Tushaar Shah. Catalysing Co-operation: Design of Self-governing Organisations. New Delhi: Sage Publications, 1996. 315 pages. Hardbound. Indian Rs 295.00.

Within the different types of organisational structures available, it is generally believed that co-operative organisations serve the poor better than the other available alternatives. This belief is based on the fact that these organisations are usually owned and controlled by the people and their objective is to provide services instead of making profits. They are, therefore, considered an important instrument for equitable development, and have been given a prominent role in the national development strategies in many developing countries. It is surprising, however, that the performance of cooperatives is not as satisfactory as it could have been. They have met with only occasional success in Asia. This book explores the causes of this failure

Carotenoid Extraction from Locally and Organically Produced Cereals Using Saponification Method

Carotenoids are important phytochemicals contributing nutritional health benefits in the human diet, with a significant contribution from cereals as one of the major food component around the world. Different methods have been described and adopted for the extraction and isolation of carotenoid compounds. Saponification can be seen as an option for carotenoid extraction from cereals as it converts retinol esters to retinol and removes other abundant compounds such as triglycerides. Extraction of carotenoids content of locally adapted and organic cereals have been limitedly investigated and was, therefore, evaluated in the present study, with a specific aim to understand genotypic and local cultivation effects and interactions. Therefore, 17 diverse cereal genotypes of local origin were grown organically in four localities and evaluated for carotenoid content and composition by HPLC. The results showed a large variation in content and composition of carotenoids in locally adapted and organically grown cereal genotypes, with lutein as the dominating type in wheat and rye, while zeaxanthin was the dominating type in barley. High-level genotypes showed values (9.9 mg/kg of total carotenoids) similar to the highest values previously reported in specific types of wheat. The barley genotypes showed relatively high stability in carotenoids content within and between cultivation locations, while large interactions were found with the cultivation location for the rest of the genotypes, indicating their local adaptation. The local adaptation of the cereal genotypes evaluated contributes large opportunities for local production of high value, highly nutritious food products, while the direct value of these genotypes for conventional plant breeding for varieties performing similar over broad environmental ranges, are more limited

Hepatitis G Virus associated aplastic anemia: A recent case from Pakistan

<p>Abstract</p> <p>Background</p> <p>Aplastic anemia (AA) is a serious and rare disorder characterized by a hypocellular bone marrow. Hepatitis associated aplastic anemia (HAAA) is a variant of aplastic anemia in which aplastic anemia follows an acute attack of hepatitis. Several reports have noted an association between HGV and hepatitis-associated aplastic anemia besides other hepatitis causing viruses.</p> <p>Case presentation</p> <p>A female girl of age 11 year with a history of loose motion for one month, vomiting for last 15 days and poor oral intake for last few days is reported here. The physical examination presents fever, pallor whereas bleeding, hepatomegaly, Splenomegaly and bruising were absent, abdominal ultrasonography confirmed the absence of hepatomegaly, Splenomegaly and lymphodenopathy. The laboratory investigation parameters were: haemoglobin 6.2 g/L, total leucocytes count 1.51, neutrophils 0.47%, absolute reticulocyte count 0.5%, Monocytes 0.16%, red cell count 3.2 mil/uL, Picked cell volume (PCV) 30.13%, Mean Corpuscular Volume (MCV) 78 fL, Mean Corpuscular Hemoglobin (MCH) 26.3 pg. The liver enzymes were alanine aminotransferease (ALT) 98 IU/L, aspartate aminotransferase (AST) 114 IU/L. Serologic and molecular tests for hepatitis A, B, C, D, E, TTV, B19 were negative, whereas HGV RNA PCR test was found positive for hepatitis G virus. The bone marrow aspirate and trephine biopsy examination revealed hypo- cellularity, erythropoiesis, myelopoiesis and megakaryopoiesis.</p> <p>Conclusion</p> <p>HAAA is an uncommon but severe condition, which may occur following idiopathic cases of acute hepatitis. Our finding suggests the involvement of HGV in the development of aplastic anemia. In patients presenting with pancytopenia after an episode of acute hepatitis, the definitive diagnosis should be considered and confirmed by RT-PCR and if possible by bone marrow biopsy.</p

A new approach to fuzzy control using distending function

The paper presents a novel design for fuzzy logic control using the Distending Function (DF) as a membership function. The proposed design is close to human input and can be transformed into fuzzy model for stability analysis using conventional control theory. The design procedure is simplified by employing fuzzy arithmetic and properties of this new type of membership function. Its compatible with the existing operators system and can be used with already developed fuzzy models to achieve greater flexibility in design process.The effectiveness of the proposed methodology is demonstrated by designing tracking fuzzy controllers for vehicle lateral dynamics and water tank systems

An efficient weighted network centrality approach for exploring mechanisms of action of the Ruellia herbal formula for treating rheumatoid arthritis

Aim This study outlines an efficient weighted network centrality measure approach and its application in network pharmacology for exploring mechanisms of action of the Ruellia prostrata (RP) and Ruellia bignoniiflora (RB) herbal formula for treating rheumatoid arthritis. Method In our proposed method we first calculated interconnectivity scores all the network targets then computed weighted centrality score for all targets to identify of major network targets based on centrality score. We apply our technology to network pharmacology by constructing herb-compound-putative target network; compound-putative targets-RA target network; and imbalance multi-level herb-compound-putative target-RA target-PPI network. We then identify the major targets in the network based on our centrality measure approach. Finally we validated the major identified network targets using the enrichment analysis and a molecular docking simulation. Result The results reveled our proposed weighted network centrality approach outperform classical centrality measure in identification of influential nodes in four real complex networks based on SI model simulation. Application of our approach to network pharmacology shows that 57 major targets of which 33 targets including 8 compositive compounds, 15 putative target and 10 therapeutic targets played an important role in the network and directly linked to rheumatoid arthritis. Enrichment analysis confirmed that putative targets were frequently involved in TNF, CCR5, IL-17 and G-protein coupled receptors signaling pathways which are critical in the progression of rheumatoid arthritis. The molecular docking simulation indicated four targets had significant binding affinity to major protein targets. Glyceryl diacetate-2-Oleate and Oleoyl chloride showed the best binding affinity to all targets proteins and were within Lipinski limits. ADMET prediction also confirm both compounds had no toxic effect on human hence potential lead drug compounds for treating rheumatoid arthritis. Conclusion This study developed an efficient weighted network centrality approach as tool for identification of major network targets. Network pharmacology findings provides promising results that could lead us to design and discover of alternative drug compounds. Though our approach is a purely in silico method, clinical experiments are required to test and validate the hypotheses of our computational methods

Economic Determinants of Non-Performing Loans: Perception of Pakistani Bankers

This study provides the perception of Pakistani bankers regarding the economic factors causing non-performing loans in the Pakistani banking sector since 2006. This is the first time that any study is conducted in Pakistan to highlight the economic factors of NPLs via primary data collection from loan providing and approving authorities of Pakistani banking industry. This study was conducted via a well structured questionnaire and data was collected from 201 bankers who are involved in the lending decisions or analyze the credit risk or handling non-performing loans portfolio. Correlation and regression analysis was carried out to analyze the impact of selected independent variables (Interest Rate, Energy Crisis, Unemployment, Inflation, GDP Growth, and Exchange Rate) on the non-performing loans of Pakistani banking sector. Top 10 Pakistani banks were selected as a sample. According to the results Pakistani bankers perceive that Interest Rate, Energy Crisis, Unemployment, Inflation, and Exchange Rate has a significant positive relationship with the non-performing loans of Pakistani banking sector while GDP growth has significant negative relationship with the non-performing loans of Pakistani banking sector. This study also discusses how good loans are turning into bad loans due to disaster in energy sector of Pakistan and how these energy crisis are badly affecting the banking sector of Pakistan. In future social determinants of non-performing loans should be studied. This study is first of its kind opening door for further primary research on NPLS of Pakistani banking sector. Key words: Non-performing loan; perception of Pakistani bankers; energy crisis; Economic determinants of Non-performing loan