’ΠΠΠ ΠΠΠ‘Π‘ΠΠΠΠΠΠ¦ΠΠ ΠΠΠΠ ΠΠΠΠ§ΠΠ‘Π’ΠΠΠΠΠΠ ΠΠΠΠΠΠΠΠΠ«
The ability to metastasize is considered to be one of the key features of malignant tumors. However, the literature describes the possibility of dissemination of histologically verified benign tumors β uterine leiomyoma. Diagnosis of metastatic leiomyoma is a challenging task for the doctor, due to the extreme rarity of this disease, at the same time revealing the purity of the process is determining the further tactics of treatment, significantly different from the treatment of malignancies. Case report. We presented a rare case of dissemination of benign tumors β leiomyomas. The female patient of 72 years old had signs of typical malignant tumors of the ovaries, such as nodules of the abdominal cavity, ascites and metastases in the body of the lumbar vertebra, increased level of CA-125. PET-CT revealed increased FDG uptake in soft-tissue neoplasm that destruct the body of the lumbar vertebrae and the nodules in the abdominal cavity with increased metabolic activity, typical for malignant tumors. However, histological examination with immunohistochemical verification confirmed the presence of dissemination of benign tumors. Conclusion. The presence of signs, typical for the malignant tumor, such as the presence of distant metastases of various localizations, a high level of CA-125 tumor marker, increased metabolic activity on PET scan in rare cases, may occur with benign tumors. Therefore, diagnosis of tumors should always be integrated, with the obligatory account all available clinical, laboratory and instrumental data.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. Π‘ΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΊ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΈΡΠ°Π΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΊΠ»ΡΡΠ΅Π²ΡΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ. ΠΠ΄Π½Π°ΠΊΠΎ Π² Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½Π°ΡΠΈΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ β Π»Π΅ΠΉΠΎΠΌΠΈΠΎΠΌ ΠΌΠ°ΡΠΊΠΈ. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΡΡΡΠ΅ΠΉ Π»Π΅ΠΉΠΎΠΌΠΈΠΎΠΌΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΠΈΠ·-Π·Π° ΠΈΡΠΊΠ»ΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅Π΄ΠΊΠΎΡΡΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π² ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΡΠ°ΠΊΡΠΈΠΊΡ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ ΠΎΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ»ΡΡΠ°Ρ. ΠΡΠΈΠ²ΠΎΠ΄ΠΈΠΌ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΡΠ΅Π΄ΠΊΠΎΠ³ΠΎ ΡΠ»ΡΡΠ°Ρ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½Π°ΡΠΈΠΈ Π»Π΅ΠΉΠΎΠΌΠΈΠΎΠΌΡ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ 72 Π»Π΅Ρ ΠΈΠΌΠ΅Π»ΠΈΡΡ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ, ΡΠΈΠΏΠΈΡΠ½ΡΠ΅ Π΄Π»Ρ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΠ½ΠΈΠΊΠΎΠ²: ΡΠ·Π»ΠΎΠ²ΡΠ΅ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΡΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ, Π°ΡΡΠΈΡ, ΠΌΠ΅ΡΠ°ΡΡΠ°Π· Π² ΡΠ΅Π»ΠΎ ΠΏΠΎΡΡΠ½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ·Π²ΠΎΠ½ΠΊΠ°, Π²ΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π‘Π-125. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΠΠ’-ΠΠ’ Π² ΠΌΡΠ³ΠΊΠΎΡΠΊΠ°Π½Π½ΠΎΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ, ΡΠ°Π·ΡΡΡΠ°ΡΡΠ΅ΠΌ ΡΠ΅Π»ΠΎ ΠΏΠΎΡΡΠ½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ·Π²ΠΎΠ½ΠΊΠ°, ΠΈ ΠΊΡΡΠΏΠ½Π΅ΠΉΡΠ΅ΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ Π±ΡΡΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΠΈΠΌΠ΅Π»ΠΎΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΡΠΈΠΏΠΈΡΠ½ΠΎΠ΅ Π΄Π»Ρ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ. ΠΠ΄Π½Π°ΠΊΠΎ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½Π°ΡΠΈΡ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ², ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΡ
ΠΎ Π½Π°Π»ΠΈΡΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Ρ ΠΈ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΠΎΠ½ΠΊΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ° Π‘Π-125, ΠΏΠΎΠ²ΡΡΠ΅Π½Π½Π°Ρ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΠΠ’ Π² ΡΠ΅Π΄ΠΊΠΈΡ
ΡΠ»ΡΡΠ°ΡΡ
ΠΌΠΎΠΆΠ΅Ρ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ ΠΏΡΠΈ Π΄ΠΎΠ±ΡΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
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