Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil

Dengue fever, chikungunya fever, and zika virus infections are increasing public health problems in the world, the last two diseases having recently emerged in Brazil. This ecological study employed spatial analysis of probable cases of dengue fever, chikungunya fever, and zika virus infections reported to the National Mandatory Reporting System (SINAN) in Maranhao State from 2015 to 2016. The software GeoDa version 1.10 was used for calculating global and local Moran indices. The global Moran index identified a significant autocorrelation of incidence rates of dengue (I=0.10; p=0.009) and zika (I=0.07; p=0.03). The study found a positive spatial correlation between dengue and the population density (I=0.31; p<0.001) and a negative correlation with the Performance Index of Unified Health System (PIUHS) by basic care coverage (I=-0.08; p=0.01). Regarding chikungunya fever, there were positive spatial correlations with the population density (I=0.06; p=0.03) and the Municipal Human Development Index (MHDI) (I=0.10; p=0.002), and a negative correlation with the Gini index (I=-0.01; p<0.001) and the PIUHS by basic care coverage (I=-0.18; p<0.001). Lastly, we found positive spatial correlations between Zika virus infections and the population density (I=0.13; p=0.005) and the MHDI (I=0.12; p<0.001), as well as a negative correlation with the Gini index (I=-0.11; p<0.001) and the PIUHS by basic care coverage (I=-0.05; p=0.03). Our results suggest that several socio-demographic factors influenced the occurrence of dengue fever, chikungunya fever, and zika virus infections in Maranhao State

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

Spatial analysis of probable cases of dengue fever, chikungunya fever and zika virus infections in Maranhao State, Brazil

ABSTRACT Dengue fever, chikungunya fever, and zika virus infections are increasing public health problems in the world, the last two diseases having recently emerged in Brazil. This ecological study employed spatial analysis of probable cases of dengue fever, chikungunya fever, and zika virus infections reported to the National Mandatory Reporting System (SINAN) in Maranhao State from 2015 to 2016. The software GeoDa version 1.10 was used for calculating global and local Moran indices. The global Moran index identified a significant autocorrelation of incidence rates of dengue (I=0.10; p=0.009) and zika (I=0.07; p=0.03). The study found a positive spatial correlation between dengue and the population density (I=0.31; p<0.001) and a negative correlation with the Performance Index of Unified Health System (PIUHS) by basic care coverage (I=-0.08; p=0.01). Regarding chikungunya fever, there were positive spatial correlations with the population density (I=0.06; p=0.03) and the Municipal Human Development Index (MHDI) (I=0.10; p=0.002), and a negative correlation with the Gini index (I=-0.01; p<0.001) and the PIUHS by basic care coverage (I=-0.18; p<0.001). Lastly, we found positive spatial correlations between Zika virus infections and the population density (I=0.13; p=0.005) and the MHDI (I=0.12; p<0.001), as well as a negative correlation with the Gini index (I=-0.11; p<0.001) and the PIUHS by basic care coverage (I=-0.05; p=0.03). Our results suggest that several socio-demographic factors influenced the occurrence of dengue fever, chikungunya fever, and zika virus infections in Maranhao State

Two-pion femtoscopy in p-Pb collisions at sNN=5.02\sqrt{s_{\rm NN}}=5.02 TeV

We report the results of the femtoscopic analysis of pairs of identical pions measured in p-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$ TeV. Femtoscopic radii are determined as a function of event multiplicity and pair momentum in three spatial dimensions. As in the pp collision system, the analysis is complicated by the presence of sizable background correlation structures in addition to the femtoscopic signal. The radii increase with event multiplicity and decrease with pair transverse momentum. When taken at comparable multiplicity, the radii measured in p-Pb collisions, at high multiplicity and low pair transverse momentum, are 10-20% higher than those observed in pp collisions but below those observed in A-A collisions. The results are compared to hydrodynamic predictions at large event multiplicity as well as discussed in the context of calculations based on gluon saturation

Measurement of pion, kaon and proton production in proton-proton collisions at √s = 7 TeV

The measurement of primary π±, K±, p and p¯¯¯ production at mid-rapidity (|y|< 0.5) in proton-proton collisions at s√=7 TeV performed with ALICE (A Large Ion Collider Experiment) at the Large Hadron Collider (LHC) is reported. Particle identification is performed using the specific ionization energy loss and time-of-flight information, the ring-imaging Cherenkov technique and the kink-topology identification of weak decays of charged kaons. Transverse momentum spectra are measured from 0.1 up to 3 GeV/c for pions, from 0.2 up to 6 GeV/c for kaons and from 0.3 up to 6 GeV/c for protons. The measured spectra and particle ratios are compared with QCD-inspired models, tuned to reproduce also the earlier measurements performed at the LHC. Furthermore, the integrated particle yields and ratios as well as the average transverse momenta are compared with results at lower collision energies

Centrality dependence of particle production in p-Pb collisions at sNN\sqrt{s_{\rm NN} }= 5.02 TeV

We report measurements of the primary charged particle pseudorapidity density and transverse momentum distributions in p-Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV, and investigate their correlation with experimental observables sensitive to the centrality of the collision. Centrality classes are defined using different event activity estimators, i.e. charged particle multiplicities measured in three disjunct pseudorapidity regions as well as the energy measured at beam rapidity (zero-degree). The procedures to determine the centrality, quantified by the number of participants ($N_{\rm part}$), or the number of nucleon-nucleon binary collisions ($N_{\rm coll}$), are described. We show that, in contrast to Pb-Pb collisions, in p-Pb collisions large multiplicity fluctuations together with the small range of participants available, generate a dynamical bias in centrality classes based on particle multiplicity. We propose to use the zero-degree energy, which we expect not to introduce a dynamical bias, as an alternative event-centrality estimator. Based on zero-degree energy centrality classes, the $N_{\rm part}$ dependence of particle production is studied. Under the assumption that the multiplicity measured in the Pb-going rapidity region scales with the number of Pb-participants, an approximate independence of the multiplicity per participating nucleon measured at mid-rapitity of the number of participating nucleons is observed. Furthermore, at high-$p_{\rm T}$ the p-Pb spectra are found to be consistent with the pp spectra scaled by $N_{\rm coll}$ for all centrality classes. Our results represent valuable input for the study of the event activity dependence of hard probes in p-Pb collision and, hence, help to establish baselines for the interpretation of the Pb-Pb data

Two-pion femtoscopy in p–Pb collisions at √sNN = 5.02 TeV

We report the results of the femtoscopic analysis of pairs of identical pions measured in p-Pb collisions at sNN−−−√=5.02 TeV. Femtoscopic radii are determined as a function of event multiplicity and pair momentum in three spatial dimensions. As in the pp collision system, the analysis is complicated by the presence of sizable background correlation structures in addition to the femtoscopic signal. The radii increase with event multiplicity and decrease with pair transverse momentum. When taken at comparable multiplicity, the radii measured in p-Pb collisions, at high multiplicity and low pair transverse momentum, are 10-20% higher than those observed in pp collisions but below those observed in A-A collisions. The results are compared to hydrodynamic predictions at large event multiplicity as well as discussed in the context of calculations based on gluon saturation

Inclusive, prompt and non-prompt J/ψ\psi production at mid-rapidity in Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The transverse momentum ($p_{\rm T}$) dependence of the nuclear modification factor $R_{\rm AA}$ and the centrality dependence of the average transverse momentum $\langle p_{\rm T}\rangle$ for inclusive J/$\psi$ have been measured with ALICE for Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV in the e$^+$e$^-$ decay channel at mid-rapidity ($|y|<0.8$). The $\langle p_{\rm T}\rangle$ is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of $R_{\rm AA}$ is observed towards low $p_{\rm T}$. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/$\psi$ production. Additionally, the fraction of non-prompt J/$\psi$ from beauty hadron decays, $f_{\rm B}$, has been determined in the region $1.5 < p_{\rm T} < 10$ GeV/c in three centrality intervals. No significant centrality dependence of $f_{\rm B}$ is observed. Finally, the $R_{\rm AA}$ of non-prompt J/$\psi$ is discussed and compared with model predictions. The nuclear modification in the region $4.5 < p_{\rm T} < 10$ GeV/c is found to be stronger than predicted by most models.The transverse momentum (p$_{T}$) dependence of the nuclear modification factor R$_{AA}$ and the centrality dependence of the average transverse momentum 〈p$_{T}$〉 for inclusive J/ψ have been measured with ALICE for Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}}=2.76$ TeV in the e+e$^{−}$ decay channel at mid-rapidity (|y| < 0.8). The 〈p$_{T}$〉 is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of R$_{AA}$ is observed towards low p$_{T}$. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/ψ production. Additionally, the fraction of non-prompt J/ψ from beauty hadron decays, f$_{B}$, has been determined in the region 1.5 < p$_{T}$ < 10 GeV/c in three centrality intervals. No significant centrality dependence of f$_{B}$ is observed. Finally, the R$_{AA}$ of non-prompt J/ψ is discussed and compared with model predictions. The nuclear modification in the region 4.5 < p$_{T}$ < 10 GeV/c is found to be stronger than predicted by most models.The transverse momentum ($p_{\rm T}$) dependence of the nuclear modification factor $R_{\rm AA}$ and the centrality dependence of the average transverse momentum $\langle p_{\rm T}\rangle$ for inclusive J/$\psi$ have been measured with ALICE for Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV in the e$^+$e$^-$ decay channel at mid-rapidity ($|y|<0.8$). The $\langle p_{\rm T}\rangle$ is significantly smaller than the one observed for pp collisions at the same centre-of-mass energy. Consistently, an increase of $R_{\rm AA}$ is observed towards low $p_{\rm T}$. These observations might be indicative of a sizable contribution of charm quark coalescence to the J/$\psi$ production. Additionally, the fraction of non-prompt J/$\psi$ from beauty hadron decays, $f_{\rm B}$, has been determined in the region $1.5 < p_{\rm T} < 10$ GeV/c in three centrality intervals. No significant centrality dependence of $f_{\rm B}$ is observed. Finally, the $R_{\rm AA}$ of non-prompt J/$\psi$ is discussed and compared with model predictions. The nuclear modification in the region $4.5 < p_{\rm T} < 10$ GeV/c is found to be stronger than predicted by most models