110 GHz rapid, continous tuning from an optical parametric oscillator pumped by a fiber-amplified DBR diode laser

A singly-resonant continuous-wave optical parametric oscillator (cw-OPO) pumped by a fiber-amplified diode laser is described. Tuning of the pump source allowed the OPO output to be tuned continuously, without mode-hops, over 110 GHz in 29 ms. Discontinuous pump tuning over 20 nm in the region of 3.4 µm was also obtained. The rapid and continuous idler tuning was demonstrated by the measurement of a methane absorption spectrum. We believe this to be the first example of a singly-resonant OPO pumped by a fiber-amplified diode laser and the mode-hop free tuning range to be the highest reported for a cw-OPO

Mid-infrared wavelength- and frequency-modulation spectroscopy with a pump-modulated singly-resonant optical parametric oscillator

We describe the implementation of the wavelength- and frequency-modulation spectroscopy techniques using a singly-resonant optical parametric oscillator (OPO) pumped by a fiber-amplified diode laser. Frequency modulation of the diode laser was transferred to the OPO¿s mid-infrared idler output, avoiding the need for external modulation devices. This approach thus provides a means of implementing these important techniques with powerful, widely tunable, mid-infrared sources while retaining the simple, flexible modulation properties of diode lasers

Cefixime and ornidazole combination induced fixed drug eruption: a case report

Cefixime, a third generation cephalosporin and ornidazole, a nitroimidazole is used for a wide variety of conditions like urinary tract infections, otitis media, pharyngitis, uncomplicated gonorrhea and anaerobic infections. Fixed drug eruption (FDE) is commonly associated with anticonvulsants, antimicrobials and NSAIDs. Here we report a case of a rare cefixime and ornidazole combination induced fixed drug eruption. A 39 year old male developed hyper-pigmented patches over both forearms and left thigh after consuming fixed dose combination of cefixime and ornidazole tablet for the treatment of urinary tract infection

Mid-IR continuous-wave fiber-laser-pumped optical parametric oscillators

We review recent developments in continuous-wave mid-infrared optical parametric oscillators pumped by fiber lasers. Such devices are potentially valuable spectroscopic sources providing high output powers and rapid, wide-range tuning in the mid-infrared molecular fingerprint region

Incoherently pumped continuous wave optical parametric oscillator broadened by non-collinear phasematching

In this paper, we report on a singly resonant optical parametric oscillator (OPO) pumped by an amplified spontaneous emission (ASE) source. The pump focusing conditions allow non-collinear phasematching, which resulted in a 230 nm (190 cm$^{-1}$) spectral bandwidth. Calculations indicate that such phasematching schemes may be used to further broaden OPO spectral bandwidths.Comment: 7 pages 4 figure

Genetic variation of morphological and yield-related traits in backcrossed and selfed population of maize

The number of genes controlling the morphological and yield-related traits and their mode of action plays a vital role in selecting traits and favourable progenies in a segregating population. In this study, we analysed the skewness and kurtosis in the backcrossed and selfed populations of SC11-2×UMI1230β1+. Negative skewness refers to redundant gene activity, positive skewness is connected to complementary gene action. Positive kurtosis suggests the existence of gene activity controlled by a smaller number of genes. Negative kurtosis shows a lack of gene activity and is controlled by a large number of genes. The BC2F2 population of plant height and single plant yield showed positive skewness and platykurtic distribution, suggesting that the genes were governed by complementary gene action and controlled by the large number of genes. This implied need for rigorous selection to achieve a genetic gain in later generations. Cob length and kernel weight showed a duplicate gene action which implied that mild selection can fix these traits and accelerate genetic gain

GC-MS-based metabolomics analysis unravels the therapeutic potential of Neolamarckia cadamba fruit peel

Kadam (Neolamarckia cadamba (Roxb.) is an evergreen tropical tree widely grown in Asia, particularly in India. Neolamarckia cadamba commonly known as kadam, cadamba or burflower tree. The roots, leaves, barks, and fruits of N. cadamba possess medicinal properties and are commonly used in the pharmaceutical industry. Fruit peels are the main waste and may contain various biologically active compounds. However, no prior knowledge about the therapeutic compounds of the peel. The objective of the present study was to unveil therapeutic compounds from the peel by Gas Chromatography–Mass Spectrometry (GC-MS) based metabolomics analysis. Metabolites from the kadam fruit peel were isolated and derivatized using MSTFA, characterized by the GC-MS analysis. Raw spectral data were pre-processed, and peak identification was performed using SHIMADZU Postrun analyse software. The metabolites in N. cadamba fruit peel were identified by comparing the peaks with the mass spectral reference database NIST v20. The results showed that the peel of kadam fruit contains 149 metabolites, which were further categorized into 46 different metabolite classes, with 52 different metabolic pathways and 63 biological functions. The principal roles of the metabolites were identified by functional annotation and enrichment analysis. It revealed that metabolites were responsible for anti-inflammation, anti-oxidant, anti-microbial, and anti-cancer properties. In summary, the peel of kadam fruit also contains various therapeutic compounds like other cadamba parts (i.e., roots, leaves, barks, and fruits). Further, comparing the peel with other parts discloses the peel-specific metabolites. The results obtained in this study could be useful for the pharmaceutical industry

The 5-HTTLPR variant in the serotonin transporter gene modifies degeneration of brain regions important for emotion in behavioral variant frontotemporal dementia

AbstractThe serotonin transporter length polymorphism (5-HTTLPR) short allele (5-HTTLPR-s) has been associated with differential susceptibility for anxiety and depression in multiple psychiatric disorders. 5-HTTLPR-s modifies the serotonergic systems that support emotion and behavioral regulation by reducing gene expression, which slows the reuptake of serotonin, and is associated with distinct morphological and functional effects. Serotonergic systems are also shown to be dysfunctional in behavioral variant frontotemporal dementia (bvFTD), a disease characterized by marked socioemotional dysfunction. However, studies of 5-HTTLPR-s effects in bvFTD have been inconsistent. Our objective was to investigate the patterns of gray matter volume by 5-HTTLPR-s genotype in both healthy older controls and bvFTD patients. We performed voxel-based morphometry of 179 cognitively normal older adults and 24 bvFTD cases to determine brain changes associated with dose (0/1/2) of 5-HTTLPR-s allele. 5-HTTLPR-s frequency did not differ between controls and bvFTD. We found a significant interaction effect whereby carrying more 5-HTTLPR-s alleles in bvFTD was associated with smaller volume in left inferior frontal gyrus (T = 4.86, PFWE = 0.03) and larger volume in right temporal lobe (T = 5.01, PFWE = 0.01). These results suggest that the 5-HTTLPR-s allele differentially influences brain morphology in bvFTD. We propose that patients with bvFTD and 5-HTTLPR-s have altered volumes in regions that support socioemotional behavior, which may be a developmental or disease-related compensation for altered serotonergic activity