Genotoxicity, haematological and growth performance of the African catfish Clarias gariepinus fingerlings fed walnut Tetracarpidium conophorum leaves to substitute for rice bran

A plant has become a preferred source of protein for fish species in aquaculture. A twelve-week feeding trial was carried out in order to assess the effect of feeding walnut leaves on haematological and biochemical parameters as well as the genotoxicity level on Clarias gariepinus fingerlings as a bio-indicator of their health status and overall response of the fish towards the experimental diets. One hundred and fifty fingerlings of Clarias gariepinus of mean weight 6.90±0.2g were stocked randomly as ten fish per tank (52.5 X 33.5 X 21 cm3) in triplicate. Fish were fed to satiation and the water changed every day to maintain good water quality. Five experimental diets with 40% crude protein each were formulated; the control, without the test ingredient and the other four diets (test diets1, 2, 3 and 4) contained 25%, 50%, 75% and 100% inclusion respectively. The Control diet had the highest mean weight gain (P < 0.05) (118.8±17.3) among the entire group. A similar pattern was observed in specific growth rate. The least significant (P < 0.05) feed conversion ratio was recorded by the Control diet(0.68±0.03), the diet also recorded the best protein efficiency ratio (3.53±0.23).The genotoxicity test shows that some Micronucleus of the test diets were normal, lobed and binucleated nucleus compared to the Control diet. The fish fed with T. conophorum showed a significant difference in haematological values when compared to the values of fish fed the control diet. The fish fed with T. conophorum showed a significant difference in biochemical value when compared with control diet. There was a reduction in the biochemical values of the fish fed T. Conophorum with Cholesterol (2.20±0.05) Albumin (8.35±0.21) and Triglyceride (0.98±0.13) compared with the values of fish fed with the control diet with cholesterol (3.81±0.07) Albumin (12.35±2.33) and Triglyceride (7.29±7.02). It was concluded that using T. Conophorum leaves as feed for Clarias gariepinus enhances the growth of the fish. Therefore, partial replacement of feed T. Conophorum should be encouraged

FogROS2-SGC: A ROS2 Cloud Robotics Platform for Secure Global Connectivity

The Robot Operating System (ROS2) is the most widely used software platform for building robotics applications. FogROS2 extends ROS2 to allow robots to access cloud computing on demand. However, ROS2 and FogROS2 assume that all robots are locally connected and that each robot has full access and control of the other robots. With applications like distributed multi-robot systems, remote robot control, and mobile robots, robotics increasingly involves the global Internet and complex trust management. Existing approaches for connecting disjoint ROS2 networks lack key features such as security, compatibility, efficiency, and ease of use. We introduce FogROS2-SGC, an extension of FogROS2 that can effectively connect robot systems across different physical locations, networks, and Data Distribution Services (DDS). With globally unique and location-independent identifiers, FogROS2-SGC securely and efficiently routes data between robotics components around the globe. FogROS2-SGC is agnostic to the ROS2 distribution and configuration, is compatible with non-ROS2 software, and seamlessly extends existing ROS2 applications without any code modification. Experiments suggest FogROS2-SGC is 19x faster than rosbridge (a ROS2 package with comparable features, but lacking security). We also apply FogROS2-SGC to 4 robots and compute nodes that are 3600km apart. Videos and code are available on the project website https://sites.google.com/view/fogros2-sgc.Comment: 9 pages, 8 figure

Can Machines Garden? Systematically Comparing the AlphaGarden vs. Professional Horticulturalists

The AlphaGarden is an automated testbed for indoor polyculture farming which combines a first-order plant simulator, a gantry robot, a seed planting algorithm, plant phenotyping and tracking algorithms, irrigation sensors and algorithms, and custom pruning tools and algorithms. In this paper, we systematically compare the performance of the AlphaGarden to professional horticulturalists on the staff of the UC Berkeley Oxford Tract Greenhouse. The humans and the machine tend side-by-side polyculture gardens with the same seed arrangement. We compare performance in terms of canopy coverage, plant diversity, and water consumption. Results from two 60-day cycles suggest that the automated AlphaGarden performs comparably to professional horticulturalists in terms of coverage and diversity, and reduces water consumption by as much as 44%. Code, videos, and datasets are available at https://sites.google.com/berkeley.edu/systematiccomparison.Comment: International Conference on Robotics and Automation(ICRA) 2023 Ora

FogROS2: An Adaptive Platform for Cloud and Fog Robotics Using ROS 2

Mobility, power, and price points often dictate that robots do not have sufficient computing power on board to run contemporary robot algorithms at desired rates. Cloud computing providers such as AWS, GCP, and Azure offer immense computing power on demand, but tapping into that power from a robot is non-trivial. We present FogROS2, an open-source platform to facilitate cloud and fog robotics that is compatible with the emerging Robot Operating System 2 (ROS 2) standard. FogROS2 is completely redesigned and distinct from its predecessor FogROS1 in 9 ways, and has lower latency, overhead, and startup times; improved usability, and additional automation, such as region and computer type selection. Additionally, FogROS2 was added to the official distribution of ROS 2, gaining performance, timing, and additional improvements associated with ROS 2. In examples, FogROS2 reduces SLAM latency by 50 %, reduces grasp planning time from 14 s to 1.2 s, and speeds up motion planning 28x. When compared to FogROS1, FogROS2 reduces network utilization by up to 3.8x, improves startup time by 63 %, and network round-trip latency by 97 % for images using video compression. The source code, examples, and documentation for FogROS2 are available at https://github.com/BerkeleyAutomation/FogROS2, and is available through the official ROS 2 repository at https://index.ros.org/p/fogros2

Aetiologies of profound bilateral sensorineural hearing loss among children in Ekiti State, South Western Nigeria

Introduction: a strong need exists for the knowledge of aetiologies of diseases as this will guide the clinicians on the strategies for their treatment and prevention. In this study, we determined the aetiologies of profound bilateral sensorineural hearing loss (pbSNHL) with a view to provide the relevant data needed for preventive and therapeutic intervention among children in Ekiti State, South Western Nigeria. Methods: medical records of children with pbSNHL seen over a ten-year period were analysed. Results: in all, records of 142 children with pbSNHL were analysed. The results showed spectrum of aetiologies that were similar to those reported decades ago with the 'unknown' assuming a recurring decimal. Of the known (acquired) cases, measles takes up the largest 'chunk' with a prevalence of 45.8%. Twenty-eight (32.2%) of those with febrile illnesses had treated their fever with ototoxic antibiotics. Late diagnosis was characteristic of the pbSNHL. Conclusion: this study shows that there hasn't been any significant shift in the common causes of pbSNHL. Of great concern is the persistence of the 'unknown' causes which assumes a recurring decimal in this and previous studies. Also worrisome is the high prevalence of measles-induced pbSNHL despite the availability of anti-measles vaccine. We therefore suggest effective immunization against measles and other vaccine-preventable causes of pbSNHL. The need for intensive research on the unknown causes of pbSNHL is hereby stressed. Also recommended is routine hearing assessment for survivors of febrile conditions so as to detect, if any, hearing loss promptly

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

Memorability rates of graphical password schemes

Passwords authentication has become a widely recognized element of computer security for confirming users' identity before access can be granted or repudiated to an intended information contents or applications of the system. Graphical password schemes are a login option that use images instead of alphanumeric strings for the purpose of user authentication. This alternative means of authentication is mainly designed to achieve good memorability and secutity of any choosen passwords based on widely known superiority effect of images over random strings. This paper provides a comprehensive survey of graphical password schemes and reports a memorability comparison between them. It also highlights how different memory tasks affect the graphical passwords and the relationship between the

Measles‑induced Hearing Loss: Pattern, Diagnosis, and Prevention among Children in Ekiti State, Southwest Nigeria

Background: Measles‑induced hearing loss is an otologic tragedy. In this study, we looked into the hypothesis that measles‑induced hearing loss may exhibit specific pattern the knowledge of which may guide clinicians on its diagnosis and prevention among children. Objective: The objective of the study was to describe the pattern, diagnosis, and prevention of measles‑induced hearing loss among children. Materials and Methods: This is a retrospective study of children with measles‑induced hearing loss in two tertiary hospitals. Results: In all, 112 children with measles‑induced hearing loss were studied. Majority (92.8%) were struck by the auditory shutdown at age 0.5–5 years. Most (87.5%) of the measles‑induced hearing losses were sensorineural with 73.5% of them being profound, bilateral, and irreversible. Majority were not diagnosed early due to a lack of visible or palpable diagnostic features. Majority (70.5%) of the children were not vaccinated against measles. Features suggestive of encephalitis were commonly associated with the profound sensorineural hearing loss. About 10% concomitantly used ototoxic antibiotics at the acute stage of the measles infection. About 84% of the children were deaf and dumb. Conclusion: This study shows that measles‑induced hearing loss often affects children around the age of speech acquisition leaving the victims deaf and dumb. Late diagnosis is characteristic of the auditory shutdown. The need to scale up effective antimeasles vaccination among children is hereby stressed. Routine postmeasles hearing assessment of victims is a practicable step to identify early those that require prompt rehabilitation with hearing aid or cochlear implant

Challenges in engaging the private sector for tuberculosis prevention and care in Nigeria: a mixed methods study

Objectives This study aimed to assess the practices of private practitioners regarding tuberculosis (TB), and to ascertain factors related to the low contribution of private healthcare providers to TB prevention and care in Nigeria.Design This is a mixed methods study comprising a quantitative retrospective review and qualitative study.Setting Private health facilities (HF) in Oyo State and the Federal Capital Territory (FCT), Nigeria.Participants We used routinely collected data on patients with tuberculosis (TB) notified between 1 January 2017 and 31 December 2018. In-depth interviews were also conducted with the clinical staff of the facilities.Primary and secondary outcome measures The study outcomes are practices of TB case notification and treatment outcome, as well as the barriers and enablers of TB notification.Results A total of 13 (11.0%) out of 118 private HF were designated as ‘engaged’ TB care facilities in Oyo State and none (0%) of the 198 private HF in the FCT held this designation. From the 214 patients with presumptive TB, 75 (35%) were diagnosed with TB, 42 (56%) had a bacteriological test done, 12 (16%) had an X-ray of the chest alone and 21 (28%) had other non-specific investigations. Most patients diagnosed were referred to a public HF, while 19 (25%) patients were managed at the private HF. Among them, 2 (10.5%) patients were treated with unconventional regimens, 4 (21%) were cured, 2 (11%) died, 3 (16%) lost to follow-up and 10 (53%) were not evaluated. The general practitioners did not have up-to-date knowledge of TB with a majority not trained on TB. Most referred patients with presumptive and confirmed TB to the public sector without feedback and were unclear regarding diagnostic algorithm and relevant tests to confirm TB.Conclusion Most private facilities were not engaged to provide TB services although with knowledge and practice gaps. The study has been used to develop plans for strategic engagement of the private sector in Nigeria