Financial Aid and Students' College Decisions: Evidence from the District of Columbia's Tuition Assistance Grant Program

The District of Columbia's Tuition Assistance Grant Program (DCTAG), instituted in 1999, allows DC residents to attend public colleges and universities throughout the country at considerably lower in-state tuition rates. We use the sharp decline in the price of public colleges and universities faced by residents of the District of Columbia under DCTAG to estimate the effects of price on students' college application and enrollment decisions. Using a sample of students from nearby large cities as a control group, we find that the number and share of DC residents applying to four-year colleges increased substantially under the program, and students were considerably more likely to apply to colleges that were eligible for the subsidy. Freshmen enrollments of DC residents also increased substantially at eligible institutions, although the effect on overall freshmen enrollments of DC residents was fairly modest, suggesting that in its first year the subsidy had more of an impact on where students chose to attend than on whether they chose to attend college at all.

Comparing Galactic Center MSSM dark matter solutions to the Reticulum II gamma-ray data

Observations with the Fermi Large Area Telescope (LAT) indicate a possible small photon signal originating from the dwarf galaxy Reticulum II that exceeds the expected background between 2 GeV and 10 GeV. We have investigated two specific scenarios for annihilating WIMP dark matter within the phenomenological Minimal Supersymmetric Standard Model (pMSSM) framework as a possible source for these photons. We find that the same parameter ranges in pMSSM as reported by an earlier paper to be consistent with the Galactic center excess, is also consistent with the excess observed in Reticulum II, resulting in a J-factor of $\log_{10}(J(\alpha_{int}=0.5 deg)) \simeq (20.3-20.5)^{+0.2}_{-0.3}$. This J-factor is consistent with $\log_{10}(J(\alpha_{int}=0.5 deg)) = 19.5^{+1.0}_{-0.6}$ GeV$^2$cm$^{-5}$, which is derived using an optimized spherical Jeans analysis of kinematic data obtained from the Michigan/Magellan Fiber System (M2FS).Comment: 4 pages, 2 figures, accepted in JCA

Evapotranspiration of two vegetation communities in a high-elevation riparian meadow at Hart Prairie, Arizona

Hart Prairie, Arizona, has the largest Bebb willow (Salix bebbiana) community in the United States; however, greater than 95% of willows are older than 80 years and regeneration by seed is not occurring. This study examined the evapotranspiration of two herbaceous communities that dominate the Hart Prairie watershed: (1) a mixture of bracken fern (Pteridium aquilinum) and graminoids and (2) dominantly graminoids. Transpiration during premonsoon and postmonsoon dry periods of 2000, 2001, and 2002 was estimated for each community by the difference in volumetric soil-water content (0-30 cm soil depth) between replicated plots that were clipped of all vegetation and control, unclipped plots. Transpiration rates estimated under conditions of minimal soil drainage varied between 0.63 and 2.4 mm/d for the fern-graminoid community and 0.57 and 1.1 mm/d for the graminoid community over the study. The fern-graminoid community produced more biomass than the graminoid community in all years, but generally had lower transpiration rates. Severe drought in year 2002 reduced growth and transpiration of the fern-graminoid community more than the graminoid community. Evaporation rates were estimated by temporal changes in soil-water content in clipped plots during dry periods, and were 54 to 474% of transpiration rates estimated under conditions of minimal soil drainage because of the dry and windy conditions that occur at the study site. Based on this study and a study of transpiration of scattered trees invading the meadow, transpiration by the herbaceous understorey was higher than transpiration by trees during similar seasons

Property Rights and Social Norms for Managing the Commons

In many of the developing countries, dependency on natural resources is significantly high. From peasants to fishermen and farmers, all of them earn their living from the utility of renewable natural resources such as water, air, farming land, forest, plants, animals and grazing areas (Heltberg, 2002). Given the importance of natural resources for many of the developing countries, it is important to address the issues like the tragedy of the commons, climatic change, pollution, and unsustainable usage of natural resources which might lead to rural poverty, food insecurity, and high rural-urban migration (Heltberg, 2002). Among the major factors mentioned above, this essay will focus on tragedy of the commons, property rights, and natural resource management in developing countries

Behavioral mechanisms that mediate mental and physical health improvements in people with chronic pain who receive a digital health intervention: Prospective cohort pilot study

BACKGROUND: Preliminary evidence suggests that digital mental health intervention (Wysa for Chronic Pain) can improve mental and physical health in people with chronic musculoskeletal pain and coexisting symptoms of depression or anxiety. However, the behavioral mechanisms through which this intervention acts are not fully understood. OBJECTIVE: The purpose of this study was to identify behavioral mechanisms that may mediate changes in mental and physical health associated with use of Wysa for Chronic Pain during orthopedic management of chronic musculoskeletal pain. We hypothesized that improved behavioral activation, pain acceptance, and sleep quality mediate improvements in self-reported mental and physical health. METHODS: In this prospective cohort, pilot mediation analysis, adults with chronic (≥3 months) neck or back pain received the Wysa for Chronic Pain digital intervention, which uses a conversational agent and text-based access to human counselors to deliver cognitive behavioral therapy and related therapeutic content. Patient-reported outcomes and proposed mediators were collected at baseline and 1 month. The exposure of interest was participants\u27 engagement (ie, total interactions) with the digital intervention. Proposed mediators were assessed using the Behavioral Activation for Depression Scale-Short Form, Chronic Pain Acceptance Questionnaire, and Athens Insomnia Scale. Outcomes included Patient-Reported Outcomes Measurement Information System Anxiety, Depression, Pain Interference, and Physical Function scores. A mediation analysis was conducted using the Baron and Kenny method, adjusting for age, sex, and baseline mediators and outcome values. P\u3c.20 was considered significant for this pilot study. RESULTS: Among 30 patients (mean age 59, SD 14, years; 21 [70%] female), the mediation effect of behavioral activation on the relationship between increased intervention engagement and improved anxiety symptoms met predefined statistical significance thresholds (indirect effect -0.4, 80% CI -0.7 to -0.1; P=.13, 45% of the total effect). The direction of mediation effect was generally consistent with our hypothesis for all other proposed mediator or outcome relationships, as well. CONCLUSIONS: In a full-sized randomized controlled trial of patients with chronic musculoskeletal pain, behavioral activation, pain acceptance, and sleep quality may play an important role in mediating the relationship between use of a digital mental health intervention (Wysa for Chronic Pain) and improved mental and physical health. TRIAL REGISTRATION: ClinicalTrials.gov NCT05194722; https://clinicaltrials.gov/ct2/show/NCT05194722

Propuesta de mejora del sistema de gestión administrativa de la clínica Odontoláser E.I.R.L sede Primavera 2016

El autor no autoriza la publicación de la tesi

Multi-stakeholder perspectives regarding preferred modalities for mental health intervention delivered in the orthopedic clinic: A qualitative analysis

BACKGROUND: Although depressive and anxious symptoms negatively impact musculoskeletal health and orthopedic outcomes, a gap remains in identifying modalities through which mental health intervention can realistically be delivered during orthopedic care. The purpose of this study was to understand orthopedic stakeholders\u27 perceptions regarding the feasibility, acceptability, and usability of digital, printed, and in-person intervention modalities to address mental health as part of orthopedic care. METHODS: This single-center, qualitative study was conducted within a tertiary care orthopedic department. Semi-structured interviews were conducted between January and May 2022. Two stakeholder groups were interviewed using a purposive sampling approach until thematic saturation was reached. The first group included adult orthopedic patients who presented for management of ≥ 3 months of neck or back pain. The second group included early, mid, and late career orthopedic clinicians and support staff members. Stakeholders\u27 interview responses were analyzed using deductive and inductive coding approaches followed by thematic analysis. Patients also performed usability testing of one digital and one printed mental health intervention. RESULTS: Patients included 30 adults out of 85 approached (mean (SD) age 59 [14] years, 21 (70%) women, 12 (40%) non-White). Clinical team stakeholders included 22 orthopedic clinicians and support staff members out of 25 approached (11 (50%) women, 6 (27%) non-White). Clinical team members perceived a digital mental health intervention to be feasible and scalable to implement, and many patients appreciated that the digital modality offered privacy, immediate access to resources, and the ability to engage during non-business hours. However, stakeholders also expressed that a printed mental health resource is still necessary to meet the needs of patients who prefer and/or can only engage with tangible, rather than digital, mental health resources. Many clinical team members expressed skepticism regarding the current feasibility of scalably incorporating in-person support from a mental health specialist into orthopedic care. CONCLUSIONS: Although digital intervention offers implementation-related advantages over printed and in-person mental health interventions, a subset of often underserved patients will not currently be reached using exclusively digital intervention. Future research should work to identify combinations of effective mental health interventions that provide equitable access for orthopedic patients. TRIAL REGISTRATION: Not applicable

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading to systemic inflammation. Here, we encapsulated cdGMP within PEGylated lipid nanoparticles (NP-cdGMP) to redirect this adjuvant to dLNs. Compared with unformulated CDNs, encapsulation blocked systemic dissemination and markedly enhanced dLN accumulation in murine models. Delivery of NP-cdGMP increased CD8[superscript +] T cell responses primed by peptide vaccines and enhanced therapeutic antitumor immunity. A combination of a poorly immunogenic liposomal HIV gp41 peptide antigen and NP-cdGMP robustly induced type I IFN in dLNs, induced a greater expansion of vaccine-specific CD4[superscript +] T cells, and greatly increased germinal center B cell differentiation in dLNs compared with a combination of liposomal HIV gp41 and soluble CDN. Further, NP-cdGMP promoted durable antibody titers that were substantially higher than those promoted by the well-studied TLR agonist monophosphoryl lipid A and comparable to a much larger dose of unformulated cdGMP, without the systemic toxicity of the latter. These results demonstrate that nanoparticulate delivery safely targets CDNs to the dLNs and enhances the efficacy of this adjuvant. Moreover, this approach can be broadly applied to other small-molecule immunomodulators of interest for vaccines and immunotherapy.Bill & Melinda Gates FoundationRagon Institute of MGH, MIT and HarvardNational Institutes of Health (U.S.) (AI091693)National Institutes of Health (U.S.) (AI095109)National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award 1F32CA180586)Hertz Foundation (Graduate Fellowship)National Science Foundation (U.S.). Graduate Research Fellowshi

Análisis turístico basado en las fortalezas y debilidades intrínsecas del territorio

This study focuses on five parishes in the Zaruma canton, with the aim of determining the main strengths or weaknesses that promote or hinder tourism in the sector. The analysis is based on the guidelines of the Methodological Guide for the ranking of attractions and generation of tourist spaces in Ecuador. The first stage was used with its two initial phases, and to facilitate the analysis of the criteria, a weighted percentage was applied to the evaluation criteria, in order to make statistical graphs of the attractions, which allowed us to identify that the tourism potential lies in the cultural-heritage tourism modality and that its complementary attractions, despite having many weaknesses, can be developed with proper management.  La potencialidad turística se basa en los aspectos intrínsecos que posee un recurso o destino del territorio en función de la actividad, para desarrollarlas por medio de una correcta gestión. En este contexto, el presente estudio se enfoca en cinco parroquias del cantón Zaruma, con el objetivo de determinar las principales fortalezas o debilidades que fomentan u obstaculizan el turismo en el sector. El análisis se basa en los lineamientos de la Guía metodología para la jerarquización de atractivos y generación de espacios turísticos del Ecuador. Se empleó la primera etapa con sus dos fases iniciales, y para facilitar el análisis de los criterios, se aplicó un porcentaje de ponderación a los criterios de evaluación para realizar gráficos estadísticos de los atractivos, lo que permitió identificar que el potencial turístico radica en la modalidad turística cultural-patrimonial y que sus atractivos complementarios, a pesar de tener muchas debilidades, pueden ser desarrollados con una gestión adecuada