The Location and Appearance of Second Malignancies in Patients With Bilateral Retinoblastoma

Purpose. This paper describes the clinical history and radiographic appearance of second malignancies in patients with bilateral retinoblastoma

Fluid physics, thermodynamics, and heat transfer experiments in space

An overstudy committee was formed to study and recommend fundamental experiments in fluid physics, thermodynamics, and heat transfer for experimentation in orbit, using the space shuttle system and a space laboratory. The space environment, particularly the low-gravity condition, is an indispensable requirement for all the recommended experiments. The experiments fell broadly into five groups: critical-point thermophysical phenomena, fluid surface dynamics and capillarity, convection at reduced gravity, non-heated multiphase mixtures, and multiphase heat transfer. The Committee attempted to assess the effects of g-jitter and other perturbations of the gravitational field on the conduct of the experiments. A series of ground-based experiments are recommended to define some of the phenomena and to develop reliable instrumentation

Multi-objective engineering shape optimization using differential evolution interfaced to the Nimrod/O tool

This paper presents an enhancement of the Nimrod/O optimization tool by interfacing DEMO, an external multiobjective optimization algorithm. DEMO is a variant of differential evolution – an algorithm that has attained much popularity in the research community, and this work represents the first time that true multiobjective optimizations have been performed with Nimrod/O. A modification to the DEMO code enables multiple objectives to be evaluated concurrently. With Nimrod/O’s support for parallelism, this can reduce the wall-clock time significantly for compute intensive objective function evaluations. We describe the usage and implementation of the interface and present two optimizations. The first is a two objective mathematical function in which the Pareto front is successfully found after only 30 generations. The second test case is the three-objective shape optimization of a rib-reinforced wall bracket using the Finite Element software, Code_Aster. The interfacing of the already successful packages of Nimrod/O and DEMO yields a solution that we believe can benefit a wide community, both industrial and academic

Testing for a Random Walk Structure in the Frequency Evolution of a Tone in Noise

Inference and hypothesis testing is constructed on the basis that a specific model holds for the data. To determine the veracity of conclusions drawn from such data analyses, one must be able to identify the presence of the assumed structure within the data. A model verification test is developed for the presence of a random walk-like structure for variations in the frequency of complex-valued sinusoidal signals measured in additive Gaussian noise. This test evaluates the joint inference of the random walk hypothesis tests found in economics literature that seek random walk behaviours in time series data, with an additional test to account for how the random walk behaves in frequency space.Comment: 11 pages, 13 figure

Space construction system analysis. Part 2: Platform definition

The top level system requirements are summarized and the accompanying conceptual design for an engineering and technology verification platform (ETVP) system is presented. An encompassing statement of the system objectives which drive the system requirements is presented and the major mission and subsystem requirements are described with emphasis on the advanced communications technology mission payload. The platform design is defined and used as a reference configuration for an end to space construction analyses. The preferred construction methods and processes, the important interactions between the platform design and the construction system design and operation, and the technology development efforts required to support the design and space construction of the ETVP are outlined

The Dependence of Galaxy Shape on Luminosity and Surface Brightness Profile

For a sample of 96,951 galaxies from the Sloan Digital Sky Survey Data Release 3, we study the distribution of apparent axis ratios as a function of r-band absolute magnitude and surface brightness profile type. We use the parameter fracDeV to quantify the profile type (fracDeV = 1 for a de Vaucouleurs profile; fracDeV = 0 for an exponential profile). When the apparent axis ratio q_{am} is estimated from the moments of the light distribution, the roundest galaxies are very bright (M_r \sim -23) de Vaucouleurs galaxies and the flattest are modestly bright (M_r \sim -18) exponential galaxies. When the apparent axis ratio q_{25} is estimated from the axis ratio of the 25 mag/arcsec^2 isophote, we find that de Vaucouleurs galaxies are flatter than exponential galaxies of the same absolute magnitude. For a given surface brightness profile type, very bright galaxies are rounder, on average, than fainter galaxies. We deconvolve the distributions of apparent axis ratios to find the distribution of the intrinsic short-to-long axis ratio gamma, assuming constant triaxiality T. For all profile types and luminosities, the distribution of apparent axis ratios is inconsistent with a population of oblate spheroids, but is usually consistent with a population of prolate spheroids. Bright galaxies with a de Vaucouleurs profile (M_r < -21.84, fracDeV > 0.9) have a distribution of q_{am} that is consistent with triaxiality in the range 0.4 < T < 0.8, with mean intrinsic axis ratio 0.66 < gamma < 0.69. The fainter de Vaucouleurs galaxies are best fit with prolate spheroids (T = 1) with mean axis ratio gamma = 0.51.Comment: 32 pages, 12 figures, to appear in Ap

Periodic organization of the contractile apparatus in smooth muscle revealed by the motion of dense bodies in single cells

To study the organization of the contractile apparatus in smooth muscle and its behavior during shortening, the movement of dense bodies in contracting saponin skinned, isolated cells was analyzed from digital images collected at fixed time intervals. These cells were optically lucent so that punctate structures, identified immunocytochemically as dense bodies, were visible in them with the phase contrast microscope. Methods were adapted and developed to track the bodies and to study their relative motion. Analysis of their tracks or trajectories indicated that the bodies did not move passively as cells shortened and that nearby bodies often had similar patterns of motion. Analysis of the relative motion of the bodies indicated that some bodies were structurally linked to one another or constrained so that the distance between them remained relatively constant during contraction. Such bodies tended to fall into laterally oriented, semirigid groups found at approximately 6-microns intervals along the cell axis. Other dense bodies moved rapidly toward one another axially during contraction. Such bodies were often members of separate semirigid groups. This suggests that the semirigid groups of dense bodies in smooth muscle cells may provide a framework for the attachment of the contractile structures to the cytoskeleton and the cell surface and indicates that smooth muscle may be more well-ordered than previously thought. The methods described here for the analysis of the motion of intracellular structures should be directly applicable to the study of motion in other cell types