Habitat Use of Ringed Seals (Phoca hispida) in the North Water Area (North Baffin Bay)

In conjunction with the International North Water Polynya Study in Smith Sound (northern Baffin Bay) in 1997-99, we examined the area use and diving activity of 23 ringed seals (Phoca hispida) that had been equipped with satellite transmitters on the Greenland side of the North Water (NOW) area. The study covered the period 12 August 1996-30 June 1999. Contact with the seals was maintained for an average of 108 days (range: 8-332 days). Four seals emigrated from the NOW area. During all seasons, the seals that remained in the area spent about 90% of the time in coastal (< 100 m deep) waters in the eastern parts of the NOW area. The total area visited by the seals during the open-water season ranged between 10 300 km² (1996) and 18 500 km² (1998), corresponding to about 15% to 25% of the entire NOW area. In winter, the total area visited by the seals varied between 2500 km² (1996-97) and 7000 km² (1998-99), and in spring, between 800 km² (1999) and 2100 km² (1997). Individual movement was significantly greater during the open-water season than during winter and spring. Maximum dive depths recorded were over 500 m (maximum for the instrument) outside and 376 m inside the NOW, for a 96 kg male seal. Non-adult seals spent about 99% of the time in waters less than 100 m deep, and more than 92% of the time in the upper 50 m. In contrast, adults tended to spend more time at greater depths. The study indicated that (1) the ringed seals took advantage of the generally lighter ice conditions in the eastern NOW, and (2) that non-adults likely exploited ice-associated amphipods and young polar cod (Boreogadus saida), and adults, mainly older polar cod and cephalopods taken at greater depths.Conjointement avec l'étude internationale sur la polynie de l'Eau du Nord dans le détroit de Smith (partie nord de la baie de Baffin) menée de 1997 à 1999, on a examiné l'utilisation de cette zone et l'activité de plongée de 23 phoques annelés (Phoca hispida) munis d'émetteurs-satellite du côté groenlandais de la région de l'Eau du Nord («NOW»). L'étude a couvert la période allant du 12 août 1996 au 30 juin 1999. Le contact avec les phoques a été maintenu pendant une moyenne de 108 jours (étendue: 8-332 jours). Quatre phoques ont émigré de la zone NOW. Durant toutes les saisons, les phoques qui restaient dans la zone passaient environ 90% du temps dans des eaux côtières (profondeur < 100 m) dans les secteurs orientaux de NOW. La superficie totale visitée par les phoques durant la saison d'eau libre allait de 10 300 km² (1996) à 18 500 km² (1998), correspondant à environ 15 à 25% de toute la zone NOW. En hiver, l'étendue totale fréquentée par les phoques allait de 2500 km² (1996-1997) à 7000 km² (1998-1999), et au printemps, de 800 km² (1999) à 2100 km² (1997). Les déplacements individuels étaient de beaucoup plus grands durant la saison d'eau libre qu'au cours de l'hiver et du printemps. Les profondeurs maximales de plongée enregistrées dépassaient 500 m (limite de l'instrument) à l'extérieur de la zone NOW et 376 m à l'intérieur, pour un phoque mâle de 96 kg. Les phoques non adultes passaient environ 99% du temps dans des eaux à une profondeur ne dépassant pas 100 m, et plus de 92% du temps dans les 50 m supérieurs. En revanche, les adultes avaient tendance à passer plus de temps à de plus grandes profondeurs. L'étude révèle 1) que les phoques annelés tiraient parti du fait qu'il y avait moins de glace dans la partie orientale de NOW, et 2) que, selon toute vraisemblance, les non-adultes exploitaient amphipodes et jeune morue polaire (Boreogadus saida) associés à la glace, les adultes se nourrissant surtout de morue polaire plus âgée et de céphalopodes prélevés à de plus grandes profondeurs

Resistin: A reappraisal

Abstract From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases. Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed

vitamin C, aging and Alzheimer's disease

Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging. Growing in vivo evidence supports the role of ascorbic acid in ameliorating factors linked to Alzheimer’s disease (AD) pathogenesis, although evidence in humans yielded equivocal results. The neuroprotective role of ascorbic acid not only relies on the general free radical trapping, but also on the suppression of pro-inflammatory genes, mitigating neuroinflammation, on the chelation of iron, copper, and zinc, and on the suppression of amyloid-beta peptide (Aβ) fibrillogenesis. Epidemiological evidence linking diet, one of the most important modifiable lifestyle factors, and risk of Alzheimer's disease is rapidly increasing. Thus, dietary interventions, as a way to epigenetically modulate the human genome, may play a role in the prevention of AD. The present review is aimed at providing an up to date overview of the main biological mechanisms that are associated with ascorbic acid supplementation/bioavailability in the process of aging and Alzheimer’s disease. In addition, we will address new fields of research and future directions.</jats:p

Toxoplasma gondii Tissue Cyst: Cyst Wall Incorporation Activity and Matrix Cytoskeleton Proteins Paving the Way to Nutrient Acquisition

Toxoplasma gondii is an intracellular parasite that causes chronic infection by the development of bradyzoites housed in tissue cysts, preferably in the muscles and central nervous system. The composition and the function of the cyst wall are still not fully understood. Are T. gondii cysts able to incorporate nutrients through its wall? If so, how would these nutrients be traversed to cross the cyst matrix to reach the bradyzoite forms? Herein, we tested the uptake capacity of the Toxoplasma tissue cyst wall by employing some fluid-phase endocytosis tracers as peroxidase (HRP) and bovine serum albumin (BSA). Fluorescence images revealed these molecules on the cyst wall as well as in the cyst matrix. The subcellular localization of the tracer was confirmed by ultrastructural analysis showing numerous labeled vesicles and tubules distributed within the cyst matrix in close association with intracystic bradyzoite membrane, suggesting the cyst wall as a route of nutrient uptake. Furthermore, we confirmed the presence of cytoskeleton proteins, such as tubulin, actin, and myosin, in the tissue cyst matrix that may explain the nutrient input mechanism through the cyst wall. A better understanding of the nutrient acquisition process by the cyst might potentially contribute to the development of new therapeutic targets against chronic toxoplasmosis

The boson-fermion model with on-site Coulomb repulsion between fermions

The boson-fermion model, describing a mixture of itinerant electrons hybridizing with tightly bound electron pairs represented as hard-core bosons, is here generalized with the inclusion of a term describing on-site Coulomb repulsion between fermions with opposite spins. Within the general framework of the Dynamical Mean-Field Theory, it is shown that around the symmetric limit of the model this interaction strongly competes with the local boson-fermion exchange mechanism, smoothly driving the system from a pseudogap phase with poor conducting properties to a metallic regime characterized by a substantial reduction of the fermionic density. On the other hand, if one starts from correlated fermions described in terms of the one-band Hubbard model, the introduction in the half-filled insulating phase of a coupling with hard-core bosons leads to the disappearance of the correlation gap, with a consequent smooth crossover to a metallic state.Comment: 7 pages, 6 included figures, to appear in Phys. Rev.

Quantum Monte Carlo and variational approaches to the Holstein model

Based on the canonical Lang-Firsov transformation of the Hamiltonian we develop a very efficient quantum Monte Carlo algorithm for the Holstein model with one electron. Separation of the fermionic degrees of freedom by a reweighting of the probability distribution leads to a dramatic reduction in computational effort. A principal component representation of the phonon degrees of freedom allows to sample completely uncorrelated phonon configurations. The combination of these elements enables us to perform efficient simulations for a wide range of temperature, phonon frequency and electron-phonon coupling on clusters large enough to avoid finite-size effects. The algorithm is tested in one dimension and the data are compared with exact-diagonalization results and with existing work. Moreover, the ideas presented here can also be applied to the many-electron case. In the one-electron case considered here, the physics of the Holstein model can be described by a simple variational approach.Comment: 18 pages, 11 Figures, v2: one typo correcte