Response of rate-and-state seismogenic faults to harmonic shear-stress perturbations

Field and laboratory observations show that seismicity has non-trivial period-dependent response to periodic stress perturbations. In Nepal, seismicity shows significant variations in response to annual monsoon-induced stress variations but not to semidiurnal tidal stresses of the same magnitude. Such period dependence cannot be explained by the Coulomb failure model and spring-slider rate-and-state model (SRM). Here, we study seismicity response to periodic stress perturbations in a 2-D continuum model of a rate-and-state fault (that is, a finite rate-and-state fault). We find that the resulting seismicity indeed exhibits nearly periodic variations. Their amplitude is maximum at a certain period, T_a, and decreases with smaller and larger periods to the SRM predictions, remaining much larger than the SRM predictions for a wide range of periods around T_a. We attribute the higher sensitivity of finite faults to their finite nucleation zones which vary in space and have a different slip-velocity evolution than that of the SRM. At periods T ≫ T_a and T ≪ T_a, the seismicity-rate variations are in phase with the stress-rate and stress variations, respectively, consistent with the SRM, although a gradual phase shift appears as T increases towards T_a. Based on the similarities with the SRM and our simulations, we propose a semi-analytical expression for T_a. Plausible sets of model parameters make T_a equal to 1 yr, potentially explaining Nepal observations and constraining the fault properties. Our finite-fault findings indicate that aσ, where a is a rate-and-state parameter and σ is the effective normal stress, can be severely underestimated based on the SRM

Search for Flavoured Multiquarks in a Simple Bag Model

We use a bag model to study flavoured mesonic $(Qq\bar q\bar q)$ and baryonic $({\overline Q}qqqq)$ states, where one heavy quark $Q$ is associated with light quarks or antiquarks, and search for possible stable multiquarks. No bound state is found. However some states lie not too high above their dissociation threshold, suggesting the possibility of resonances, or perhaps bound states in improved models.Comment: REVTEX, VERSION 3.

Weakly-Bound Three-Body Systems with No Bound Subsystems

We investigate the domain of coupling constants which achieve binding for a 3-body system, while none of the 2-body subsystems is bound. We derive some general properties of the shape of the domain, and rigorous upper bounds on its size, using a Hall--Post decomposition of the Hamiltonian. Numerical illustrations are provided in the case of a Yukawa potential, using a simple variational method.Comment: gzipped ps with 11 figures included. To appear in Phys. Rev.

Invasive pulmonary aspergillosis in patients with decompensated cirrhosis: case series

BACKGROUND: Opportunistic invasive fungal infections are increasingly frequent in intensive care patients. Their clinical spectrum goes beyond the patients with malignancies, and for example invasive pulmonary aspergillosis has recently been described in critically ill patients without such condition. Liver failure has been suspected to be a risk factor for aspergillosis. CASE PRESENTATION: We describe three cases of adult respiratory distress syndrome with sepsis, shock and multiple organ failure in patients with severe liver failure among whom two had positive Aspergillus antigenemia and one had a positive Aspergillus serology. In all cases bronchoalveolar lavage fluid was positive for Aspergillus fumigatus. Outcome was fatal in all cases despite treatment with voriconazole and agressive symptomatic treatment. CONCLUSION: Invasive aspergillosis should be among rapidly raised hypothesis in cirrhotic patients developing acute respiratory symptoms and alveolar opacities

The Effects of Breeding Protocol in C57BL/6J Mice on Adult Offspring Behaviour

Animal experiments have demonstrated that a wide range of prenatal exposures can impact on the behaviour of the offspring. However, there is a lack of evidence as to whether the duration of sire exposure could affect such outcomes. We compared two widely used methods for breeding offspring for behavioural studies. The first involved housing male and female C57Bl/6J mice together for a period of time (usually 10–12 days) and checking for pregnancy by the presence of a distended abdomen (Pair-housed; PH). The second involved daily introduction of female breeders to the male homecage followed by daily checks for pregnancy by the presence of vaginal plugs (Time-mated; TM). Male and female offspring were tested at 10 weeks of age on a behavioural test battery including the elevated plus-maze, hole board, light/dark emergence, forced swim test, novelty-suppressed feeding, active avoidance and extinction, tests for nociception and for prepulse inhibition (PPI) of the acoustic startle response. We found that length of sire exposure (LSE) had no significant effects on offspring behaviour, suggesting that the two breeding protocols do not differentially affect the behavioural outcomes of interest. The absence of LSE effects on the selected variables examined does not detract from the relevance of this study. Information regarding the potential influences of breeding protocol is not only absent from the literature, but also likely to be of particular interest to researchers studying the influence of prenatal manipulations on adult behaviour

Microbiome to Brain:Unravelling the Multidirectional Axes of Communication

The gut microbiome plays a crucial role in host physiology. Disruption of its community structure and function can have wide-ranging effects making it critical to understand exactly how the interactive dialogue between the host and its microbiota is regulated to maintain homeostasis. An array of multidirectional signalling molecules is clearly involved in the host-microbiome communication. This interactive signalling not only impacts the gastrointestinal tract, where the majority of microbiota resides, but also extends to affect other host systems including the brain and liver as well as the microbiome itself. Understanding the mechanistic principles of this inter-kingdom signalling is fundamental to unravelling how our supraorganism function to maintain wellbeing, subsequently opening up new avenues for microbiome manipulation to favour desirable mental health outcome

If...

“If you can keep your head when all about you Are losing theirs and blaming it on you; If you can trust yourself when all men doubt you, But make allowance for their doubting too: If you can wait and not be tired by waiting, Or being lied about, don’t deal in lies, Or being hated don’t give way to hating, And yet don’t look too good, nor talk too wise; If you can dream — and not make dreams your master; If you can think — and not make thoughts your aim, If you can meet with Triumph and Disaster And treat those two impostors just the same: If you can bear to hear the truth you’ve spoken Twisted by knaves to make a trap for fools, Or watch the things you gave your life to, broken