The role of forest resources in income inequality in Cameroon

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Additional file 1 of Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning

Supplementary Material 1: Figure 1. Flow chart demonstrating the number of AATD and Non-AATD patients at each research database and the respective recording perio

Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium.

PurposeIn young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population.MethodsA retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS.ResultsAmong the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%).ConclusionTrough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor

Proportion and associated risk ratio of complication classes for the young compared to old adult with ARDS.

Proportion and associated risk ratio of complication classes for the young compared to old adult with ARDS.</p

Number and percentage of patients per Elixhauser comorbidities for young adult patients with ARDS and non severe young adult patients.

Risk ratio associated in uni-variable analysis for the sub population which had previous hospital visits and considering only the ICD code related to those previous visits (one year and– 14 before the admission). (DOCX)</p

Number and percentage of patients per age groups, per sex, per Elixhauser comorbidities for young adult patients with ARDS and non severe young adult patients.

Risk ratio associated in uni- and multivariable analysis.</p

Complication classification.

(DOCX)</p

Flow chart.

Distribution of patients per group (y.o. = years old).</p

Name, city, country, number of hospitals per HS, number of beds and inpatient discharges/year per HS.

Name, city, country, number of hospitals per HS, number of beds and inpatient discharges/year per HS.</p

Number and percentage of patients per age groups, per sex, per Elixhauser comorbidities for all groups.

(DOCX)</p