937 research outputs found
High country river processes : a technical discussion of results from research on the Kowai River system, Springfield, Canterbury
A sub-catchment (Torlesse Stream) of the Kowai River, Canterbury, has been the site of an interdisciplinary study of the relationships between erosion and stream sedimentation (Hayward 1975). It was logical to extend the stream sediment investigation of that study (Hayward 1978) into the Kowai system proper in order to establish changes in the nature and distribution of the stream sediments with distance downstream.
The sediment sampling study, comprising Part I of Paper A in this volume, analyses the changes in size, distribution, form and rock type of the river gravels from ahead water mountain stream to the wide braided river beds of the middle reaches of the Kowai River. Part 2 of Paper A discusses the possible implications for the management that these sediment studies have for this and other similar river systems. It is believed that if thought necessary it is possible to design a river training programme to guide the river towards a more manageable pattern.
Paper B of this volume compares the results of the present river gravel survey with those from a sedimentological analysis of fluvio-glacial outwash gravels deposited several thousand years ago within the lower reaches of the Kowai system. This comparative study is used to indicate differences in the hydrologic environment prevailing at their respective times of deposition, and aids in our understanding of the processes at work in hill and high country rivers today.
Both Papers A and B relate to the Kowai River system, but the authors wish to emphasise that the findings from these studies are believed to have application to other similar gravel bed river systems
Organizational professionalism in globalizing law firms.
Are the challenges of globalization, technology and competition exercising a dramatic impact on professional practice whilst, in the process, compromising traditional notions of professionalism, autonomy and discretion? This paper engages with these debates and uses original, qualitative empirical data to highlight the vast areas of continuity that exist even the largest globalizing law firms. Whilst it is undoubted that growth in the size of firms and their globalization bring new challenges, these are resolved in ways that are sensitive to professional values and interests. In particular, a commitment to professional autonomy and discretion still characterises the way in which these firms operate and organize themselves. This situation is explained in terms of the development of an organizational model of professionalism, whereby the large organization is increasingly emerging as a primary locus of professionalization and whereby professional priorities and objectives are increasingly supported by organizational logics, systems and initiatives
Effect of somatic mutation on DNA binding properties of anti-DNA autoantibodies
Autoantibodies that bind DNA are a hallmark of systemic lupus erythematosus. A subset of autoantibodyâąDNA complexes localize to kidney tissue and lead to damage and even death. 11F8, 9F11, and 15B10 are clonally related anti-DNA autoantibodies isolated from an autoimmune mouse. 11F8 binds ssDNA in a sequence-specific manner and causes tissue damage, while 9F11 and 15B10 bind ssDNA non-specifically and are benign. Among these antibodies, DNA binding properties are mediated by five amino acid differences in primary sequence. Thermodynamic and kinetic parameters associated with recognition of structurally different DNA sequences were determined for each antibody to provide insight toward recognition strategies, and to explore a link between binding properties and disease pathogenesis. A model of 11F8 bound to its high affinity consensus sequence provides a foundation for understanding the differences in thermodynamic and kinetic parameters between the three mAbs. Our data suggest that 11F8 utilizes the proposed ssDNA recognition motif including Y32 V L , a hydrogen bonding residue at 91 V L , and an aromatic residue at the tip of the third heavy chain complementarity determining region. Interestingly, a somatic mutation to arginine at 31 V H in 11F8 may afford additional binding site contacts including R31 V H , R96 V H , and R98 V H that could determine specificity. © 2007 Wiley Periodicals, Inc. Biopolymers 85: 471â480, 2007. This article was originally published online as an accepted preprint. The âPublished Onlineâ date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected] Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55984/1/20691_ftp.pd
The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice
What lies beneath? The role of informal and hidden networks in the management of crises
Crisis management research traditionally focuses on the role of formal communication networks in the escalation and management of organisational crises. Here, we consider instead informal and unobservable networks. The paper explores how hidden informal exchanges can impact upon organisational decision-making and performance, particularly around inter-agency working, as knowledge distributed across organisations and shared between organisations is often shared through informal means and not captured effectively through the formal decision-making processes. Early warnings and weak signals about potential risks and crises are therefore often missed. We consider the implications of these dynamics in terms of crisis avoidance and crisis management
The abolition of the General Teaching Council for England and the future of teacher discipline
With the abolition of the General Teaching Council for England in the 2011 Education Act, this article considers the future of teacher discipline in England. It provides a critique of the changes to the regulation of teacher misconduct and incompetence that draws on a Foucauldian framework, especially concerning the issue of public displays of discipline and the concomitant movement to more hidden forms. In addition, the external context of accountability that accompanies the reforms to teacher discipline are considered including the perfection of the panoptic metaphor presented by the changes to Ofsted practices such as the introduction of zero-notice inspections. The article concludes that the reforms will further move teachers from being occupational professionals to being organisational professionals marking them apart from comparable professions in medicine and law
Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?
LARGE is a glycosyltransferase involved in glycosylation of α-dystroglycan (α-DG). Absence of this protein in the LARGEmyd mouse results in α-DG hypoglycosylation, and is associated with central nervous system abnormalities and progressive muscular dystrophy. Up-regulation of LARGE has previously been proposed as a therapy for the secondary dystroglycanopathies: overexpression in cells compensates for defects in multiple dystroglycanopathy genes. Counterintuitively, LARGE overexpression in an FKRP-deficient mouse exacerbates pathology, suggesting that modulation of α-DG glycosylation requires further investigation. Here we demonstrate that transgenic expression of human LARGE (LARGE-LV5) in the LARGEmyd mouse restores α-DG glycosylation (with marked hyperglycosylation in muscle) and that this corrects both the muscle pathology and brain architecture. By quantitative analyses of LARGE transcripts we also here show that levels of transgenic and endogenous LARGE in the brains of transgenic animals are comparable, but that the transgene is markedly overexpressed in heart and particularly skeletal muscle (20â100 fold over endogenous). Our data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP: in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle. Moreover, correction of LARGEmyd brain pathology with only moderate, near-physiological LARGE expression suggests a generous therapeutic window
Prenatal muscle development in a mouse model for the secondary dystroglycanopathies
The defective glycosylation of α-dystroglycan is associated with a group of muscular dystrophies that are collectively referred to as the secondary dystroglycanopathies. Mutations in the gene encoding fukutin-related protein (FKRP) are one of the most common causes of secondary dystroglycanopathy in the UK and are associated with a wide spectrum of disease. Whilst central nervous system involvement has a prenatal onset, no studies have addressed prenatal muscle development in any of the mouse models for this group of diseases. In view of the pivotal role of α-dystroglycan in early basement membrane formation, we sought to determine if the muscle formation was altered in a mouse model of FKRP-related dystrophy
Conversion of patellofemoral arthroplasty to total knee arthroplasty: A matched case-control study of 13 patients
Background and purpose The long-term outcome of patellofemoral arthroplasty is related to progression of femorotibial osteoarthritis with need for conversion to total knee arthroplasty. We investigated whether prior patellofemoral arthroplasty compromises the results of total knee arthroplasty
Preparing to work: dramaturgy, cynicism and normative âremoteâ control in the socialization of graduate recruits in management consulting
online) This paper examines the socialization of graduate recruits into a knowledge intensive labour
process and organizational culture. Theoretically the paper draws upon the idea of âpreparing
for workâ to position this early socialization as a crucial moment in the production of
subjectivities suited (and booted) for the labour process of management consulting. Empirically
the paper reports on a two-day induction session for new graduate recruits joining a global
management consultancy and their responses to this training. Particular attention is given to
the use of role-play and a dramaturgical workshop used in part of the training process. The paper
argues that the utilization of dramaturgy in training is consistent with the overall approach to
control developed in the firm in response to the fact that the labour process of consulting is
often conducted on client sites, away from any direct supervisory gaze. As such, the consultants
were subjected to a form of cultural control that was designed to function independently of
direct supervision. This control did not operate directly upon the new employees professed
values, however, but at one step removed so that a âcynical distanceâ from the content of the
organizationâs culture was accepted so long as a professional âethic of behaviourâ was
established. By focusing on an âethic of behaviourâ these young professionals were encouraged
to internalize a self-control akin to that of an actor, rather than internalizing the corporate values
entirely
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