Predictions for the fracture toughness of cancellous bone of fracture neck of femur patients

Current protocol in determining if a patient is osteoporotic and their fracture risk is based on dual energy X-ray absorptiometry (DXA). DXA gives an indication of their bone mineral density (BMD) which is the product of both the porosity and density of the mineralized bone tissue; this is usually taken at the hip. The DXA results are assessed using the fracture risk assessment tool as recommended by the World Health Organization. While this provides valuable data on a person’s fracture risk advancements in medical imagining technology enables development of more robust and accurate risk assessment tools. In order to develop such tools in vitro analysis of bone is required to assess the morphological properties of bone osteoporotic bone tissue and how these pertain to the fracture toughness (Kcmax) of the tissue.Support was provided by the EPSRC (EP/K020196: Point-ofCare High Accuracy Fracture Risk Prediction), the UK Department of Transport under the BOSCOS (Bone Scanning for Occupant Safety) project, and approved by Gloucester and Cheltenham NHS Trust hospitals under ethical consent (BOSCOS – Mr. Curwen CI REC ref 01/179G)

Fermi-liquid effects in the gapless state of marginally thin superconducting films

We present low temperature tunneling density-of-states measurements in Al films in high parallel magnetic fields. The thickness range of the films, t=6-9 nm, was chosen so that the orbital and Zeeman contributions to their parallel critical fields were comparable. In this quasi-spin paramagnetically limited configuration, the field produces a significant suppression of the gap, and at high fields the gapless state is reached. By comparing measured and calculated tunneling spectra we are able to extract the value of the antisymmetric Fermi-liquid parameter G^0 and thereby deduce the quasiparticle density dependence of the effective parameter G^0_{eff} across the gapless state.Comment: 6 pages, 4 figure

Enhancement by cytotoxic agents of artificial pulmonary metastasis.

The formation of lung colonies by i.v. injected Lewis lung-tumour cells in syngeneic recipients was greatly enhanced by prior treatment of the mice with cyclophosphamide. The lung-cloning efficiency was linearly related to cyclophosphamide dose and the optimum time of treatment was 2-4 days before the injection of tumour cells. The resulting lung colonies had a similar size distribution to colonies in untreated recipients. Bleomycin, local thoraric irradiation and whole-body irradiation were much less effective in enhancing the lung-cloning efficiency. Cyclophosphamide also enhanced the take probability of i.m. implanted tumour cells

Dual Isomonodromic Deformations and Moment Maps to Loop Algebras

The Hamiltonian structure of the monodromy preserving deformation equations of Jimbo {\it et al } is explained in terms of parameter dependent pairs of moment maps from a symplectic vector space to the dual spaces of two different loop algebras. The nonautonomous Hamiltonian systems generating the deformations are obtained by pulling back spectral invariants on Poisson subspaces consisting of elements that are rational in the loop parameter and identifying the deformation parameters with those determining the moment maps. This construction is shown to lead to ``dual'' pairs of matrix differential operators whose monodromy is preserved under the same family of deformations. As illustrative examples, involving discrete and continuous reductions, a higher rank generalization of the Hamiltonian equations governing the correlation functions for an impenetrable Bose gas is obtained, as well as dual pairs of isomonodromy representations for the equations of the Painleve transcendents $P_{V}$ and $P_{VI}$.Comment: preprint CRM-1844 (1993), 28 pgs. (Corrected date and abstract.

Clonogenic assays in the B16 melanoma: response to cyclophosphamide.

The survival of clonogenic cells in the B16 melanoma has been studied simultaneously by 3 methods: an in vitro assay in soft agar, a lung-colony assay, and the end-point dilution technique. Details of the first 2 methods have previously been reported, but those of the third are described here. The 3 methods have agreed well in investigations of the response of the B16 melanoma to cyclophosphamide

Far-infrared vibrational properties of high-pressure-high-temperature C60 polymers and the C60 dimer

We report high-resolution far-infrared transmission measurements of the 2 + 2 cycloaddition C-60 dimer and two-dimensional rhombohedral and one-dimensional orthorhombic high-pressure high-temperature C60 polymers. In the spectral region investigated(20-650 cm(-1)), we see no low-energy interball modes, but symmetry breaking of the linked C-60 balls is evident in the complex spectrum of intramolecular modes. Experimental features suggest large splittings or frequency shifts of some IhC60-derived modes that are activated by symmetry reduction, implying that the balls are strongly distorted in these structures. We have calculated the vibrations of all three systems by first-principles quantum molecular dynamics and use them to assign the predominant IhC60 symmetries of observed modes. Pur calculations show unprecedentedly large downshifts of T-1u(2)-derived modes and extremely large splittings of other modes, both of which are consistent with the experimental spectra. For the rhombohedral and orthorhombic polymers, the T-1u(2)-derived mode that is polarized along the bonding direction is calculated to downshift below any T-1u(1)-derived modes. We also identify a previously unassigned feature near 610 cm(-1) in all three systems as a widely split or shifted mode derived from various silent IhC60 vibrations, confirming a strong perturbation model for these linked fullerene structures

Response of an atomic Bose-Einstein condensate to a rotating elliptical trap

We investigate numerically the response of an atomic Bose-Einstein condensate to a weakly-elliptical rotating trap over a large range of rotation frequencies. We analyse the quadrupolar shape oscillation excited by rotation, and discriminate between its stable and unstable regimes. In the latter case, where a vortex lattice forms, we compare with experimental observations and find good agreement. By examining the role of thermal atoms in the process, we infer that the process is temperature-independent, and show how terminating the rotation gives control over the number of vortices in the lattice. We also study the case of critical rotation at the trap frequency, and observe large centre-of-mass oscillations of the condensate.Comment: 14 pages, 8 figure

Hyperspherical Harmonics, Separation of Variables and the Bethe Ansatz

The relation between solutions to Helmholtz's equation on the sphere $S^{n-1}$ and the [{\gr sl}(2)]^n Gaudin spin chain is clarified. The joint eigenfuctions of the Laplacian and a complete set of commuting second order operators suggested by the $R$--matrix approach to integrable systems, based on the loop algebra \wt{sl}(2)_R, are found in terms of homogeneous polynomials in the ambient space. The relation of this method of determining a basis of harmonic functions on $S^{n-1}$ to the Bethe ansatz approach to integrable systems is explained.Comment: 14 pgs, Plain Tex, preprint CRM--2174 (May, 1994

Power Spectra of the Total Occupancy in the Totally Asymmetric Simple Exclusion Process

As a solvable and broadly applicable model system, the totally asymmetric exclusion process enjoys iconic status in the theory of non-equilibrium phase transitions. Here, we focus on the time dependence of the total number of particles on a 1-dimensional open lattice, and its power spectrum. Using both Monte Carlo simulations and analytic methods, we explore its behavior in different characteristic regimes. In the maximal current phase and on the coexistence line (between high/low density phases), the power spectrum displays algebraic decay, with exponents -1.62 and -2.00, respectively. Deep within the high/low density phases, we find pronounced \emph{oscillations}, which damp into power laws. This behavior can be understood in terms of driven biased diffusion with conserved noise in the bulk.Comment: 4 pages, 4 figure