Association of Serum Adropin Levels with Nutritional Status and Lipid Profile in Patients with Kidney Failure with Replacement Therapy

Objective. This study aimed to determine serum adropin levels and to examine the relationship of serum adropin levels with nutritional status and lipid profile in patients with kidney failure with replacement therapy (KFRT). Methods. The study consisted of 88 subjects, including 30 patients treated with hemodialysis (HD), 29 patients treated with peritoneal dialysis (PD), and 29 patients who had undergone kidney transplantation (TX). The study included assessing anthropometric measurements, handgrip strength, bioelectrical impedance analysis, malnutrition-inflammation score, dietary intake, resting energy expenditure, and biochemical parameters. The patients’ food consumption was recorded for three days. The malnutrition-inflammation score (MIS) was calculated to assess the patients’ nutritional status. Blood samples were collected for serum adropin and other biochemical parameters. Results. Adropin levels were significantly higher in the TX group when compared to the HD group. Patients with low adropin levels had higher MIS, serum ferritin, and lower low-density lipoprotein-cholesterol (LDL-C) and total cholesterol (total-C) levels. Serum adropin levels were negatively correlated with the MIS and positively correlated with total-C, LDL-C, and HDL-C levels. Multiple linear regression analyses showed that the MIS (β=-0.25 p=0.038) and LDL-C level (β=0.29, p=0.007) were associated with serum adropin. Conclusions. Adropin may be considered as a new marker of nutritional status and possibly plays a role in the pathophysiological mechanisms and complications of patients with KFRT

Effect of Circadian Rhythm on Metabolic Processes and the Regulation of Energy Balance.

The circadian timing system or circadian clock plays a crucial role in many biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular health, glucose homeostasis, and body temperature regulation. Energy balance is also one of the most important cornerstones of metabolic processes, whereas energy imbalance is associated with many diseases (i.e., obesity, diabetes, cardiovascular disease). Circadian clock is the main regulator of metabolism, and this analysis provides an overview of the bidirectional effect of circadian rhythm on metabolic processes and energy balance

Bileşimi ve Sağlık Üzerine Etkileri Açısından; Eşek ve Keçi Sütü

İnsan beslenmesinde önemli bir yere sahip olan inek sütünün neden olduğu bazı alerjik reaksiyonlar diğer sütlere yönelik çalışmaların yapılması ihtiyacını gündeme getirmiştir. Keçi sütüyle birlikte, son yıllarda eşek sütüne olan ilgi artmaktadır. Bu iki süt farklı özellikleriyle ön plana çıkmaktadır. Keçi sütünün protein fraksiyonu ve miktarının inek sütünden farklı olmaması alerjenite potansiyelini arttırmaktadır. Buna karşın yüksek MCT içeriği onu hiperlipidemi, pankreas hastalıkları, kistik fibrozis gibi yağ metabolizmasında sorun olan hastalarda önerilebilir yapmaktadır. Eşek sütü protein ve solüt yük miktarı bakımından anne sütü ile yakın değerlere sahiptir. Bu durum onu diğer sütlere göre hipoalerjen yapmaktadır. Yüksek laktoz içeriği çocuklar için kullanımını kolay hale getirmektedir. Eşek sütünün anne sütü- ne bu kadar yakın olması anne sütü alamayan bebekler için bir alternatif olabileceğini göstermektedir. Ayrıca yaşlı gruplarda ve immün yetersizlik görülen kişilerde kullanımının yaygınlaşacağı ve ülkemizde de eşek çiftliklerinin kurulmaya başlandığı görülmektedir

Assessment of Nutritional Status and Metabolic Syndrome in Peritoneal Dialysis Patients: A Pilot Study

Sanlier, Nevin/0000-0001-5937-0485WOS: 000406370100010Aim: Nutritional deficiencies and metabolic syndrome ( MS) is challenge in chronic kidney disease patients with peritoneal dialysis(PD). This study was planned in order to assess the nutritional status and metabolic syndrome in PD patients. Methods: This study was performed on clinically stable patients that were undergoing PD therapy. Energy and nutrient intakes were determined with consequently three days dietary record. The statement of MS was identified according to MS criteria adopted for PD patients. Results: The prevalence of MS was found 64.3%. The mean duration of PD in with-MS(35.4 +/- 25.23mo.) was lower than without- MS(44.3 +/- 30.99mo.) (p> 0.05). Patients with MS had significantly greater systolic/ diastolic blood pressure and lower high- density- lypoprotein cholesterol levels (HDL-C) ( p< 0.05). According to the body mass index (BMI), the 83.3% of patients' with- MS and 30% without- MS were found overweight and body fat mass was significant higher in patients with- MS(p< 0.05). The mean daily protein intakes per kilograms of body weight determined lower with- MS patients (0.8 +/- 0.25g/kg) than without- MS (0.9 +/- 0.29 g/kg). Conclusion: The prevalence of MS is remarkably high. The daily dietary energy and protein intakes were found under the recommended levels. Inadequate energy and protein intake increase loss of muscle mass and also excessive energy intake leads to obesity. Monitoring of nutritional status of PD patients is important both in prevention and progression of MS

Validation of predictive equations for resting energy expenditure in children and adolescents with different body mass indexes

Abstract Background Accurate estimation of resting energy expenditure (REE) in children and adolescents is important to establish estimated energy requirements. The objective of this study was to assess the validity of existing equations in literature and a newly developed equation in estimating REE in children and adolescents. Methods 275 participants (148 boys, 127 girls) aged 6–18 years included in the study were classified as normal-weighted, overweight, obese based on BMI z-scores for age according to WHO-2007 growth curves for 5–19 years of age. REEs were measured using an indirect calorimeter, with various equations, and a newly established equation [REE = 505.412+(24.383*FFM);Adjusted R2 = 0.649] were compared with REE measured using Bland-Altman and further validation parameters. Results When the predicted REEs were compared with the measured REEs, the highest prediction accuracy was achieved using the new Eq. (64.8%) and IOM (63.8%) for normal-weight participants, Müller FFM and new Eq. (59.6%) for overweight participants and Lazzer (44.9%) for obese participants. In normal and overweight participants, lowest root mean squared error (RMSE) values were acquired from Schmelzle’s equation (respectively 136.2;159.9 kcal/d), and the highest values were found in Kim’s Eq. (315.2; 295.2 kcal/d respectively). RMSE value of the new equation was 174.7 kcal/d for normal-weight children and adolescents, and 201.9 kcal/d for overweight ones. In obese participants, the lowest RMSE value was obtained from Schmelzle’s Eq. (305.4 kcal/d) and the new Eq. (317.4 kcal/d), while the highest value was obtained from IOM Eq. (439.9 kcal/d). RMSE was higher in obese groups compared to the other BMI groups. Conclusion Indirect-calorimeter is the most suitable method for REE measurement in especially obese children and adolescents. The new equation and Schmelzle’s equation appear to be most accurate equations for normal and overweight children and adolescents