Epidemiology of inflammatory bowel disease in sub-Saharan Africa: A review of the current status

While inflammatory bowel disease (IBD) has been well characterised in the West and other parts of the world, there are little data from sub-Saharan Africa (SSA). To throw light on the current status of IBD in SSA, we performed a systematic review of the literature, extracting relevant publications. We found only 210 documented IBD cases in SSA (excluding South Africa (SA)), which were reported in 34 publications until August 2019. The majority were cases of ulcerative colitis. Only three reports, all from SA, attempted to determine IBD incidence rates. The rest were mostly case reports or small case series; the largest from Nigeria comprised 32 patients. The paucity of documented cases possibly reflects under-diagnosis and under-reporting. Major deficiencies in diagnostic and clinical capacity were noted, which need to be addressed going forward

ANTIMICROBIAL ACTIVITIES OF CRUDE METHANOLIC EXTRACT AND FRACTIONS OF THE BULB OF CRINUM JAGUS (LINN)

Crinum jagus is a medicinal plant used traditionally in Nigeria to treat infectious diseases such astuberculosis andmalaria. In the present study, the antimicrobial properties of the crude extract and chromatographic fractions from the bulb of Crinum jaguswere investigated against clinical and laboratoryisolates of bacteria and fungi using both agar well diffusion and agar dilution methods.Ampicillin (antibacterial) and tiaconazole(antifungal) were used as positive reference standard drugs.The crude plant extract and its fractionsdemonstrated broad spectrum activityagainst all the bacteriaand fungi isolatestested. Fraction 1 (24.00 mm zone of inhibition, MIC: 0.20 μg/mL, MBC:0.39μg/mL, MFC: 0.78μg/mL)demonstrated the highest activity, followed by Fraction 2 (24.00mm zone of inhibition, MIC: 0.39μg/mL, MBC: 0.78μg/mL, MFC: 1.56μg/mL. Fraction 3 (20:00mm zone of inhibition, MIC: 0.78μg/mL, MBC: 0.78μg/mL, MFC: 1.56μg/mL,). The crude extract howeverdemonstratedthe least activity against the test bacteria and fungi (18.00 mm zone of inhibition,MIC: 6.25mg/mL, MB: 25.00mg/mL, MFC: 50mg/mL.Preliminary phytochemical analysis revealed the presence of alkaloids, phenols, flavonoids,saponinsand steroids which may account for the antimicrobialactivity of theplant. The result of the study demonstrated that the extractand fractions of the bulb of Crinum jagus has appreciable antimicrobial properties and suggest that it may be useful in the treatment of microbial infections

Effect of Thermal Treatment on Chemical, Biological and Mechanical Properties of African Whitewood (Triplochiton scleroxylon K. SCHUM)

The thermal modification of wood is a potential alternative method for improving wood properties. This paper evaluates the effect of thermal treatment on the chemical, biological and mechanical properties of African Whitewood (Triplochiton scleroxylon K. Schum) by subjecting the wood to three temperature (200, 170, 140 ℃) at three different time (3, 6, 12 h). Fourier Transformed infrared (FT-IR) spectrometer was used to ascertain the effect of heat treatment on the chemical constituent of the wood while mechanical properties were determined by Modulus of Elasticity (MOE) and Modulus of Rupture (MOR). Durability of heat-treated wood against subterranean termites using field test was also investigated.  FTIR results provided information on the chemical constituents after heat treatment revealing the cellulose and hemicelluloses of Triplochiton scleroxylon wood samples. The decreasing intensity of hydroxyl groups stretching at 3341 cm-1 indicated that heat-treated samples have lost some of their hydroxyl groups. The results showed that the MOR of heated-treated wood at 200 ℃ was significantly higher than the untreated samples. There was also a 26% increase in the MOE of the 170 ℃ heat-treated wood relative to untreated samples. Wood samples thermally treated at 170 ℃ and 200 ℃ as well as untreated wood samples were strongly degraded in term of weight loss (WL) by termite though the degree of degradation varied based on temperature and time in which the wood was modified. However, heat-treated wood at 140 ℃ gave the lowest WL of 20.41% compared to other treated and untreated wood samples. Therefore, strength properties and termites’ resistance of African whitewood also known as Obeche wood in Nigeria could be improved when thermally modified at 170 ℃ and 140 ℃ respectively

Appraisal of Natural Durability of a Lesser – Known Boscia anguistifolia (A. Rich) Wood Using Ground Contact Test

The optimal utilization of lesser-known wood species is dependent on their natural durability. In this study, the natural durability of a lesser-known wood species (Boscia anguistifolia) using ground contact test was carried out. Wood blocks of Boscia anguistifolia and Ceiba petandra (reference species) with dimensions of 20 x 20 x 300 mm were obtained from the axial and radial direction of the trees. The wood blocks were conditioned and their moisture content determined before exposure to ground contact for 12 weeks after which their weight loss was determined. Data obtained were analysed using analysis of variance (ANOVA) at 0.05 probability level. The moisture content of B. anguistifolia and C. petandra ranged from 12.80 – 18.02 % and 12.73- 16.63%, respectively while the weight loss of B. anguistifolia and C. petandra ranged from 5.10 – 69.11% and 37 – 50 % respectively along the axial position. It was observed that the core wood in the base portion of B. anguistifolia has the lowest weight loss value of 5.10% while the reference species has a value of 39.73%. Conclusively, B. anguistifolia is moderately durable at the base part of the species when compared with the reference non-durable species used in this study

Impact of Irrigation on Midsummer Surface Fluxes and Temperature under Dry Synoptic Conditions: A Regional Atmospheric Model Study of the U.S. High Plains

The impact of irrigation on the surface energy budget in the U.S. high plains is investigated. Four 15-day simulations were conducted: one using a 1997 satellite-derived estimate of farmland acreage under irrigation in Nebraska (control run), two using the Olson Global Ecosystem (OGE) vegetation dataset (OGE wet run and OGE dry run), and the fourth with the Kuchler vegetation dataset (natural vegetation run) as lower boundary conditions in the Colorado State University Regional Atmospheric Modeling System (RAMS). In the control and OGE wet simulations, the topsoil in the irrigated locations, up to a depth of 0.2 m, was saturated at 0000 UTC each day for the duration of the experiment (1–15 July 1997). In the other two runs, the soil was allowed to dry out, except when replenished naturally by rainfall. Identical observed atmospheric conditions were used along the lateral boundary in all four cases. The area-averaged model-derived quantities for the grid centered over Nebraska indicate significant differences in the surface energy fluxes between the control (irrigated) and the ‘‘dry’’ simulations. For example, a 36% increase in the surface latent heat flux and a 2.68C elevation in dewpoint temperature between the control run and the OGE dry run is shown. Surface sensible heat flux of the control run was 15% less and the near-ground temperature was 1.28C less compared to the OGE dry run. The differences between the control run and the natural vegetation run were similar but amplified compared to the control run–OGE dry run comparisons. Results of statistical analyses of long-term(1921–2000) surface temperature data from two sites representing locations of extensive irrigated and nonirrigated land uses appear to support model results presented herein of an irrigationrelated cooling in surface temperature. Growing season monthly mean and monthly mean maximum temperature data for the irrigated site indicate a steady decreasing trend in contrast to an increasing trend at the nonirrigated site

Impact of Irrigation on Midsummer Surface Fluxes and Temperature under Dry Synoptic Conditions: A Regional Atmospheric Model Study of the U.S. High Plains

The impact of irrigation on the surface energy budget in the U.S. high plains is investigated. Four 15-day simulations were conducted: one using a 1997 satellite-derived estimate of farmland acreage under irrigation in Nebraska (control run), two using the Olson Global Ecosystem (OGE) vegetation dataset (OGE wet run and OGE dry run), and the fourth with the Kuchler vegetation dataset (natural vegetation run) as lower boundary conditions in the Colorado State University Regional Atmospheric Modeling System (RAMS). In the control and OGE wet simulations, the topsoil in the irrigated locations, up to a depth of 0.2 m, was saturated at 0000 UTC each day for the duration of the experiment (1–15 July 1997). In the other two runs, the soil was allowed to dry out, except when replenished naturally by rainfall. Identical observed atmospheric conditions were used along the lateral boundary in all four cases. The area-averaged model-derived quantities for the grid centered over Nebraska indicate significant differences in the surface energy fluxes between the control (irrigated) and the ‘‘dry’’ simulations. For example, a 36% increase in the surface latent heat flux and a 2.68C elevation in dewpoint temperature between the control run and the OGE dry run is shown. Surface sensible heat flux of the control run was 15% less and the near-ground temperature was 1.28C less compared to the OGE dry run. The differences between the control run and the natural vegetation run were similar but amplified compared to the control run–OGE dry run comparisons. Results of statistical analyses of long-term(1921–2000) surface temperature data from two sites representing locations of extensive irrigated and nonirrigated land uses appear to support model results presented herein of an irrigationrelated cooling in surface temperature. Growing season monthly mean and monthly mean maximum temperature data for the irrigated site indicate a steady decreasing trend in contrast to an increasing trend at the nonirrigated site

Evaluation of Antioxidant Activity of Tetracarpidium conophorum (Müll. Arg) Hutch & Dalziel Leaves

This study evaluated the antioxidant activity as well as bioflavonoid content of the methanol and ethanol-water extracts of the fresh and dried leaves of Tetracarpidium conophorum. Antioxidant activity was determined by spectrophotometric methods using DPPH free radical, nitric oxide radical inhibition and ferric reducing antioxidant power assays. In addition, total phenolics, flavonoids and proanthocyanidin content were also determined. The ethanol: water extract of the dried leaves had the highest antioxidant activity with a 50% inhibition of DPPH at a concentration of 0.017 mg/mL compared to the standards, Vitamin C and Vitamin E with inhibition of 0.019 and 0.011 mg/mL, respectively. This extract also showed nitric oxide radical inhibition activity comparable to that of rutin, 54.45% and 55.03% for extract and rutin, respectively, at 0.1 mg/mL. Ferric reducing power was also comparable to that of ascorbic acid (281 and 287 μM Fe (11)/g, resp.) at a concentration of 1 mg/mL. The methanol extract of both the dried and the fresh leaves had higher phenolic, flavonoids and proanthocyanidin content than the ethanol : water extract. The study reveals that T. conophorum can be an interesting source of antioxidants with their potential use in different fields namely food, cosmetics and pharmaceuticals

REPRODUCTIVE RESPONSE TO INCLUSION OF GRADED LEVELS OF Ipomoea purpurea LEAF MEAL (MORNING GLORY) IN DIETS OF LAYING CHICKENS

Reproductive responses of laying birds fed Ipomea purpurea leaf meal (IPML) were investigated. Atotal of 40, 25-weeks old birds grouped into four treatments of 0, 2.5, 5.0 and 7.5% inclusion levels of IPML were used for this experiment in a completely randomized design layout. The birds were artificially inseminated with semen from cockerels on controlled diet thrice in a week. A total of 400 eggs were collected and set in an incubator. There were no significant differences (p>0.05) in Hen day production,feed/dozen eggs and the egg characteristics investigated. The blood glucose levels significantly decreased (p<0.05) while level of progesterone significantly increased (p<0.05) with increase inlevel of IPLM inclusion. The percentages of fertility and hatchability were high while the survivability was 100%. It can be concluded that IPLM inclusion level of up to 7.50% supports high fertility, hatchability and survivability and could be used in breeder diets for the production of fertile eggs

Evaluation of Antioxidant Activity of Tetracarpidium conophorum (Müll. Arg) Hutch & Dalziel Leaves

This study evaluated the antioxidant activity as well as bioflavonoid content of the methanol and ethanol-water extracts of the fresh and dried leaves of Tetracarpidium conophorum. Antioxidant activity was determined by spectrophotometric methods using DPPH free radical, nitric oxide radical inhibition and ferric reducing antioxidant power assays. In addition, total phenolics, flavonoids and proanthocyanidin content were also determined. The ethanol: water extract of the dried leaves had the highest antioxidant activity with a 50% inhibition of DPPH at a concentration of 0.017 mg/mL compared to the standards, Vitamin C and Vitamin E with inhibition of 0.019 and 0.011 mg/mL, respectively. This extract also showed nitric oxide radical inhibition activity comparable to that of rutin, 54.45% and 55.03% for extract and rutin, respectively, at 0.1 mg/mL. Ferric reducing power was also comparable to that of ascorbic acid (281 and 287 μM Fe (11)/g, resp.) at a concentration of 1 mg/mL. The methanol extract of both the dried and the fresh leaves had higher phenolic, flavonoids and proanthocyanidin content than the ethanol : water extract. The study reveals that T. conophorum can be an interesting source of antioxidants with their potential use in different fields namely food, cosmetics and pharmaceuticals