Data on Nitrate–Nitrite pollution in the groundwater resources a Sonqor plain in Iran

Nitrate is a groundwater pollutant which in higher concentrations limits, leads to health hazard such as Methemoglobinemia and formation of nitrosamine compounds. In this research, the nitrate and nitrite concentrations in all water resources in the villages of Songor plain were determined and the relationship between these values with the water table and zonation of nitrate concentration were investigated in the GIS environment. In this study, 37 samples of all groundwater resources of Sonqor plain were taken in, high water (March 2016) and low water (October 2017) periods. Water nitrate levels were then determined by spectrophotometry and results compared with national standards of Iran and analyzed by SPSS. Finally, the concentration distribution mapping was carried out in GIS environment and the factors affecting nitrite changes were analyzed. Nitrate concentration of water resources of Sonqor plain was fluctuating at 3.09–88.5 mg per Liter. In one station, nitrite concentrations in the high (88.5 mg/L) and low (71.4 mg/L) water seasons were higher than the maximum limit. Low thickness of alluvium, the site of wells in the downstream farmlands, the farming situation of the region, nitrate leaching from agricultural soils and wide use of nitrogen fertilizers in agriculture were considered as the causes of the pollution in one station. Though the average concentration of nitrate and nitrite are not high in this region, but because of problematic consequences of high nitrate concentrations to human health, proper management in use of chemical fertilizers, treatment or disposal of contaminated wells and protection of water wells is highly recommended

Correction to: Ecological modeling and distribution analysis of digger scorpions: Odontobuthus doriae, Odontobuthus bidentatus (Scorpiones: Buthidae) and Scorpio maurus (Scorpiones: Scorpionidae) in Iran using the maximum entropy method (Applied Entomology and Zoology, (2020), 55, 1, (17-24), 10.1007/s13355-019-00647-9)

The word �Odonthubutus� should be replaced with �Odontobuthus� throughout the article. © 2020, The Japanese Society of Applied Entomology and Zoology

Nambu monopoles in lattice Electroweak theory

We considered the lattice electroweak theory at realistic values of $\alpha$ and $\theta_W$ and for large values of the Higgs mass. We investigated numerically the properties of topological objects that are identified with quantum Nambu monopoles. We have found that the action density near the Nambu monopole worldlines exceeds the density averaged over the lattice in the physical region of the phase diagram. Moreover, their percolation probability is found to be an order parameter for the transition between the symmetric and the broken phases. Therefore, these monopoles indeed appear as real physical objects. However, we have found that their density on the lattice increases with increasing ultraviolet cutoff. Thus we conclude, that the conventional lattice electroweak theory is not able to predict the density of Nambu monopoles. This means that the description of Nambu monopole physics based on the lattice Weinberg - Salam model with finite ultraviolet cutoff is incomplete. We expect that the correct description may be obtained only within the lattice theory that involves the description of TeV - scale physics.Comment: LATE

Systematic review of pre-clinical and clinical devices for magnetic resonance-guided radiofrequency hyperthermia

Clinical trials have demonstrated the therapeutic benefits of adding radiofrequency (RF) hyperthermia (HT) as an adjuvant to radio- and chemotherapy. However, maximum utilization of these benefits is hampered by the current inability to maintain the temperature within the desired range. RF HT treatment quality is usually monitored by invasive temperature sensors, which provide limited data sampling and are prone to infection risks. Magnetic resonance (MR) temperature imaging has been developed to overcome these hurdles by allowing noninvasive 3D temperature monitoring in the target and normal tissues. To exploit this feature, several approaches for inserting the RF heating devices into the MR scanner have been proposed over the years. In this review, we summarize the status quo in MR-guided RF HT devices and analyze trends in these hybrid hardware configurations. In addition, we discuss the various approaches, extract best practices and identify gaps regarding the experimental validation procedures for MR - RF HT, aimed at converging to a common standard in this process

Baryogenesis in Cosmological Model with Superstring-Inspired E_6 Unification

We have developed a concept of parallel existence of the ordinary (O) and hidden (H) worlds with a superstring-inspired E_6 unification, broken at the early stage of the Universe into SO(10) X U(1) - in the O-world, and SU(6)' X SU(2)' - in the H-world. As a result, we have obtained in the hidden world the low energy symmetry group G'_SM X SU(2)'_\theta, instead of the Standard Model group G_SM. The additional non-Abelian SU(2)'_\theta group with massless gauge fields, "thetons", is responsible for the dark energy. We present a baryogenesis mechanism with the B-L asymmetry produced by the conversion of ordinary leptons into particles of the hidden sector.Comment: 15 pages, 2 figure

Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody

The development of increasingly complex antibody formats, such as bispecifics, can lead to the formation of increasingly complex high- and low-molecular-weight by-products. Here, we focus on the characterization of high molecular weight species (HMWs) representing the highest complexity of size variants. Standard methods used for product release, such as size exclusion chromatography (SEC), can separate HMW by-products from the main product, but cannot distinguish smaller changes in mass. Here, for the identification of the diverse and complex HMW variants of a trivalent bispecific CrossMAb antibody, offline fractionation, as well as production of HMW by-products combined with comprehensive analytical testing, was applied. Furthermore, HMW variants were analyzed regarding their chemical binding nature and tested in functional assays regarding changes in potency of the variants. Changes in potency were explained by detailed characterization using mass photometry, SDS-PAGE analysis, native mass spectrometry (MS) coupled to SEC and bottom-up proteomics. We identified a major portion of the HMW by-products to be non-covalently linked, leading to dissociation and changes in activity. We also identified and localized high heterogeneity of a by-product of concern and applied a CD3 affinity column coupled to native MS to annotate unexpected by-products. We present here a multi-method approach for the characterization of complex HMW by-products. A better understanding of these by-products is beneficial to guide analytical method development and proper specification setting for therapeutic bispecific antibodies to ensure constant efficacy and patient safety of the product through the assessment of by-products

The Supersymmetric Standard Models with Decay and Stable Dark Matters

We propose two supersymmetric Standard Models (SMs) with decaying and stable dark matter (DM) particles. To explain the SM fermion masses and mixings and have a heavy decay DM particle S, we consider the Froggatt-Nielsen mechanism by introducing an anomalous U(1)_X gauge symmetry. Around the string scale, the U(1)_X gauge symmetry is broken down to a Z_2 symmetry under which S is odd while all the SM particles are even. S obtains a vacuum expectation value around the TeV scale, and then it can three-body decay dominantly to the second/third family of the SM leptons in Model I and to the first family of the SM leptons in Model II. Choosing a benchmark point in the constrained minimal supersymmetric SM with exact R parity, we show that the lightest neutralino DM is consistent with the CDMS II experiment. Considering S three-body decay and choosing suitable parameters, we show that the PAMELA and Fermi-LAT experiments and the PAMELA and ATIC experiments can be explained in Model I and Model II, respectively.Comment: RevTex4, 26 pages, 6 figures, references added, version to appear in EPJ

Enhancement of dark matter relic density from the late time dark matter conversions

We demonstrate that if the dark matter (DM) in the Universe contains multiple components,the interactions between the DM components may induce DM conversions. It is then possible that the lightest DM component with an annihilation cross section much larger than that of the typical weakly interacting massive particle (WIMP) can obtain a relic density in consistent with the cosmological observations, due to an enhancement from the DM conversion process at late time after the thermal decoupling. This provides an alternative source of large boost factor required to explain the excesses reported by the recent DM indirect search experiments.Comment: 15 pages, 3 figures, version to appear in Eur.Phys.J.