Toward Constraintless Time-Correlated Single-Photon Counting Measurements: A New Method to Remove Pile-up Distortion

Time-Correlated Single-Photon Counting (TCSPC) is a well-renowned technique allowing to reconstruct light signals with high sensitivity and resolution. Nevertheless, to this day, its use in applications requiring a fast analysis of the sample is limited due to its long acquisition time. The reason is twofold: on one hand, it is based on a statistical method thus requiring the collection of a large number of events to properly reconstruct the signal waveform; on the other hand, the average number of photons impinging on the sensor has to be kept particularly low to avoid artifacts. Indeed, the existence of dead time of both single-photon detectors and electronics can lead to distortion in the reconstructed waveform, which can be mitigated only if the count rate is kept below few percent of the excitation frequency. Recently, it has been demonstrated that an appropriate tuning of detector dead time allows to remove such power restriction, but, unfortunately, this constraint also sets a limit to the maximum count rate of the detector. In this paper, we present a novel method for TCSPC measurements, which ensures negligible distortion at unprecedented rates without requiring any constraint on either illumination power or detector dead time. We will show that this is possible thanks to the acquisition of additional information on the status of TCSPC system. The theoretical analysis reported in this paper is supported by analytical computation and numerical simulation, taking into account also potential non idealities of a real implementation

Timing measurements with silicon single photon avalanche diodes: principles and perspectives [Invited]

Picosecond timing of single photons has laid the foundation of a great variety of applications, from life sciences to quantum communication, thanks to the combination of ultimate sensitivity with a bandwidth that cannot be reached by analog recording techniques. Nowadays, more and more applications could still be enabled or advanced by progress in the available instrumentation, resulting in a steadily increasing research interest in this field. In this scenario, single-photon avalanche diodes (SPADs) have gained a key position, thanks to the remarkable precision they are able to provide, along with other key advantages like ruggedness, compactness, large signal amplitude, and room temperature operation, which neatly distinguish them from other solutions like superconducting nanowire single-photon detectors and silicon photomultipliers. With this work, we aim at filling a gap in the literature by providing a thorough discussion of the main design rules and tradeoffs for silicon SPADs and the electronics employed along them to achieve high timing precision. In the end, we conclude with our outlook on the future by summarizing new routes that could benefit from present and prospective timing features of silicon SPADs

A 4.5 ps precision TCSPC system: design principles and characterization

With the recent advancements in single-photon detectors, very low-jitter timing systems are required to fully exploit their performance in real applications. In this article, we present the design principles and experimental characterization of a single-channel time-correlated single-photon counting (TCSPC) system, that achieves a jitter down to 4.5 ps FWHM, a peak-to-peak differential nonlinearity of 1.5 % LSB and a count rate of 12 Mcps over a nanoseconds full-scale range. These results have been attained by minimizing the different jitter contributions that are introduced at various levels in the whole timing chain, still without trading them off with the other performance parameters. To the best of our knowledge, this work represents the state-of-the-art performance in case of a full-scale range as large as 12.5 ns

Readout Architectures for High Efficiency in Time-Correlated Single Photon Counting Experiments—Analysis and Review

In recent years, time-correlated single photon counting (TCSPC) has become the technique of choice in many life science analyses, where fast and faint luminous signals are recorded with picosecond accuracy. Nevertheless, the maximum operating frequency of a single TCSPC acquisition channel limits the measurement speed, especially when scanning point systems are exploited. In order to increase the speed of TCSPC experiments, many multichannel systems based on single photon avalanche diode arrays have been proposed in the literature, which integrate thousands of pixels on the same chip. Unfortunately, the huge number of data generated by this kind of system can easily bring to the saturation of the transfer bandwidth to the external processing unit. For this reason, several different readout architectures have been proposed in the literature, attempting to exploit at best the limited bandwidth under TCSPC operating conditions. In this paper, some typical readout approaches, namely clock-driven and event-driven readouts, are discussed and compared, along with a recently-introduced router-based algorithm that is specifically designed to obtain maximum bandwidth exploitation under any condition. Quantitative comparisons are performed starting from imager response of the systems, which is the rate of recorded events in the case of uniform illumination of the detector array

A 1.9 ps-rms Precision Time-to-Amplitude Converter With 782 fs LSB and 0.79%-rms DNL

Measuring a time interval in the nanoseconds range has opened the way to 3-D imaging, where additional information as distance of objects light detection and ranging (LiDAR) or lifetime decay fluorescence-lifetime imaging (FLIM) is added to spatial coordinates. One of the key elements of these systems is the time measurement circuit, which encodes a time interval into digital words. Nowadays, most demanding applications, especially in the biological field, require time-conversion circuits with a challenging combination of performance, including sub-ps resolution, ps precision, several ns of measurement range, linearity better than few percent of the bin width (especially when complex lifetime data caused by multiple factors have to be retrieved), and operating rates in the order of tens of Mcps. In this article, we present a time-to-amplitude converter (TAC) implemented in a SiGe 350 nm process featuring a resolution of 782 fs, a minimum timing jitter as low as 1.9 ps-rms, a DNL down to 0.79% LSB-rms, and conversion rate as high as 12.3 Mcps. With an area occupation of 0.2 mm2 [without PADs and digital-to-analog converter (DAC)], a FSR up to 100 ns, and a power dissipation of 70 mW, we developed a circuit suitable to be the core element of a densely integrated, faster and high-performance system

Recent advances and future perspectives of single-photon avalanche diodes for quantum photonics applications

Photonic quantum technologies promise a revolution of the world of information processing, from simulation and computing to communication and sensing, thanks to the many advantages of exploiting single photons as quantum information carriers. In this scenario, single-photon detectors play a key role. On the one hand, superconducting nanowire single-photon detectors (SNSPDs) are able to provide remarkable performance on a broad spectral range, but their applicability is often limited by the need of cryogenic operating temperatures. On the other hand, single-photon avalanche diodes (SPADs) overcome the intrinsic limitations of SNSPDs by providing a valid alternative at room temperature or slightly below. In this paper, we review the fundamental principles of the SPAD operation and we provide a thorough discussion of the recent progress made in this field, comparing the performance of these devices with the requirements of the quantum photonics applications. In the end, we conclude with our vision of the future by summarizing prospects and unbeaten paths that can open new perspectives in the field of photonic quantum information processing

High-efficiency integrated readout circuit for single photon avalanche diode arrays in fluorescence lifetime imaging

In recent years, lifetime measurements by means of the Time Correlated Single Photon Counting (TCSPC) technique have led to a significant breakthrough in medical and biological fields. Unfortunately, the many advantages of TCSPC-based approaches come along with the major drawback of a relatively long acquisition time. The exploitation of multiple channels in parallel could in principle mitigate this issue, and at the same time it opens the way to a multi-parameter analysis of the optical signals, e.g., as a function of wavelength or spatial coordinates. The TCSPC multichannel solutions proposed so far, though, suffer from a tradeoff between number of channels and performance, and the overall measurement speed has not been increased according to the number of channels, thus reducing the advantages of having a multichannel system. In this paper, we present a novel readout architecture for bi-dimensional, high-density Single Photon Avalanche Diode (SPAD) arrays, specifically designed to maximize the throughput of the whole system and able to guarantee an efficient use of resources. The core of the system is a routing logic that can provide a dynamic connection between a large number of SPAD detectors and a much lower number of high-performance acquisition channels. A key feature of our smart router is its ability to guarantee high efficiency under any operating condition

Fast fully-integrated front-end circuit to overcome pile-up limits in time-correlated single photon counting with single photon avalanche diodes

Time-Correlated Single Photon Counting (TCSPC) is an essential tool in many scientific applications, where the recording of optical pulses with picosecond precision is required. Unfortunately, a key issue has to be faced: distortion phenomena can affect TCSPC experiments at high count rates. In order to avoid this problem, TCSPC experiments have been commonly carried out by limiting the maximum operating frequency of a measurement channel below 5% of the excitation frequency, leading to a long acquisition time. Recently, it has been demonstrated that matching the detector dead time to the excitation period allows to keep distortion around zero regardless of the rate of impinging photons. This solution paves the way to unprecedented measurement speed in TCSPC experiments. In this scenario, the front-end circuits that drive the detector play a crucial role in determining the performance of the system, both in terms of measurement speed and timing performance. Here we present two fully integrated front-end circuits for Single Photon Avalanche Diodes (SPADs): a fast Active Quenching Circuit (AQC) and a fully-differential current pick-up circuit. The AQC can apply very fast voltage variations, as short as 1.6ns, to reset external custom-technology SPAD detectors. A fast reset, indeed, is a key parameter to maximize the measurement speed. The current pick-up circuit is based on a fully differential structure which allows unprecedented rejection of disturbances that typically affect SPAD-based systems at the end of the dead time. The circuit permits to sense the current edge resulting from a photon detection with picosecond accuracy and precision even a few picoseconds after the end of the dead time imposed by the AQC. This is a crucial requirement when the system is operated at high rates. Both circuits have been deeply characterized, especially in terms of achievable measurement speed and timing performance

Improving the counting efficiency in time-correlated single photon counting experiments by dead-time optimization

Time-Correlated Single Photon Counting (TCSPC) has been long recognized as the most sensitive method for fluorescence lifetime measurements, but often requiring “long” data acquisition times. This drawback is related to the limited counting capability of the TCSPC technique, due to pile-up and counting loss effects. In recent years, multi-module TCSPC systems have been introduced to overcome this issue. Splitting the light into several detectors connected to independent TCSPC modules proportionally increases the counting capability. Of course, multi-module operation also increases the system cost and can cause space and power supply problems. In this paper, we propose an alternative approach based on a new detector and processing electronics designed to reduce the overall system dead time, thus enabling efficient photon collection at high excitation rate. We present a fast active quenching circuit for single-photon avalanche diodes which features a minimum dead time of 12.4 ns. We also introduce a new Time-to-Amplitude Converter (TAC) able to attain extra-short dead time thanks to the combination of a scalable array of monolithically integrated TACs and a sequential router. The fast TAC (F-TAC) makes it possible to operate the system towards the upper limit of detector count rate capability (∼80 Mcps) with reduced pile-up losses, addressing one of the historic criticisms of TCSPC. Preliminary measurements on the F-TAC are presented and discussed