Philosophy of contemporary educational management

This article deals with the evolving philosophy of contemporary educational management, elucidating the underlying principles and paradigms that guide the administration of educational institutions in the 21st century. In an era marked by rapid technological advancements, globalization, and shifting educational paradigms, the philosophy of educational management plays a pivotal role in shaping the quality and effectiveness of educational systems worldwide. This article explores the key philosophical foundations that underpin modern educational management, including a focus on student-centered approaches, a commitment to diversity and inclusion, a dedication to lifelong learning, and an embrace of data-driven decision-making. Additionally, it investigates the dynamic interplay between traditional educational management models and innovative approaches such as online education, flipped classrooms, and personalized learning. Through a comprehensive review of contemporary literature and case studies, this article offers insights into the challenges and opportunities facing educational leaders in their quest to provide equitable, effective, and future-ready educational experiences. Ultimately, it underscores the need for educational management philosophy to continually adapt and evolve to meet the ever-changing demands of the educational landscape

Investigation of Solar Flare Classification to Identify Optimal Performance

When an intense brightness for a small amount of time is seen in the sun, then we can say that a solar flare emerged. As solar flares are made up of high energy photons and particles, thus causing the production of high electric fields and currents and therefore results in the disruption in space-borne or ground-based technological system. It also becomes a challenging task to extract its important features for prediction. Convolutional Neural Networks have gain a significant amount of popularity in the classification and localization tasks. This paper has given stress on the classification of the solar flares emerged on different years by stacking different convolutional layers followed by max pooling layers. From the reference of Alexnet, the pooling layer employed in this paper is the overlapping pooling. Also two different activation functions that are ELU and CReLU have been used to investigate how many number of convolutional layers with a particular activation function provides with the best results on this dataset as the size of the dataset in this domain is always small. The proposed investigation can be further used in a novel solar prediction systems

Who can help me?\u27\u27: Knowledge Infused Matching of Support Seekers and Support Providers during COVID-19 on Reddit

During the ongoing COVID-19 crisis, subreddits on Reddit, such as r/Coronavirus saw a rapid growth in user\u27s requests for help (support seekers - SSs) including individuals with varying professions and experiences with diverse perspectives on care (support providers - SPs). Currently, knowledgeable human moderators match an SS with a user with relevant experience, i.e, an SP on these subreddits. This unscalable process defers timely care. We present a medical knowledge-infused approach to efficient matching of SS and SPs validated by experts for the users affected by anxiety and depression, in the context of with COVID-19. After matching, each SP to an SS labeled as either supportive, informative, or similar (sharing experiences) using the principles of natural language inference. Evaluation by 21 domain experts indicates the efficacy of incorporated knowledge and shows the efficacy the matching system

Theoretical aspects about bright future of polymer nano-composites in mechanical engineering

Abstract: In mechanical terms, nanocomposites differ from conventional composite materials due to the exceptionally high surface to volume ratio of the reinforcing phase and/or its exceptionally high aspect ratio. The reinforcing material can be made up of particles (e.g. minerals), sheets (e.g. exfoliated clay stacks) or fibres (e.g. carbon nanotubes or electrospun fibres). The area of the interface between the matrix and reinforcement phase(s) is typically an order of magnitude greater than for conventional composite materials. The matrix material properties are significantly affected in the vicinity of the reinforcement

Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling

Background: Tamoxifen (TAM) is widely used in the chemotherapy of breast cancer and as a preventive agent against recurrence after surgery. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy. Celecoxib (CXB), a selective COX-2 inhibitor, suppresses VEGF gene expression by targeting the VEGF promoter responsible for its inhibitory effect. For this study, we had selected CXB as non-steroidal anti-inflammatory drug in combination with TAM for suppressing VEGF expression and simultaneously reducing doses of both the drugs. Methods: The effects of CXB combined with TAM were examined in two human breast cancer cell lines in culture, MCF7 and MDA-MB-231. Assays of proliferation, apoptosis, angiogenesis, metastasis, cell cycle distribution and receptor signaling were performed. Results: Here, we elucidated how the combination of TAM and CXB at nontoxic doses exerts anti-angiogenic effects by specifically targeting VEGF/VEGFR2 autocrine signaling through ROS generation. At the molecular level, TAM-CXB suppresses VHL-mediated HIF-1α activation, responsible for expression of COX-2, MMP-2 and VEGF. Besides low VEGF levels, TAM-CXB also suppresses VEGFR2 expression, confirmed through quantifying secreted VEGF levels, luciferase and RT-PCR studies. Interestingly, we observed that TAM-CXB was effective in blocking VEGFR2 promoter induced expression and further 2 fold decrease in VEGF levels was observed in combination than TAM alone in both cell lines. Secondly, TAM-CXB regulated VEGFR2 inhibits Src expression, responsible for tumor progression and metastasis. FACS and in vivo enzymatic studies showed significant increase in the reactive oxygen species upon TAM-CXB treatment. Conclusions: Taken together, our experimental results indicate that this additive combination shows promising outcome in anti-metastatic and apoptotic studies. In a line, our preclinical studies evidenced that this additive combination of TAM and CXB is a potential drug candidate for treatment of breast tumors expressing high levels of VEGF and VEGFR2. This ingenious combination might be a better tailored clinical regimen than TAM alone for breast cancer treatment

Interplay of spherical closed shells and N/Z asymmetry in quasifission dynamics

Background: Quasifission (QF) has gained tremendous importance in heavy-ion nuclear physics research because of its strong influence on superheavy-element synthesis. Collisions involving closed-shell nuclei in the entrance channel are found to affect the QF reaction mechanism. Hence, it is important to improve the understanding of their effect on QF. Apart from that, some recent studies show that the difference in N/Z of reaction partners influences the reaction dynamics. Since heavier doubly magic nuclei have different N/Z than lighter doubly magic nuclei, it is important to understand the effect of N/Z mismatch as well as the effect of shell closures.The authors acknowledge the Australian Research Council for support through Discovery Grants No. DP140101337, No. DP160101254, No. FL110100098, No. DE140100784, No. FT120100760, and No. DP170102318