63 research outputs found

    Transforming conservation science and practice for a postnormal world

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    In this essay we highlight issues to consider when reframing conservation objectives and outcomes in the context of global change. We discuss (1) new framings of the links between ecosystems and society; (2) new relationships and roles for conservation science; (3) new models of how conservation links to society and social change and (4) new approaches for implementing adaptation for conservation outcomes. We argue that reframing conservation objectives requires conservation scientists and practitioners to implement approaches that are no longer constrained by discipline and sectoral boundaries, geopolitical polarities, or technical problematisation. We consider that a stronger focus on learning and inclusive co-creation of knowledge, and its interaction with societal values and rules, is likely to result in conservation science and practice that will be able to meet the challenges of a post-normal world

    Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

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    The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than calcineurin-NFATc, too. To answer the major open question - whether the adverse side effects are secondary to the actions of the drugs on the calcineurin-NFATc pathway - alternative inhibitors were developed. Ideal inhibitors should discriminate between the inhibition of (i) calcineurin and peptidyl-prolyl cis-trans isomerases (PPIases; the matchmaker proteins of CsA and FK506), (ii) calcineurin and the other Ser/Thr protein phosphatases, and (iii) NFATc and other transcription factors. In this review we summarize the current knowledge about novel inhibitors, synthesized or identified in the last decades, and focus on their mode of action, specificity, and biological effects
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