261 research outputs found
Strong Pinning and Plastic Deformations of the Vortex Lattice
We investigate numerically the dynamically generated plastic deformations of
a 3D vortex lattice (VL) driven through a disorder potential with isolated,
strong pinning centers (point-like or extended along the field direction). We
find that the VL exhibits a very peculiar dynamical behavior in the plastic
flow regime, in particular, topological excitations consisting of three or four
entangled vortices are formed. We determine the critical current density
and the activation energy for depinning in the presence of a finite
density of strong pinning centers.Comment: 12 pages, TeX type, Postscript figure
Effect of electron irradiation on vortex dynamics in YBa_2Cu_3O_{7-x} single crystals
We report on drastic change of vortex dynamics with increase of quenched
disorder: for rather weak disorder we found a single vortex creep regime, which
we attribute to a Bragg-glass phase, while for enhanced disorder we found an
increase of both the depinning current and activation energy with magnetic
field, which we attribute to entangled vortex phase. We also found that
introduction of additional defects always increases the depinning current, but
it increases activation energy only for elastic vortex creep, while it
decreases activation energy for plastic vortex creep.Comment: 4 pages, 3 figures, submited to Phys. Rev.
Dynamics of Flux Creep in Underdoped Single Crystals of Y_1-xPr_xBa_2Cu_3O_7-d
Transport as well as magnetic relaxation properties of the mixed state were
studied on strongly underdoped Y_1-xPr_xBa_2Cu_3O_7-d crystals. We observed two
correlated phenomena - a coupling transition and a transition to quantum creep.
The distribution of transport current below the coupling transition is highly
nonuniform, which facilitates quantum creep. We speculate that in the mixed
state below the coupling transition, where dissipation is nonohmic, the current
distribution may be unstable with respect to self-channeling resulting in the
formation of very thin current-carrying layers.Comment: 11 pages, 9 figures, Submitted to Phys. Rev.
Plasticity and memory effects in the vortex solid phase of twinned YBa2Cu3O7 single crystals
We report on marked memory effects in the vortex system of twinned YBa2Cu3O7
single crystals observed in ac susceptibility measurements. We show that the
vortex system can be trapped in different metastable states with variable
degree of order arising in response to different system histories. The pressure
exerted by the oscillating ac field assists the vortex system in ordering,
locally reducing the critical current density in the penetrated outer zone of
the sample. The robustness of the ordered and disordered states together with
the spatial profile of the critical current density lead to the observed memory
effects
Pinning-induced transition to disordered vortex phase in layered superconductors
Destruction of the vortex lattice by random point pinning is considered as a
mechanism of the ``second peak'' transition observed experimentally in weakly
coupled layered high temperature superconductors. The transition field
separating the topologically ordered quasilattice from the amorphous vortex
configuration is strongly influenced by the layered structure and by the
nonlocal nature of the vortex tilt energy due to the magnetic interlayer
coupling. We found three different regimes of transition depending on the
relative strength of the Josephson and magnetic couplings. The regimes can be
distinguished by the dependence of the transition fieldComment: 8 pages, 3 Postscript figures. Accepted to Phys. Rev.B. (regular
article
Self-organization of vortices in type-II superconductors during magnetic relaxation
We revise the applicability of the theory of self-organized criticality (SOC)
to the process of magnetic relaxation in type-II superconductors. The driving
parameter of self-organization of vortices is the energy barrier for flux creep
and not the current density. The power spectrum of the magnetic noise due to
vortex avalanches is calculated and is predicted to vary with time during
relaxation.Comment: RevTex, 5 pages, 2 PS figures. Accepted in Phys. Rev.
Hysteretic behavior of the vortex lattice at the onset of the second peak for HgBaCuO superconductor
By means of local Hall probe ac and dc permeability measurements we
investigated the phase diagram of vortex matter for the HgBaCuO superconductor in the regime near the critical temperature. The second peak
line, , in contrast to what is usually assumed, doesn't terminate
at the critical temperature. Our local ac permeability measurements revealed
pronounced hysteretic behavior and thermomagnetic history effects near the
onset of the second peak, giving evidence for a phase transition of vortex
matter from an ordered qausilattice state to a disordered glass
Mixed origin of neovascularization of human endometrial grafts in immunodeficient mouse models
peer reviewedBACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and pathology, the origin of neovasculature in xenografts remains controversial. The aim of this study was to assess the origin of the neovasculature of endometrial grafts in different mouse models. METHODS: Human proliferative endometrium (n = 19 women) was grafted s.c. in two immunodeficient mouse strains: nude (n = 8) and severely compromised immunodeficient (SCID; n = 20). Mice were also treated with estradiol, progesterone or levonorgestrel. Fluorescence in-situ hybridization using a centromeric human chromosome X probe, immunohistochemistry (von Willebrand factor and collagen IV) and lectin perfusion were performed to identify the origin of the vessels. RESULTS: More than 90% of vessels within xenografts were of human origin 4 weeks after implantation. Some vessels (9.67 +/- 2.01%) were successively stained by human or mouse specific markers, suggesting the presence of chimeric vessels exhibiting a succession of human and murine portions. No difference in staining was observed between the two strains of mouse or different hormone treatments. Furthermore, erythrocytes were found inside human vessels, confirming their functionality. CONCLUSION: This article shows that human endometrial grafts retain their own vessels, which connect to the murine vasculature coming from the host tissue and become functional
Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer
Angiogenesis is critical for the growth and metastasis of endometrial cancer and is therefore an important therapeutic target. Vascular endothelial growth factor-A (VEGF-A) is a key molecule in angiogenesis, but the identification of related molecules and the angiopoietins suggests a more complex picture. We investigated the presence of transcripts for VEGF-A, VEGF-B, VEGF-C, VEGF-D, Angiopoietin-1 and Angiopoietin-2 in benign endometrium, atypical complex hyperplasia (ACH) and endometrioid endometrial carcinoma using in situ hybridisation. We confirmed the presence of VEGF-A mRNA in the epithelial cells of cancers examined (13 out of 13), but not in benign endometrium or ACH. We also demonstrate, using quantitative polymerase chain reaction, that levels of VEGF-B mRNA are significantly lower in endometrial cancer than benign endometrium. We conclude that loss of VEGF-B may contribute to the development of endometrial carcinoma by modulating availability of receptors for VEGF-A
Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of NOD mice to an inducer of accelerated diabetes
One's present repertoire of antibodies encodes the history of one's past
immunological experience. Can the present autoantibody repertoire be consulted
to predict resistance or susceptibility to the future development of an
autoimmune disease? Here we developed an antigen microarray chip and used
bioinformatic analysis to study a model of type 1 diabetes developing in
non-obese diabetic (NOD) male mice in which the disease was accelerated and
synchronized by exposing the mice to cyclophosphamide at 4 weeks of age. We
obtained sera from 19 individual mice, treated the mice to induce
cyclophosphamide-accelerated diabetes (CAD), and found, as expected, that 9
mice became severely diabetic while 10 mice permanently resisted diabetes. We
again obtained serum from each mouse afterCAD induction. We then analyzed the
patterns of antibodies in the individualmice to 266 different antigens spotted
on the antigen chip. We identified a select panel of 27 different antigens (10%
of the array) that revealed a pattern of IgG antibody reactivity in the pre-CAD
serathat discriminated between the mice resistant or susceptible to CAD with
100% sensitivity and 82% specificity (p=0.017). Surprisingly, the set of IgG
antibodies that was informative before CAD induction did not separate the
resistant and susceptible groups after the onset of CAD; new antigens became
criticalfor post-CAD repertoire discrimination. Thus, at least for a model
disease, present antibody repertoires can predict future disease; predictive
and diagnostic repertoires can differ; and decisive information about immune
system behavior can be mined by bioinformatic technology. Repertoires matter.Comment: See Advanced Publication on the PNAS website for final versio
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