Controlling Nonequilibrium Phonon Populations in Single-Walled Carbon Nanotubes

We studied spatially isolated single-walled carbon nanotubes (SWNTs) immobilized in a quasi-planar optical λ/2-microresonator using confocal microscopy and spectroscopy. The modified photonic mode density within the resonator is used to selectively enhance or inhibit different Raman transitions of SWNTs. Experimental spectra are presented that exhibit single Raman bands only. Calculations of the relative change in the Raman scattering cross sections underline the potential of our microresonator for the optical control of nonequilibrium phonon populations in SWNT

Controlling molecular broadband-emission by optical confinement

We investigate experimentally and theoretically the fluorescence emitted by molecular ensembles as well as spatially isolated, single molecules of an organic dye immobilized in a quasi-planar optical microresonator at room temperature. The optically excited dipole emitters couple simultaneously to on- and off-axis cavity resonances of the microresonator. The multi-spectral radiative contributions are strongly modified with respect to free (non-confined) space due to enhancement and inhibition of the molecular spontaneous emission (SpE) rate. By varying the mirror spacing of the microresonator on the nanometer-scale, the SpE rate of the cavity-confined molecules and, consequently, the spectral line width of the microresonator-controlled broadband fluorescence can be tuned by up to one order of magnitude. Stepwise reducing the optical confinement, we observe that the microresonator-controlled molecular fluorescence line shape converges towards the measured fluorescence line shape in free space. Our results are important for research on and application of broadband emitters in nano-optics and -photonics as well as microcavity-enhanced (single molecule) spectroscopy

Highly efficient, tunable single photon source based on single molecules

The authors studied spatially isolated terrylene molecules immobilized in a quasiplanar optical λ/2-microresonator using confocal microscopy and spectroscopy at variable temperatures. At T = 1.8 K, they observed individual molecules relaxing into microresonator-allowed vibronic levels of their electronic ground state by emission of single fluorescence photons. Coupling the purely electronic transition of embedded molecules to the longitudinal photonic mode of the microresonator resulted in an ultimate spectral narrowing and an increased collection efficiency of the emitted single photon wave trains

Exponential Decay Lifetimes of Excitons in Individual Single-Walled Carbon Nanotubes

The dynamics of excitons in individual semiconducting single-walled carbon nanotubes was studied using time-resolved photoluminescence (PL) spectroscopy. The PL decay from tubes of the same (n,m) type was found to be monoexponential, however, with lifetimes varying between less than 20 and 200 ps from tube to tube. Competition of nonradiative decay of excitons is facilitated by a thermally activated process, most likely a transition to a low-lying optically inactive trap state that is promoted by a low-frequency phonon mode

Nature of the constant factor in the relation between radial breathing mode frequency and tube diameter for single-wall carbon nanotubes

Resonance Raman scattering is used to determine the radial breathing mode (RBM) frequency (ωRBM) dependence on tube diameter (dt) for single-wall carbon nanotubes (SWNTs). We establish experimentally the ωRBM=227.0/dt as the fundamental relation for pristine SWNTs. All the other RBM values found in the literature can be explained by an upshift in frequency due mostly to van der Waals interaction between SWNTs and environment

Measuring the neutron star equation of state using X-ray timing

One of the primary science goals of the next generation of hard X-ray timing instruments is to determine the equation of state of the matter at supranuclear densities inside neutron stars, by measuring the radius of neutron stars with different masses to accuracies of a few percent. Three main techniques can be used to achieve this goal. The first involves waveform modelling. The flux we observe from a hotspot on the neutron star surface offset from the rotational pole will be modulated by the star's rotation, giving rise to a pulsation. Information about mass and radius is encoded into the pulse profile via relativistic effects, and tight constraints on mass and radius can be obtained. The second technique involves characterising the spin distribution of accreting neutron stars. The most rapidly rotating stars provide a very clean constraint, since the mass-shedding limit is a function of mass and radius. However the overall spin distribution also provides a guide to the torque mechanisms in operation and the moment of inertia, both of which can depend sensitively on dense matter physics. The third technique is to search for quasi-periodic oscillations in X-ray flux associated with global seismic vibrations of magnetars (the most highly magnetized neutron stars), triggered by magnetic explosions. The vibrational frequencies depend on stellar parameters including the dense matter equation of state. We illustrate how these complementary X-ray timing techniques can be used to constrain the dense matter equation of state, and discuss the results that might be expected from a 10m$^2$ instrument. We also discuss how the results from such a facility would compare to other astronomical investigations of neutron star properties. [Modified for arXiv]Comment: To appear in Reviews of Modern Physics as a Colloquium, 23 pages, 9 figure

Colloquium: Measuring the neutron star equation of state using x-ray timing

One of the primary science goals of the next generation of hard x-ray timing instruments is to determine the equation of state of matter at supranuclear densities inside neutron stars by measuring the radius of neutron stars with different masses to accuracies of a few percent. Three main techniques can be used to achieve this goal. The first involves waveform modeling. The flux observed from a hotspot on the neutron star surface offset from the rotational pole will be modulated by the star's rotation, and this periodic modulation at the spin frequency is called a pulsation. As the photons propagate through the curved spacetime of the star, information about mass and radius is encoded into the shape of the waveform (pulse profile) via special and general-relativistic effects. Using pulsations from known sources (which have hotspots that develop either during thermonuclear bursts or due to channeled accretion) it is possible to obtain tight constraints on mass and radius. The second technique involves characterizing the spin distribution of accreting neutron stars. A large collecting area enables highly sensitive searches for weak or intermittent pulsations (which yield spin) from the many accreting neutron stars whose spin rates are not yet known. The most rapidly rotating stars provide a clean constraint, since the limiting spin rate where the equatorial surface velocity is comparable to the local orbital velocity, at which mass shedding occurs, is a function of mass and radius. However, the overall spin distribution also provides a guide to the torque mechanisms in operation and the moment of inertia, both of which can depend sensitively on dense matter physics. The third technique is to search for quasiperiodic oscillations in x-ray flux associated with global seismic vibrations of magnetars (the most highly magnetized neutron stars), triggered by magnetic explosions. The vibrational frequencies depend on stellar parameters including the dense matter equation of state, and large-area x-ray timing instruments would provide much improved detection capability. An illustration is given of how these complementary x-ray timing techniques can be used to constrain the dense matter equation of state and the results that might be expected from a 10 m2 instrument are discussed. Also discussed are how the results from such a facility would compare to other astronomical investigations of neutron star properties

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or those with lesion activity on imaging. We sought to assess whether natalizumab slows disease progression in secondary progressive multiple sclerosis, independent of relapses. Methods: ASCEND was a phase 3, randomised, double-blind, placebo-controlled trial (part 1) with an optional 2 year open-label extension (part 2). Enrolled patients aged 18–58 years were natalizumab-naive and had secondary progressive multiple sclerosis for 2 years or more, disability progression unrelated to relapses in the previous year, and Expanded Disability Status Scale (EDSS) scores of 3·0–6·5. In part 1, patients from 163 sites in 17 countries were randomly assigned (1:1) to receive 300 mg intravenous natalizumab or placebo every 4 weeks for 2 years. Patients were stratified by site and by EDSS score (3·0–5·5 vs 6·0–6·5). Patients completing part 1 could enrol in part 2, in which all patients received natalizumab every 4 weeks until the end of the study. Throughout both parts, patients and staff were masked to the treatment received in part 1. The primary outcome in part 1 was the proportion of patients with sustained disability progression, assessed by one or more of three measures: the EDSS, Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9HPT). The primary outcome in part 2 was the incidence of adverse events and serious adverse events. Efficacy and safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01416181. Findings: Between Sept 13, 2011, and July 16, 2015, 889 patients were randomly assigned (n=440 to the natalizumab group, n=449 to the placebo group). In part 1, 195 (44%) of 439 natalizumab-treated patients and 214 (48%) of 448 placebo-treated patients had confirmed disability progression (odds ratio [OR] 0·86; 95% CI 0·66–1·13; p=0·287). No treatment effect was observed on the EDSS (OR 1·06, 95% CI 0·74–1·53; nominal p=0·753) or the T25FW (0·98, 0·74–1·30; nominal p=0·914) components of the primary outcome. However, natalizumab treatment reduced 9HPT progression (OR 0·56, 95% CI 0·40–0·80; nominal p=0·001). In part 1, 100 (22%) placebo-treated and 90 (20%) natalizumab-treated patients had serious adverse events. In part 2, 291 natalizumab-continuing patients and 274 natalizumab-naive patients received natalizumab (median follow-up 160 weeks [range 108–221]). Serious adverse events occurred in 39 (13%) patients continuing natalizumab and in 24 (9%) patients initiating natalizumab. Two deaths occurred in part 1, neither of which was considered related to study treatment. No progressive multifocal leukoencephalopathy occurred. Interpretation: Natalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component. Longer-term trials are needed to assess whether treatment of secondary progressive multiple sclerosis might produce benefits on additional disability components. Funding: Biogen