Natural Gas Fermentation: A Promising Approach for Sustainably Meeting the World’s Growing Nutritional Demands

The rapid increase in world population, combined with the rising expectation for more nutritional diets in many rapidly developing economies, is creating a strong demand for the protein-rich materials used for human consumption and/or animal feed. Meeting such a demand is already exerting significant pressure on the environment and creating significant pressure for identifying and implementing more sustainable approaches for protein production and utilization. This looming problem needs to be addressed quickly, considering the recent accelerating rise in feed and food prices and their subsequent impact on the sociopolitical stability of several developing societies.This paper quickly reviews the environmental impact of current practices used for meeting the world's protein needs. It then introduces an environmentally-friendly novel approach for converting natural gas into Single Cell Protein that can be used as an ingredient in animal feed formulations. After reviewing the historical background for this approach and the various factors affecting its sustainability, the main impediments to its widespread adoption are discussed, and several means for enhancing the overall sustainability of the approach are presented.</p

Effect of Contaminants on the Gas Holdup and Mixing in Internal Airlift Reactors Equipped with Microbubble Generator

The impact of contaminants on the gas holdup and mixing characteristics encountered in internal airlift reactors was investigated using a 200 L pilot scale unit equipped with a two-phase transonic sparger capable of generating microbubbles. Small dosages of a cationic surfactant (0–50 ppm of sodium dodecyl sulfonate (SDS)) were used to simulate the coalescence-retarding effect encountered in most industrial streams and resulted in the formation of bubbles that varied in size between 280 and 1,900 μm. Gas holdups as high as 0.14 were achieved in the riser under homogeneous flow regime when slowly coalescent systems were aerated at the relatively low superficial velocity of 0.02 ms−1, whereas liquid circulation velocities as high as 1.3 ms−1 were achieved in conjunction with rapidly coalescent systems at the same superficial velocity. This excellent hydrodynamic performance represents a 5-fold improvement in the riser gas holdup and up to 8-fold enhancement in the liquid circulation velocity and is expected to yield good mixing and mass transfer performance at low energy dissipation rates

A service-based system for malnutrition prevention and self-management

Malnutrition is considered one of the root causes for the occurrence of other diseases. It is particularly common in the ageing population, where it requires more efficient handling and management to enable longer home independent living. However, to achieve this, a number of related challenges need to be overcome, especially those related to management of health and disease let alone other social and logistical barriers. This paper presents the design of a distributed system that enables homecare management in the context of self-feeding and malnutrition prevention through balanced nutritional intake. The design employs a service-based system that incorporates a number of services including monitoring of activities, nutritional reasoning for assessing feeding habits, diet recommendation for food planning, and marketplace invocation for automating food shopping to meet dietary requirements. The solution is deployed in a small pilot in 12 elder adult houses that, in early results, demonstrates its holistic user-centred scalable approach for malnutrition self-management

Integration operators for generating RDF/OWL-based user defined mediator views in a grid environment

Research and development activities relating to the grid have generally focused on applications where data is stored in files. However, many scientific and commercial applications are highly dependent on Information Servers (ISs) for storage and organization of their data. A data-information system that supports operations on multiple information servers in a grid environment is referred to as an interoperable grid system. Different perceptions by end-users of interoperable systems in a grid environment may lead to different reasons for integrating data. Even the same user might want to integrate the same distributed data in various ways to suit different needs, roles or tasks. Therefore multiple mediator views are needed to support this diversity. This paper describes our approach to supporting semantic interoperability in a heterogeneous multi-information server grid environment. It is based on using Integration Operators for generating multiple semantically rich RDF/OWL-based user defined mediator views above the grid participating ISs. These views support different perceptions of the distributed and heterogeneous data available. A set of grid services are developed for the implementation of the mediator views

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p&lt;0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p&lt;0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Sustainable Management of Climate Change: The Case of the Middle East and North Africa Region

<p><span style="font-size: medium;">Climate change is one of the major environmental challenges facing the world. Particularly vulnerable are arid and low-laying coastal areas, conditions that prevail through most of the Middle East and North Africa [MENA]. This region is an economically diverse one, including both the oil-rich economies in the Gulf and countries that are resource-scarce in relation to their population.  However, with about 23 percent of MENA’s population living on less than $2 a day, it is imperative that the climate change management strategies adopted be cost-effective and emphasize economic, social and human development while addressing the concerns arising from anthropogenic climate change.</span></p><p><span style="font-size: medium;">Over the past decades several national and international mechanisms were developed in an attempt to reduce the emissions considered to be mainly responsible for climate change, and to assist in coping with the adverse effects that are beginning to occur as a result of climate change. Unfortunately, many of these approaches are presently associated with economic penalties that often adversely affect the socio-economic welfare of the populace, particularly in low-, and medium-income countries. In this regard, it is informative to note the experience recently gained by Trinidad and Tobago [T&amp;T] in its attempt to reduce GHG emissions without affecting the competitiveness of the industrial and agricultural sectors. Using appropriate decision making tools and a policy environment based on a combination of regulations and incentives, the environmental challenges can be turned into a vehicle for sustainable development.</span></p><p><span style="font-size: medium;">This paper discusses the factors that need to be considered while developing a sustainable climate change management approach for the MENA region and develops some recommendations that may be essential for achieving the desired climate change mitigation/adaptation actions while minimizing social disruption.</span></p

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit