Bright and Dark Soliton Solutions of the (2 + 1)-Dimensional Evolution Equations

In this paper, we obtained the 1-soliton solutions of the (2+1)-dimensional Boussinesq equation and the Camassa–Holm–KP equation. By using a solitary wave ansatz in the form of sechp function, we obtain exact bright soliton solutions and another wave ansatz in the form of tanhp function we obtain exact dark soliton solutions for these equations. The physical parameters in the soliton solutions are obtained nonlinear equations with constant coefficients

Giresun Tombul Fındık (Corylus avellana L.) Yağının Serviks, Meme ve Kolon Kanser Hücrelerinde Sitotoksik ve Antianjiyojenik Aktivitesi

Corylus avellana L. çoğunlukla Giresun’da yetişen dünyanın en kaliteli fındık türlerinden biridir. Bu çalışma, Giresun Tombul fındık yağının (0.5, 5 ve 50 mg L-1) antikanser ve antianjiyojenik aktivitelerini değerlendirmek amacıyla gerçekleştirilmiştir. Sitotoksisite insan serviks, kolon ve meme kanseri hücreleri üzerinde MTT ve laktat dehidrojenaz salım (LDH) analizleri ile belirlenmiştir. Hücrelerin oksidatif durumu, toplam oksidatif stres (TOS) ve toplam antioksidan kapasite (TAK) yöntemleriyle ortaya konulmuştur. Anti-anjiyojenik aktiviteyi değerlendirmek için civciv koryoallantoik membran (HET-CAM) deneyi kullanılmıştır. Sonuçlarımız, C. avellana yağının özellikle serviks kanseri hücrelerinde daha fazla olmak üzere, serviks ve kolon kanseri hücrelerinin (sırasıyla IC 50 = 6.5 ± 0.35 mg L-1 ve IC 50 = 26.2 ± 3.15 mg L-1) canlılığını önemli ölçüde inhibe ettiğini göstermiştir. Bununla birlikte, fındık yağ örneği, LDH salınımında önemli bir inhibisyona yol açarak sitotoksisite ile doğrusal bir korelasyon sergilemiştir. C. avellana yağ örneği konsantrasyona bağlı bir şekilde serviks ve kolon hücrelerinin TAK seviyelerinde önemli bir artışa neden olurken, TOS seviyelerinde istatistiksel olarak önemli azalmaya yol açmıştır. Aynı zamanda, C. avellana yağ örneği yüksek konsantrasyonlarda anti-anjiyojenik etkinlik göstermiştir. Sonuçlar, Giresun fındığının umut verici bir antikanser ajan olduğunu ve bununla birlikte terapötik etkinliğini ortaya koymak için daha ileri çalışmalara ihtiyaç olduğunu göstermiştir

The In Vitro Effects of Dermotocarpon Intestiniforme (A Lichen) Extracts Against Cadmium Induced Genetic and Oxidative Damage

WOS: 000311128800005Cadmium (Cd) is one of the most harmful heavy metals and influences important metabolic processes causing serious damages in many organs. It is well known that Cd could provoke generation of reactive oxygen species (ROS) and DNA damage. Some antioxidants (such as vitamin C, vitamin E and N-acetyl-L-cysteine) have been used as protectors against cadmium-induced toxicity. On the other hand, lichens have long been investigated for biological activities; mainly antimicrobial and antioxidant activities. In this study, we aimed to determine whether D. intestiniforme aqueous extracts (25 and 50 ppm) conferred a protection against cadmium chloride (CdCl2) (30 ppm) induced genetic and oxidative damage in human whole blood cultures. Biochemical parameters (total antioxidant capacity [TAC] and total oxidative status [TOS]) were examined to determine oxidative effects. The micronucleus (MN) test was used for analysing genotoxic influences. In addition nucleer division indeks (NDI) was used to determine cytotoxicty. Oxidative damage by CdCl2 in erythrocytes decreased with application of lichen extracts. Similarly, the positive effect of lichen aqueous extracts in decreasing the incidence of MN in comparison with an unprotected level was attained when cultures were treated simultaneously with CdCl2 and the extracts (P<0.05). The findings of this study firstly revealed that D. intestiniforme modulated Cd-induced genetic and oxidative damage in human blood cultures due to its antioxidant and/or detoxifying nature

Weight Loss Experiences Of Obese Individuals; Qualitative Study

Objective: Obesity is a leading preventable cause of death worldwide. Being overweight or obese has a serious impact on health. Treatment of obesity needs a comprehensive approach. Biopsychosocial approach of family physicians is invaluable in obesity management. In this study, we aimed to evaluate experiences of obese individuals during their weight-losing attempts and to explore the factors affecting success and failure of different approaches. Methods: We conducted indepth, semi-structured, face to face interviews with 30 participants whose Body Mass Index was higher than 30). Interviews were audio-recorded and transcribed, and qualitatively analysed using a thematic framework method. Results: 26 women and 4 men have accepted to join our study. Analysis of in depth interviews emerged 5 major themes which were: the different perception of obesity among individuals; awareness of obesity; loss of self-confidence; belief in treatment and effects on quality of life. Conclusions: Each patient has a different need and different expectation while controlling weight. As a part of biopsychosocial approach the family physician needs to understand the factors that bring the patient to current condition and see which approach would be the best for individual patient for weight management.Wo

Anticancer and antiangiogenesis activities of novel synthesized 2-substituted benzimidazoles molecules

AKKAN, TAMER/0000-0002-9866-4475WOS: 000489111500005In this study, novel 2-substituted benzimidazoles molecules having triazole, thiadiazole, and oxadiazole rings were synthesized and were evaluated by anticancer, antioxidant/oxidant status, genotoxicity, and antiangiogenesis assays. Anticancer activity of the compounds was determined by MTT (0.5, 5, and 50 mu g/mL) and lactate dehydrogenase (LDH) release assays against human prostate and breast cancer cells. Oxidative status of cells was elicited by total oxidative stress and total antioxidant capacity methods. Chick chorioallantoic membrane assay was used to evaluate the antiangiogenic activity. Genotoxicity was evaluated by the sister chromatid exchange (SCE) and micronucleus (MN) tests in lymphocyte cultured human blood. Our results showed that some of the compounds synthesized had significant antiproliferative activity against both cancer cell lines (between 4.54 +/- 0.35 and 20.17 +/- 3.15 mu g/mL), with higher inhibition of the breast cancer, and caused inhibition of LDH release with a linear correlation to MTT results. Moreover, the 5 mu g/mL dose of these molecules led to an increase in antioxidant levels. Compounds had antiangiogenic effectiveness in a dose-dependent manner. Additionally, all of the compounds did not affect SCE and MN levels compared to controls. In conclusion, these newly synthesized molecules can be a resource of new anticancer agents with their nongenotoxic, antiproliferative, and antiangiogenic properties

Apoptosis-inducing activities of Halopteris scoparia L. Sauvageau (Brown algae) on cancer cells and its biosafety and antioxidant properties

WOS: 000470132100002PubMed ID: 30969390The aim of this study was to reveal the biological activities and in vivo toxicity profiles of n-hexane, chloroform and methanol extracts of brown algae Halopteris scoparia L. Sauvageau. In this study, extracts were tested for their phytochemical contents and antioxidant activities. The cytotoxic activities of the extracts against cervical adenocarcinoma (HeLa), colon colorectal adenocarcinoma (CaCo-2) and breast adenocarcinoma (MCF7) cells were assessed by MTT assay and total RNAs derived from cell lines to analyze gene expression were analyzed by Real Time Ready Human Apoptosis Panel 96. Also, in vivo toxicity and irritation effects of extracts were evaluated by LD50 acute toxicity test and Hen's egg test chorioallantoic membrane (HET-CAM) assay, respectively. Our results showed that the phenolic and flavonoid contents were determined only in methanol extract (33.20 +/- 1.41mg GAE/g and 1.26 +/- 0.95mg QE/g). Also, n-hexane has a broader spectrum of content than methanol and chloroform extracts. Furthermore, n-hexane extract in DPPH and methanol extract in ABTS(+) exhibited the best antioxidant activity. In addition, MTT results revealed that each three extracts cause a significant reduction in cell viability, especially in HeLa cells. When the apoptotic gene expressions were examined after treatment of extracts, the expression of many pro-apoptotic genes in both caspase-independent and caspase-dependent intrinsic and extrinsic pathways increased. These findings suggest that, considering that it had not led to irritation and toxicity in vivo, edible H. scoparia is a natural antioxidant and its apoptotic/cytotoxic activities can potentially be used against human cancers.Ege University BAP projectEge University [TUBITAK-2211]; [2013/FEN/015]Authors are appreciated to Assoc. Prof. Dr. Baykan, S., for her scientific contribution. The study was supported by TUBITAK-2211 Scholarship and Ege University BAP project (2013/FEN/015)

Transstomal Small Bowel Evisceration after Colonic Perforation Secondary to Ischemic Colitis

Intestinal stomas are commonly used in a temporary or permanent fashion in gastrointestinal surgeries. The complication rate of stomas has been reported to vary between 23 and 50%. There is only one case in the literature involving transstomal small bowel evisceration following colonic perforation. In this paper, we aimed to present a patient with a perforated colon secondary to ischemic colitis, which resulted in small bowel evisceration through this perforation site

Multi-Biomarker Responses After Exposure to Pollution in the Mediterranean Mussels (Mytilus galloprovincialis L.) in the Aegean Coast of Turkey

WOS: 000392321300009PubMed ID: 27921131In this study, sublethal effects on the Mediterranean mussels (Mytilus galloprovincialis L.) collected from the Aegean coast of Turkey were determined. Enzymes such as glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), and acetylcholinesterase (AChE), metallothionein (MT) mRNA expressions, thiobarbituric acid reactive substances (TBARS) contents, determination of 14 heavy metals and micronucleus frequency were selected as multibiomarkers. Results show that heavy metals and an increase in the level of MT gene expression have been determined in tissues of mussels collected from all stations. The GST, SOD and CAT enzymes were increased in mussels of Aliaga and Old Foca, compared to the mussels of Urla, while it was showed inhibition at AChE levels. Extensive LP is determined on mussels of Aliaga. It was determined that mussels in Aliaga region have exposed more oxidative stress than Old Foca and Urla. These biomarkers were carried out for the first time in these stations to assess environmental quality.Ege University BAP projectEge University [2012-CSUAM-003]The study is supported by Ege University BAP project (2012-CSUAM-003)