Detection of an Optical Counterpart to the ALFALFA Ultra-compact High Velocity Cloud AGC 249525

We report on the detection at $>$98% confidence of an optical counterpart to AGC 249525, an Ultra-Compact High Velocity Cloud (UCHVC) discovered by the ALFALFA blind neutral hydrogen survey. UCHVCs are compact, isolated HI clouds with properties consistent with their being nearby low-mass galaxies, but without identified counterparts in extant optical surveys. Analysis of the resolved stellar sources in deep $g$- and $i$-band imaging from the WIYN pODI camera reveals a clustering of possible Red Giant Branch stars associated with AGC 249525 at a distance of 1.64$\pm$0.45 Mpc. Matching our optical detection with the HI synthesis map of AGC 249525 from Adams et al. (2016) shows that the stellar overdensity is exactly coincident with the highest-density HI contour from that study. Combining our optical photometry and the HI properties of this object yields an absolute magnitude of $-7.1 \leq M_V \leq -4.5$, a stellar mass between $2.2\pm0.6\times10^4 M_{\odot}$ and $3.6\pm1.0\times10^5 M_{\odot}$, and an HI to stellar mass ratio between 9 and 144. This object has stellar properties within the observed range of gas-poor Ultra-Faint Dwarfs in the Local Group, but is gas-dominated.Comment: 9 pages, 4 figures; accepted to ApJ

The Role of Parents\u27 Medication Beliefs, Religious Problem-Solving, and Risks for Treatment Nonadherence in Urban Families with Asthma

Childhood asthma is highly prevalent, affecting approximately nine million children in the United States. Negative effects of pediatric asthma are disproportionately experienced by ethnic minorities living in low-income, urban settings. Given the great diversity in families\u27 ways of addressing children\u27s asthma symptoms, sociocultural factors underlying asthma disparities must be examined. The current study investigated associations among parents\u27 beliefs about conventional and holistic/alternative medications, parents\u27 religious problem-solving strategies and childrens\u27 risks for asthma treatment nonadherence. The sample included 66 parents of ethnically diverse children with asthma living in urban settings. Factor analysis of the Religious Problem Solving Questionnaire yielded two factors, self-directed (ie, solving problems independently of God) and God-involved problem solving. Parents\u27 strong positive beliefs about conventional and alternative medications were associated with greater self-directed problem solving and with more risks for nonadherence. Higher levels of self-directed problem solving also were associated with more risks for nonadherence. Self-directed problem solving mediated the associations of conventional and alternative medication beliefs with risks for nonadherence. Possible explanations for findings are discussed

Innovating Pedagogy 2015: Open University Innovation Report 4

This series of reports explores new forms of teaching, learning and assessment for an interactive world, to guide teachers and policy makers in productive innovation. This fourth report proposes ten innovations that are already in currency but have not yet had a profound influence on education. To produce it, a group of academics at the Institute of Educational Technology in The Open University collaborated with researchers from the Center for Technology in Learning at SRI International. We proposed a long list of new educational terms, theories, and practices. We then pared these down to ten that have the potential to provoke major shifts in educational practice, particularly in post-school education. Lastly, we drew on published and unpublished writings to compile the ten sketches of new pedagogies that might transform education. These are summarised below in an approximate order of immediacy and timescale to widespread implementation

HIghMass - High HI Mass, HI-Rich Galaxies at z∼0z\sim0: Combined HI and H2_2 Observations

We present resolved HI and CO observations of three galaxies from the HIghMass sample, a sample of HI-massive ($M_{HI} > 10^{10} M_\odot$), gas-rich ($M_{HI}$ in top $5\%$ for their $M_*$) galaxies identified in the ALFALFA survey. Despite their high gas fractions, these are not low surface brightness galaxies, and have typical specific star formation rates (SFR$/M_*$) for their stellar masses. The three galaxies have normal star formation rates for their HI masses, but unusually short star formation efficiency scale lengths, indicating that the star formation bottleneck in these galaxies is in the conversion of HI to H$_2$, not in converting H$_2$ to stars. In addition, their dark matter spin parameters ($\lambda$) are above average, but not exceptionally high, suggesting that their star formation has been suppressed over cosmic time but are now becoming active, in agreement with prior H$\alpha$ observations.Comment: 20 pages, 13 figure

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.

Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the forkhead domain: Wing2 (around 50% of all mutations) and the highly conserved DNA-contact residue R219 (around 5% of all mutations). Wing2 mutations are detected in adenocarcinomas at all stages, whereas R219 mutations are enriched in metastatic tumours with neuroendocrine histology. Interrogation of the biological properties of wild-type FOXA1 and fourteen FOXA1 mutants reveals gain of function in mouse prostate organoid proliferation assays. Twelve of these mutants, as well as wild-type FOXA1, promoted an exaggerated pro-luminal differentiation program, whereas two different R219 mutants blocked luminal differentiation and activated a mesenchymal and neuroendocrine transcriptional program. Assay for transposase-accessible chromatin using sequencing (ATAC-seq) of wild-type FOXA1 and representative Wing2 and R219 mutants revealed marked, mutant-specific changes in open chromatin at thousands of genomic loci and exposed sites of FOXA1 binding and associated increases in gene expression. Of note, ATAC-seq peaks in cells expressing R219 mutants lacked the canonical core FOXA1-binding motifs (GTAAAC/T) but were enriched for a related, non-canonical motif (GTAAAG/A), which was preferentially activated by R219-mutant FOXA1 in reporter assays. Thus, FOXA1 mutations alter its pioneering function and perturb normal luminal epithelial differentiation programs, providing further support for the role of lineage plasticity in cancer progression

Stories of God\u27s Love: Preschool Program (Ages 3-4)

Stories of God’s Love is a Bible-based program prepared by a team of respected preschool specialists from the University of Dayton and is written following the directives developed by the U.S. Conference of Catholic Bishops. The leaflet style format proclaims age appropriate Bible stories as well as contemporary stories which connect the scripture story to an everyday life experience of a preschool child. Seasonal leaflets introduce and explore holy days, holidays and the seasons of the year. A music component, poster set and program director manual completes the program. Multi-day and one-day guides are available