10 research outputs found
Varying R<sup>2</sup> and P<sub>SNP</sub> cutoffs for the ADRA1 Pathway.
<p>Varying R<sup>2</sup> and P<sub>SNP</sub> cutoffs for the ADRA1 Pathway.</p
Descriptive characteristics of phenotypes among study participants.
<p>Values are expressed as mean±SD.</p
ADRA1 pathway associated genes. Gene names are in italics.
<p>Regulators are in circles. TH, tyrosine hydroxylase; DDC, dopa decarboxylase; DBH, dopamine beta hydroxylase; PNMT, phenylethanolamine N-methyltransferase; ADRA1A, ADRA1B, ADRA1D, adrenergic alpha 1 receptors; GNAQ, guanine nucleotide binding protein, Q; GNA11, guanine nucleotide binding protein, alpha 11; PLCB3, phospholipase C, beta 3; ITPR1, inositol 1,4,5-triphosphate receptor, type 1; POMC, proopiomelanocortin; COMT, catechol-o-methyltransferase; MAO, monoamine oxidase; RGS 2,4,5, regulator of g-protein signaling.</p
Pathway Association Results.
*<p>p-value is significant after correction for multiple testing.</p>†<p>ADRA1, -receptors is the same pathway as ADRA1, with the ADRA1 receptor genes removed from the model.</p><p>Adjustment was made for sex, age, age<sup>2</sup> and BMI for all models.</p
Line graphs representing the ADRA1 pathway genetic risk model for DBP, SBP, and hypertension (HTN).
<p>The risk score was divided into quintiles, with the reference category being the lowest risk score quintile. * P<0.05. ** P<0.005. ***P<0.0001.</p
MOESM2 of Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors
Additional file 2. Tables showing comparisons of subjects with and without Brian MRI and pre-stroke cognitive decline
MOESM1 of Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors
Additional file 1. Further details on the Cognitive Assessment Battery
STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease
Peer reviewe
Novel and previously identified BMI and WHR<sub>adjBMI</sub> loci at <i>P</i> < 5×10<sup>−8</sup> in African ancestry discovery and replication samples, and European ancestry replication samples.
<p>Novel and previously identified BMI and WHR<sub>adjBMI</sub> loci at <i>P</i> < 5×10<sup>−8</sup> in African ancestry discovery and replication samples, and European ancestry replication samples.</p
Additional novel BMI and WHR<sub>adjBMI</sub> loci at <i>P</i> < 5×10<sup>−8</sup> in sex-stratified analyses of African ancestry discovery and replication samples.
<p>Additional novel BMI and WHR<sub>adjBMI</sub> loci at <i>P</i> < 5×10<sup>−8</sup> in sex-stratified analyses of African ancestry discovery and replication samples.</p