The problem of off label drug use in pediatrics: pediatricians and parents survey results

LLC Novartis Pharma, Moscow, Russian Federation Abstract. The problem of off-label use is still unsolved during the pharmacotherapy in children. In connection with the above, the need to stimulate the conduct of specially organized clinical studies, the purpose of which will be to evaluate the efficacy and safety of using drugs in children in different age groups, becomes evident. However the complexity of the organization of clinical studies in pediatrics is associated not only with regulatory aspects but also with lack of understanding of the importance of these studies by pediatricians and parents. The authors conducted a study aimed at finding out the frequency of off-label prescriptions in the Russian Federation in pediatric practice and doctors’ and parents’ attitude to this kind of use of medications. The study has shown the evidence that the off-label prescription practice is widely-used in healthcare in Russia and is routine for most respondents. The highest frequency of off-label prescriptions is observed in the group of children from 0 to 5 years. The majority of physicians and parents don’t consider themselves responsible for popularization of clinical trials which indicates that this problem should be widely discussed in the society. Parents trust physicians in terms of therapy choices or their recommendations regarding participation in clinical trials. A portrait of a typical “staunch opponent” of clinical trials among parents

Innovative reference points of the industrial policy in Kazakhstan

The crucial importance of the choice of working out and implementation mechanism of industrial policy system concept in the regional dimension is noted; three models of industrial policy are considered: exportoriented, import substitution and innovative; the strategy of accelerated industrial and innovative development of Kazakhstan is analyzed; the uniqueness of solution to the problem of industrial policy and self-development of business structures interrelation is emphasized

Innovative reference points of the industrial policy in Kazakhstan

The crucial importance of the choice of working out and implementation mechanism of industrial policy system concept in the regional dimension is noted; three models of industrial policy are considered: exportoriented, import substitution and innovative; the strategy of accelerated industrial and innovative development of Kazakhstan is analyzed; the uniqueness of solution to the problem of industrial policy and self-development of business structures interrelation is emphasized.</div

The orbital stability of a test body motion in the field of two massive bodies

We investigate the orbital stability of a test particle motion in the restricted three-body problem where all bodies have their own rotation. We have shown that it is possible to get some insight into the stability properties of the motion of test particles in restricted three-body problem, without knowing the exact solutions of the relativistic motion equations. © The Authors, published by EDP Sciences, 2018

Dilatonic dyon-like black hole solutions in the model with two Abelian gauge fields

Dilatonic black hole dyon-like solutions in the gravitational 4d model with a scalar field, two 2-forms, two dilatonic coupling constants $$\lambda _i \ne 0$$, $$i =1,2$$, obeying $$\lambda _1 \ne - \lambda _2$$ and the sign parameter $$\varepsilon = \pm 1$$ for scalar field kinetic term are considered. Here $$\varepsilon = - 1$$ corresponds to a ghost scalar field. These solutions are defined up to solutions of two master equations for two moduli functions, when $$\lambda ^2_i \ne 1/2$$ for $$\varepsilon = - 1$$. Some physical parameters of the solutions are obtained: gravitational mass, scalar charge, Hawking temperature, black hole area entropy and parametrized post-Newtonian (PPN) parameters $$\beta$$ and $$\gamma$$. The PPN parameters do not depend on the couplings $$\lambda _i$$ and $$\varepsilon$$. A set of bounds on the gravitational mass and scalar charge are found by using a certain conjecture on the parameters of solutions, when $$1 +2 \lambda _i^2 \varepsilon > 0$$, $$i =1,2$$

Dilatonic dyon black hole solutions in the model with two Abelian gauge fields

Dilatonic black hole dyon-like solutions in the gravitational 4d model with a scalar field, two 2-forms, two dilatonic coupling constants λi = 0, i = 1,2, obeying λ1 = - λ2 and sign parameter ϵ = ±1 for scalar field kinetic term are considered. Here ϵ = -1 corresponds to ghost scalar field. These solutions are defined up to solutions of two master equations for two moduli functions, when λi 2 = 1/2 for ϵ = -1. A set of bounds on gravitational mass and scalar charge are presented by using a certain conjecture on parameters of solutions, when 1 + 2λi 2ϵ &gt; 0, i = 1, 2. © The Authors, published by EDP Sciences, 2018

The orbital stability of a test body motion in the field of two massive bodies

We investigate the orbital stability of a test particle motion in the restricted three-body problem where all bodies have their own rotation. We have shown that it is possible to get some insight into the stability properties of the motion of test particles in restricted three-body problem, without knowing the exact solutions of the relativistic motion equations. © The Authors, published by EDP Sciences, 2018

Dilatonic dyon black hole solutions in the model with two Abelian gauge fields

Dilatonic black hole dyon-like solutions in the gravitational 4d model with a scalar field, two 2-forms, two dilatonic coupling constants λi = 0, i = 1,2, obeying λ1 = - λ2 and sign parameter ϵ = ±1 for scalar field kinetic term are considered. Here ϵ = -1 corresponds to ghost scalar field. These solutions are defined up to solutions of two master equations for two moduli functions, when λi 2 = 1/2 for ϵ = -1. A set of bounds on gravitational mass and scalar charge are presented by using a certain conjecture on parameters of solutions, when 1 + 2λi 2ϵ &gt; 0, i = 1, 2. © The Authors, published by EDP Sciences, 2018