Effect of moisture on cadmium sulfide solar cells

Moisture effect on thin-film cadmium-sulfide solar cell

Magnetic control of DTT alternative plasma configurations

One of the main challenges concerning next generation tokamaks (such as DEMO) will be the development of a heat and power exhaust system able to withstand the large loads expected in the divertor region. A dedicated Divertor Tokamak Test (DTT) facility has been proposed in the EUROfusion Roadmap, with the aim of testing unconventional solutions, such as advanced magnetic configurations and liquid metal divertors. Magnetic control of alternative plasma configurations, such as the X-Divertor, will play a key role in the solution of the heat exhaust and yet can be a challenging point, due to increased sensitivity introduced by secondary x-points. To overcome the complications introduced by secondary x-points in advanced plasma shapes, magnetic control in DTT is achieved by resolving to the eXtreme Shape Controller, in order to control both the plasma shape and the secondary x-point position

Mechanized recovery of olive pruning residues: ash contamination and harvesting losses

Agricultural residues represent an important source of biomass for energy. Among the available biomass suitable for energy and available in Italy, pruning represents about the 20% of the total. About 1.184 million of hectares are planted with olive trees; the pruning residues coming from these plantations represent a wide source of biomass at National level. The authors tested six commercial pruning harvesters to determine harvesting losses and product contamination when recovering pruning residues. All harvesters used a mechanical pick-up to collect the residues and a shredder to reduce them into chips. Three different pick-up settings were tested and namely: 1 cm above ground level, manufacturer’s specification and 3 cm above ground level. Ash content in the shredded material was taken as a measure of contamination: the uncontaminated branch material collected directly from the trees had a value of 3.5%, whereas in shredded residues varied between 4.5% and over 5.5%, for the shortest and the longest distance between the pick-up and the soil surface, respectively. Harvesting losses were slightly, but significantly, related to pick-up setting, and mainly depended on machine type. Both machines have shown a good quality of the work performed and the results obtained indicates that the work phases could be simplified in order to reduce both the time of use and the harvesting costs

Increasing HPV vaccination uptake among adolescents: A systematic review

Human Papillomavirus (HPV) vaccination is a well-known fundamental strategy in the prevention of cervical cancer, as it is always caused by HPV infection. In fact, primary prevention of the infection corresponds to primary prevention of HPV-related cancers and other diseases. Since an effective prevention at the population level is the final goal, it is mandatory for healthcare systems to achieve a high HPV vaccination coverage among the adolescents to reduce the circulation of the virus and the burden of HPV-related diseases. This research identified, through a systematic literature review, 38 papers on strategies adopted to increase HPV vaccination coverage among adolescents. The evaluated strategies targeted adolescents/parents and/or healthcare providers and could be grouped in three main types: (1) reminder-based, (2) education, information, and communication activities, and (3) multicomponent strategies. Several types of strategy, such as those relied only on reminders and integrating different interventions, showed a positive impact on vaccination coverage. Nonetheless, the heterogeneity of the interventions suggests the importance to adapt such strategies to the specific national/local contexts to maximize vaccination coverage

Relationship between cardiovascular health metrics and physical performance in community-living people: Results from the Longevity check-up (Lookup) 7+ project

Cardiovascular health metrics (CHMs) may predict disability independent of vascular events. Though, the link between CHMs and physical performance is unclear. This relationship was explored using data from the Longevity check-up (Lookup) 7+ project. Lookup 7+ is an ongoing cross-sectional survey conducted in unconventional settings across Italy. People who are at least 18-year-old and provide written informed consent are eligible. CHMs [i.e., smoking status, healthy diet, body mass index (BMI), blood pressure, blood cholesterol, and diabetes status] are assessed through closed questions and objective measurements. Physical performance is measured via the 5-repetition chair-stand test. Analyses included 7446 participants (55.5 \ub1 14.9 years; 56% women). Physical performance positively correlated with CHMs scores, such that participants who scored higher (6\u20137 points) completed the chair-stand test about 2 s faster than those scoring lower (1\u20132 points). In fully adjusted analysis, better physical performance was more frequently observed in younger, non-smoking, physically active men, with ideal BMI, and no diabetes. Our findings indicate a gradient of better physical function with increasing CHMs scores. Future investigations should establish the longitudinal effect of unhealthy behaviours and cardiovascular risk factors on physical performance and verify whether implementation of large-scale primordial cardiovascular prevention may positively impact physical fitness

Molecular Characterization of the Gastrula in the Turtle Emys orbicularis: An Evolutionary Perspective on Gastrulation

Due to the presence of a blastopore as in amphibians, the turtle has been suggested to exemplify a transition form from an amphibian- to an avian-type gastrulation pattern. In order to test this hypothesis and gain insight into the emergence of the unique characteristics of amniotes during gastrulation, we have performed the first molecular characterization of the gastrula in a reptile, the turtle Emys orbicularis. The study of Brachyury, Lim1, Otx2 and Otx5 expression patterns points to a highly conserved dynamic of expression with amniote model organisms and makes it possible to identify the site of mesoderm internalization, which is a long-standing issue in reptiles. Analysis of Brachyury expression also highlights the presence of two distinct phases, less easily recognizable in model organisms and respectively characterized by an early ring-shaped and a later bilateral symmetrical territory. Systematic comparisons with tetrapod model organisms lead to new insights into the relationships of the blastopore/blastoporal plate system shared by all reptiles, with the blastopore of amphibians and the primitive streak of birds and mammals. The biphasic Brachyury expression pattern is also consistent with recent models of emergence of bilateral symmetry, which raises the question of its evolutionary significance

jFuzzyLogic: a Java Library to Design Fuzzy Logic Controllers According to the Standard for Fuzzy Control Programming

Fuzzy Logic Controllers are a specific model of Fuzzy Rule Based Systems suitable for engineering applications for which classic control strategies do not achieve good results or for when it is too difficult to obtain a mathematical model. Recently, the International Electrotechnical Commission has published a standard for fuzzy control programming in part 7 of the IEC 61131 norm in order to offer a well defined common understanding of the basic means with which to integrate fuzzy control applications in control systems. In this paper, we introduce an open source Java library called jFuzzyLogic which offers a fully functional and complete implementation of a fuzzy inference system according to this standard, providing a programming interface and Eclipse plugin to easily write and test code for fuzzy control applications. A case study is given to illustrate the use of jFuzzyLogic.McGill Uninversity, Genome QuebecSpanish Government TIN2011-28488Andalusian Government P10-TIC-685

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.

Background -Preeclampsia (PE) is a complex and common human-specific pregnancy syndrome associated with placental pathology. The human-specificity provides both intellectual and methodological challenges, lacking a robust model system. Given the role of imprinted genes in human placentation and the vulnerability of imprinted genes to loss of imprinting changes, there has been extensive speculation, but no robust evidence, that imprinted genes are involved in PE. Our study aims at investigating whether disturbed imprinting contributes to PE. Methods -We first aimed at confirming that PE is a disease of the placenta by generating and analysing genome-wide molecular data on well-characterized patient material. We performed high-throughput transcriptome analyses of multiple placenta samples from normal and PE patients. Next, we identified differentially expressed genes (DEGs) in PE placenta, and intersected them with the list of human imprinted genes. We employed bioinformatics/statistical analyses to confirm association between imprinting and PE, and to predict biological processes affected in PE. Validation included epigenetic and cellular assays. Regarding human-specificity, we established an in vitro invasion-differentiation trophoblast model. Our comparative phylogenetic analysis involved single-cell transcriptome data of human, macaque and mouse preimplantation embryogenesis. Results -We found disturbed placental imprinting in PE and revealed potential candidates, including GATA3 and DLX5, with poorly explored imprinted status and no prior association with PE. Due to loss of imprinting DLX5 was upregulated in 69% of PE placentas. Levels of DLX5 correlated with classical PE marker. DLX5 is expressed in human, but not in murine trophoblast. The DLX5(high) phenotype resulted in reduced proliferation, increased metabolism and ER stress-response activation in trophoblasts in vitro The transcriptional profile of such cells mimics the transcriptome of PE placentas. Pan-mammalian comparative analysis identified DLX5 as a part of the human-specific regulatory network of trophoblast differentiation. Conclusions -Our analysis provides evidence of a true association between disturbed imprinting, gene expression and PE. Due to disturbed imprinting, the upregulated DLX5 affects trophoblast proliferation. Our in vitro model might fill a vital niche in PE research. Human-specific regulatory circuitry of DLX5 might help to explain certain aspects of PE

Evolutionary multi-objective training set selection of data instances and augmentations for vocal detection

© Springer Nature Switzerland AG 2019. The size of publicly available music data sets has grown significantly in recent years, which allows training better classification models. However, training on large data sets is time-intensive and cumbersome, and some training instances might be unrepresentative and thus hurt classification performance regardless of the used model. On the other hand, it is often beneficial to extend the original training data with augmentations, but only if they are carefully chosen. Therefore, identifying a “smart” selection of training instances should improve performance. In this paper, we introduce a novel, multi-objective framework for training set selection with the target to simultaneously minimise the number of training instances and the classification error. Experimentally, we apply our method to vocal activity detection on a multi-track database extended with various audio augmentations for accompaniment and vocals. Results show that our approach is very effective at reducing classification error on a separate validation set, and that the resulting training set selections either reduce classification error or require only a small fraction of training instances for comparable performance