Polynomial spline-approximation of Clarke's model

We investigate polynomial spline approximation of stationary random processes on a uniform grid applied to Clarke's model of time variations of path amplitudes in multipath fading channels with Doppler scattering. The integral mean square error (MSE) for optimal and interpolation splines is presented as a series of spectral moments. The optimal splines outperform the interpolation splines; however, as the sampling factor increases, the optimal and interpolation splines of even order tend to provide the same accuracy. To build such splines, the process to be approximated needs to be known for all time, which is impractical. Local splines, on the other hand, may be used where the process is known only over a finite interval. We first consider local splines with quasioptimal spline coefficients. Then, we derive optimal spline coefficients and investigate the error for different sets of samples used for calculating the spline coefficients. In practice, approximation with a low processing delay is of interest; we investigate local spline extrapolation with a zero-processing delay. The results of our investigation show that local spline approximation is attractive for implementation from viewpoints of both low processing delay and small approximation error; the error can be very close to the minimum error provided by optimal splines. Thus, local splines can be effectively used for channel estimation in multipath fast fading channels

Inexpensive pocket-size solar energy meter (insolometer)

Device directly measures amount of energy available in sunlight falling on the earth over range from 1 to 1250 watts per square meter. Insolometer is ideally suited to making on-site measurements of available solar energy

PND61 Cost-Utility of Fingolimod Compared With Dimethyl Fumarate (Dmf) In Highly Active Relapsing Remitting Multiple Sclerosis (Rrms) In England: Comparison of A Markov and Discrete Event Simulation Model

Numeración errónea en el original

A preliminary phylogenetic analysis of the Capsalidae (Platyhelminthes : Monogenea : Monopisthocotylea) inferred from large subunit rDNA sequences

Phylogenetic relationships within the Capsalidae (Monogenea) were examined using large subunit ribosomal DNA sequences from 17 capsalid species (representing 7 genera, 5 subfamilies), 2 outgroup taxa (Monocotylidae) plus Udonella caligorum (Udonellidae). Trees were constructed using maximum likelihood, minimum evolution and maximum parsimony algorithms. An initial tree, generated from sequences 315 bases long, suggests that Capsalinae, Encotyllabinae, Entobdellinae and Trochopodinae are monophyletic, but that Benedeniinae is paraphyletic. Analyses indicate that Neobenedenia, currently in the Benedeniinae, should perhaps be placed in a separate subfamily. An additional analysis was made which omitted 3 capsalid taxa (for which only short sequences were available) and all outgroup taxa because of alignment difficulties. Sequence length increased to 693 bases and good branch support was achieved. The Benedeniinae was again paraphyletic. Higher-level classification of the Capsalidae, evolution of the Entobdellinae and issues of species identity in Neobenedenia are discussed.I. D. Whittington, M. R. Deveney, J. A. T. Morgan, L. A. Chisholm and R. D. Adlar

Metodología probabilística para la segmentación de estructuras cerebrales basada en procesos Gaussianos

Con el desarrollo de este proyecto de investigación, se busca avanzar en el estudio de los métodos para la segmentación de formas 3D relacionadas a estructuras cerebrales utilizando modelos probabilísticos de variables latentes, los cuales a partir de un conocimiento a-priori de las estructuras 3D permitan contemplar determinados descriptores y así encontrar nuevas posibles deformaciones sintéticas de la estructura que permitan al modelo mayor flexibilidad y especificidad para capturar las variaciones de una estructura dada. Esto, con el fin de darle más robustez al desarrollo de sistemas de apoyo al especialista para la identificación de estructuras cerebrales en un determinado procedimiento de cirugía guiada por imagen y brindar un apoyo al especialista a la hora de dar un diagnostico..

On the Localization of One-Photon States

Single photon states with arbitrarily fast asymptotic power-law fall-off of energy density and photodetection rate are explicitly constructed. This goes beyond the recently discovered tenth power-law of the Hellwarth-Nouchi photon which itself superseded the long-standing seventh power-law of the Amrein photon.Comment: 7 pages, tex, no figure

Metal chaperones prevent zinc-mediated cognitive decline

© 2014 Elsevier Inc. Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availability of zinc at the glutamatergic synapse. ZnT3 has been shown to decline with age and in Alzheimer's disease (AD) and is crucially involved in learning and memory. In this study, we utilised whole animal behavioural analyses in the ZnT3 KO mouse line, together with electrophysiological analysis of long-term potentiation in brain slices from ZnT3 KO mice, to show that metal chaperones (clioquinol, 30 mg/kg/day for 6 weeks) can prevent the age-dependent cognitive phenotype that characterises these animals. This likely occurs as a result of a homeostatic restoration of synaptic protein expression, as clioquinol significantly restored levels of various pre- and postsynaptic proteins that are critical for normal cognition, including PSD-95; AMPAR and NMDAR2b. We hypothesised that this clioquinol-mediated restoration of synaptic health resulted from a selective increase in synaptic zinc content within the hippocampus. While we demonstrated a small regional increase in hippocampal zinc content using synchrotron x-ray fluorescence microscopy, further sub-region analyses are required to determine whether this effect is seen in other regions of the hippocampal formation that are more closely linked to the synaptic plasticity effects observed in this study. These data support our recent report on the use of a different metal chaperone (PBT2) to prevent normal age-related cognitive decline and demonstrate that metal chaperones are efficacious in preventing the zinc-mediated cognitive decline that characterises ageing and disease