Evolution of socio-cultural policy mapping of city community design for city sociocultural space

The aim of this study is to carry out a comprehensive analysis tools for mapping communities in the context of the modernization upgrade the socio-cultural space of present-day Ukrainian city. Methodology of research: To accomplish the tasks, the following general scientific and empirical methods were used such as: analysis, synthesis, comparison, systematization, generalization, as well as questionnaires, focus group research and method «World café». To analyze the development and implementation of communities mapping projects in the modern city, we are involved with axiological and activity approaches. The method of cultural mapping of the city of participatory type based on the city of Melitopol is developed. The scientific novelty of the study is an interdisciplinary correlative-integrative approach to the study of the problem of mapping, modernization and sustainable socio-cultural development of the modern Ukrainian city, which combines the cultural, philosophical and sociological principles of analysis and consists in an attempt of a culturally-analytical comprehensive study of ways of organizing the cooperation of the urban community with local self-government bodies. Conclusions. In this study, an attempt was made not only to characterize the mapping of the community as a method, but also to identify the possibilities of its use for the study of the socio-territorial space, to determine its practical significance, which, in our opinion, may serve as a scientific basis not only for knowledge, forecasting of urban socio-cultural processes, but also will contribute to the development of the communityʼs potential, the construction of the territorial organization of local self-government

Small telescopes being effective: MAGIC or not?

The paper describes the MAGIC multi-mode focal reducer (Monitoring of Active Galaxies by Investigation of their Cores), commissioned on the 1-m Zeiss-1000 telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences in September 2020. Three observational modes are currently realised: photometry, polarimetry, and long-slit spectroscopy. Reducing the focal length makes it possible to obtain a sufficiently large field of view for photometry and a large slit height for spectroscopy of $\sim$12$'$, as well as a large field of view for polarimetry with a quadrupole Wollaston prism of $\sim$6$'$.4. This feature makes the complex study of extended nebulae and galaxies efficient. The MAGIC capabilities are presented in examples of observations of various astronomical objects. The spectral mode in the range of 4000-7200 AA provides the spectral resolution $R \sim$ 1000; for a starlike target up to 14 mag in medium-band filters with a seeing of 1$''$ for 20 minutes of total exposure, the photometry accuracy is better than 0.01 mag and the polarization accuracy is better than 0.6%. Especially for the new focal reducer, an offset guide and a position angle rotation system were implemented. The results of the modernization of the baffle system in the optical scheme of the telescope for the suppression of scattered light are also described

γ spectroscopy of states in Cl 32 relevant for the S 31 (p,γ) Cl 32 reaction rate

Background: The S31(p,γ)Cl32 reaction becomes important for sulfur production in novae if the P31(p,α)Si28 reaction rate is somewhat greater than currently accepted. The rate of the S31(p,γ)Cl32 reaction is uncertain, primarily due to the properties of resonances at Ec.m.=156 and 549 keV. Purpose: We precisely determined the excitation energies of states in Cl32 through high-resolution γ spectroscopy including the two states most important for the S31(p,γ)Cl32 reaction at nova temperatures. Method: Excited states in Cl32 were populated using the B10(Mg24,2n)Cl32 reaction with a Mg24 beam from the ATLAS facility at Argonne National Laboratory. The reaction channel of interest was selected using recoils in the Fragment Mass Analyzer, and precise level energies were determined by detecting γ rays with Gammasphere. Results: We observed γ rays from the decay of six excited states in Cl32. The excitation energies for two unbound levels at Ex=1738.1 (6) keV and 2130.5 (10) keV were determined and found to be in agreement with a previous high-precision measurement of the S32(He3,t)Cl32 reaction [1]. Conclusions: An updated S31(p,γ)Cl32 reaction rate is presented. With the excitation energies of important levels firmly established, the dominant uncertainty in the reaction rate at nova temperatures is due to the strength of the resonance corresponding to the 2131-keV state in Cl32

Use of physico-chemical properties of melt water to assess the quality of the atmosphere

The purpose of the study is detection pollution level of Yekaterinburg’s park on the grounds of physico- chemical properties of melt water.Цель исследования – на основании физико-химических свойств талой воды выявить уровень загрязнённости парков г. Екатеринбурга

Возможности мультиспиральной компьютерной томографии в диагностике рака ротовой полости и языка

The aim: to determine if the multislice computed tomography is effective in detecting the oral cavity and tongue cancer.Materials and methods. A data set from MSCT research study containing records from 243 patients aged between 19 and 89 has been analyzed. The data included personal records of two groups: 124 (51.0%) patients of the main group with the diagnosis “tongue and oral cavity cancer” and 119 (49.0%) patients the control group, receiving assessment and treatment at Oncology in-patient specialized clinic №1, during a period from 2012 to 2016 years. The findings were compared to information received from clinical, instrumental examination and morphological results.Results. Some typical CT signs of tongue and oral cavity cancer are identified as following: the asymmetry of anatomical structures; tissue densities ranging +39 HU...+43 HU (min/max −13…+86 HU); obliteration of fatty layers; the postcontrast densities increasing on 36–47 HU (min/max +26…+68 HU); the presence of a hypodense contrast agent-avoiding area; signs of additional tissue; signs of local tissue defect. Similar calculations are made for the four signs of the greatest figures in complex resulting in 97.6% sensitivity, 99.2% specificity and 98.4% accuracy. The analysis of parametric data showed a direct dependency between the degree of lymph nodes involvement and the thickness and width of the tongue tumor. Conclusion. The results of this study indicate a high diagnostic efficacy of MSCT in detecting cancer of different localization in the mouth and on the tongue, determining the area affected and the identification of local metastasis.Цель исследования: определить диагностическую эффективность мультиспиральной компьютерной томографии (МСКТ) в выявлении рака полости рта и языка.Материал и методы. Проанализированы архивные данные результатов МСКТ 243 пациентов в возрасте от 19 до 89 лет, которые были разделены на 2 группы: основная группа – 124 (51,0%) больных с диагнозом рак языка или полости рта и контрольная группа – 119 (49,0%) пациентов, проходивших обследование и лечение в ГБУЗ “ОКД №1 ДЗМ” в период с 2012 по 2016 г. Полученные данные были сопоставлены с данными клинико-инструментального осмотра, а также с данными морфологического заключения.Результаты. Выделены характерные МСКТ-признаки, встречающиеся при раке языка и полости рта: асимметрия анатомических структур, участок уплотнения тканей с плотностными характеристиками в диапазоне +39 …+43 ед.H (min/max −13…+86 ед. H), облитерация межструктурных жировых прослоек, повышение показателей плотности выявленных патологических изменений после внутривенного контрастирования в среднем на 36–47 ед.H (26–68 ед.H), наличие гиподенсной зоны, не накапливающей контрастный препарат, наличие признака дополнительной ткани, наличие признака локального дефекта тканей. Рассчитаны показатели чувствительности, специфичности, точности для каждого признака. Аналогичные расчеты произведены для четырех признаков с наибольшими показателями в совокупности. Чувствительность составила 97,6%, специфичность – 99,2%, точность – 98,4%. Анализ параметрических данных размеров опухолей показал зависимость поражения лимфатических узлов от толщины и ширины опухоли языка.Заключение. Результаты данного исследования свидетельствуют о высокой диагностической эффективности МСКТ в выявлении рака различной локализации в полости рта и на языке, определении площади поражения и выявлении локального метастазирования

Studying X-ray burst nucleosynthesis in the laboratory

Type I X-ray bursts are the most common explosions in the Galaxy; however, the nucleosynthesis that occurs during the thermonuclear runaway and explosion is poorly understood. In this proceedings we discuss current experimental efforts and techniques that are being used to study X-ray burst nucleosynthesis in the laboratory. Specifically, radioactive ion beam techniques that have recently been developed have allowed the study of some of the most important (α, p) reactions in X-ray bursts for the first time. © Published under licence by IOP Publishing Ltd

Inter-Allelic Prion Propagation Reveals Conformational Relationships among a Multitude of [PSI] Strains

Immense diversity of prion strains is observed, but its underlying mechanism is less clear. Three [PSI] prion strains—named VH, VK, and VL—were previously isolated in the wild-type yeast genetic background. Here we report the generation and characterization of eight new [PSI] isolates, obtained by propagating the wild-type strains with Sup35 proteins containing single amino-acid alterations. The VH strain splits into two distinct strains when propagated in each of the three genetic backgrounds, harboring respectively single mutations of N21L, R28P, and Gi47 (i.e. insertion of a glycine residue at position 47) on the Sup35 N-terminal prion-forming segment. The six new strains exhibit complex inter-conversion patterns, and one of them continuously mutates into another. However, when they are introduced back into the wild-type background, all 6 strains revert to the VH strain. We obtain two more [PSI] isolates by propagating VK and VL with the Gi47 and N21L backgrounds, respectively. The two isolates do not transmit to other mutant backgrounds but revert to their parental strains in the wild-type background. Our data indicate that a large number of [PSI] strains can be built on three basic Sup35 amyloid structures. It is proposed that the three basic structures differ by chain folding topologies, and sub-strains with the same topology differ in distinct ways by local structural adjustments. This “large number of variations on a small number of basic themes” may also be operative in generating strain diversities in other prion elements. It thus suggests a possible general scheme to classify a multitude of prion strains

Peptides Derived from HIV-1 Integrase that Bind Rev Stimulate Viral Genome Integration

The human immunodeficiency virus type 1 (HIV-1) integrase protein (IN), catalyzes the integration of viral DNA into the host cell genome. IN catalyzes the first step of the integration process, namely the 3′-end processing in which IN removes a pGT dinucleotide from the 3′ end of each viral long terminal repeat (LTR). Following nuclear import of the viral preintegration complex, the host chromosomal DNA becomes accessible to the viral cDNA and the second step of the integration process, namely the strand-transfer step takes place. This ordered sequence of events, centered on integration, is mandatory for HIV replication. assay system, we show that INr-1 and INr-2 are able to abrogate the inhibitory effects exerted by Rev and Rev-derived peptides on integrase activity. Both INr-1 and INr-2 were found to be cell-permeable and nontoxic, allowing a study of their effect in HIV-1-infected cultured cells. Interestingly, both INr peptides stimulated virus infectivity as estimated by production of the viral P24 protein, as well as by determination of the appearance of newly formed virus particles. Furthermore, kinetics studies revealed that the cell-permeable INr peptides enhance the integration process, as was indeed confirmed by direct determination of viral DNA integration by real-time PCR.The results of the present study raise the possibility that in HIV-infected cells, the Rev protein may be involved in the integration of proviral DNA by controlling/regulating the activity of the integrase. Release from such inhibition leads to stimulation of IN activity and multiple viral DNA integration events