1,058 research outputs found
Neuroimaging Findings in Paediatric Patients with Sickle Cell Disease
Sickle cell disease (SCD) is an autosomal recessive haemoglobinopathy, which manifests as multisystem ischaemia and infarction, as well as haemolytic anaemia. The morphological changes of red blood cells (RBCs) that promote ischaemia/infarction as the main multi-systemic manifestation, with associated vasculopathy, may also lead to haemorrhage and fat embolisation. Bone infarctions, whether of the skull or spine, are relatively common with subsequent increased infectious susceptibility. We present a broad spectrum of brain and spine imaging findings of SCD from a level III paediatric hospital in Lisbon, between 2010 and 2022. Our aim is to highlight brain and spine imaging findings from a serial review of multiple patients with SCD and respective neuroimaging characterisation.info:eu-repo/semantics/publishedVersio
Region of hadron-quark mixed phase in hybrid stars
Hadron--quark mixed phase is expected in a wide region of the inner structure
of hybrid stars. However, we show that the hadron--quark mixed phase should be
restricted to a narrower region to because of the charge screening effect. The
narrow region of the mixed phase seems to explain physical phenomena of neutron
stars such as the strong magnetic field and glitch phenomena, and it would give
a new cooling curve for the neutron star.Comment: to be published in Physical Review
Implications of early selection for resistance to anthracnose in genetic breeding of common bean
Phenomenology of event shapes at hadron colliders
We present results for matched distributions of a range of dijet event shapes
at hadron colliders, combining next-to-leading logarithmic (NLL) accuracy in
the resummation exponent, next-to-next-to leading logarithmic (NNLL) accuracy
in its expansion and next-to-leading order (NLO) accuracy in a pure alpha_s
expansion. This is the first time that such a matching has been carried out for
hadronic final-state observables at hadron colliders. We compare our results to
Monte Carlo predictions, with and without matching to multi-parton tree-level
fixed-order calculations. These studies suggest that hadron-collider event
shapes have significant scope for constraining both perturbative and
non-perturbative aspects of hadron-collider QCD. The differences between
various calculational methods also highlight the limits of relying on
simultaneous variations of renormalisation and factorisation scale in making
reliable estimates of uncertainties in QCD predictions. We also discuss the
sensitivity of event shapes to the topology of multi-jet events, which are
expected to appear in many New Physics scenarios.Comment: 70 pages, 25 figures, additional material available from
http://www.lpthe.jussieu.fr/~salam/pp-event-shapes
The moderating effect of gender on the relationship between coping and suicide risk in a Portuguese community sample of adults
Neutron Majorana mass from exotic instantons
We show how a Majorana mass for the Neutron could result from
non-perturbative quantum gravity effects peculiar to string theory. In
particular, "exotic instantons" in un-oriented string compactifications with
D-branes extending the (supersymmetric) standard model could indirectly produce
an effective operator delta{m} n^t n+h.c. In a specific model with an extra
vector-like pair of `quarks', acquiring a large mass proportional to the string
mass scale (exponentially suppressed by a function of the string moduli
fields), delta{m} can turn out to be as low as 10^{-24}-10^{-25} eV. The
induced neutron-antineutron oscillations could take place with a time scale
tau_{n\bar{n}} > 10^8 s, that could be tested by the next generation of
experiments. On the other hand, proton decay and FCNC's are automatically
strongly suppressed and are compatible with the current experimental limits.
Depending on the number of brane intersections, the model may also lead to the
generation of Majorana masses for R-handed neutrini. Our proposal could also
suggest neutron-neutralino or neutron-axino oscillations, with implications in
UCN, Dark Matter Direct Detection, UHECR and Neutron-Antineutron oscillations.
This suggests to improve the limits on neutron-antineutron oscillations, as a
possible test of string theory and quantum gravity.Comment: 35 pages, 11 figures. More comments on neutron-neutralino mixin
Genetic Characterization of Human T-Cell Lymphotropic Virus Type 1 in Mozambique: Transcontinental Lineages Drive the HTLV-1 Endemic
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of Adult T-Cell Leukemia/Lymphoma (ATL), the Tropical Spastic Paraparesis/HTLV-1-associated Myelopathy (TSP/HAM) and other inflammatory diseases, including dermatitis, uveitis, and myositis. It is estimated that 2–8% of the infected persons will develop a HTLV-1-associated disease during their lifetimes, frequently TSP/HAM. Thus far, there is not a specific treatment to this progressive and chronic disease. HTLV-1 has means of three transmission: (i) from mother to child during prolonged breastfeeding, (ii) between sexual partners and (iii) through blood transfusion. HTLV-1 has been characterized in 7 subtypes and the geographical distribution and the clinical impact of this infection is not well known, mainly in African population. HTLV-1 is endemic in sub-Saharan Africa. Mozambique is a country of southeastern Africa where TSP/HAM cases were reported. Recently, our group estimated the HTLV prevalence among Mozambican blood donors as 0.9%. In this work we performed a genetic analysis of HTLV-1 in blood donors and HIV/HTLV co-infected patients from Maputo, Mozambique. Our results showed the presence of three HTLV-1 clusters within the Cosmopolitan/Transcontinental subtype/subgroup. The differential rates of HIV-1/HTLV-1 co-infection in the three HTLV-1 clusters demonstrated the dynamic of the two viruses and the need for implementation of control measures focusing on both retroviruses
Impact of Malocclusion on Oral Health-Related Quality of Life of 8-12 Years Old Schoolchildren in Southern Brazil
Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma.
The aim of this study was to search for bioactive natural products from medicinal plants targeting vasorelaxant activity and we found the methanol extract from bark of Tabernaemontana dichotoma showed vasorelaxant activity on rat aorta. We isolated eight indole alkaloids including 10-methoxyalstonerine (1), a new macroline type indole alkaloid, from bark of T. dichotoma. These were respectively identified as 10-methoxyaffinisine (2), lochnerine (3), cathafoline (4), (−)-alstonerine (5), 19,20-dehydro-10-methoxytalcarpine (6), alstonisine (7), and alstonal (8) based on spectroscopic analysis. Among them, sarpagine type (2 and 3), akuammiline type (4), and macroline oxindole type (7 and 8) showed potent vasorelaxant activity. Mechanism of action on vasorelaxant activity of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) was clarified. Effects of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) were partially mediated the NO release from endothelial cells. Furthermore, 10-methoxyaffinisine (2) and alstonisine (7) attribute to the inhibitory effect of VDC and ROC, and cathafoline (4) have inhibitory effect on Ca2+ influx via ROC. In addition, 10-methoxyaffinisine (2) as a major compound from bark of T. dichotoma showed hypotensive effect on normotensive rats in vivo
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