Perancangan Hotel & Convention Hall Universitas Muhammadiyah Surakarta Dengan Pendekatan Arsitektur Tropis

Universitas Muhammadiyah Surakarta (UMS) is one of 170 Muhammadiyah Universities (PTM) in Indonesia. UMS is located in the District of Kartasura, Sukoharjo. UMS implements "Scientific and Islamic Discourse" which is able to foster an Islamic culture that masters knowledge and skills that are based on Islamic values. Muhammadiyah University of Surakarta has a system of 2 graduations the first is a graduation department with a scale of one department and the second is a university graduation with a large scale of one university. From these 2 big events, students who need buildings that can help graduation programs majors. Surakarta Muhammadiyah University does not yet have public facilities that can support these activities. For writers who write basic architectural planning and design programs (DP3A) with the aim of: 1) Meeting the needs of a temporary resting place for tourists and families of graduates who are traveling or coming to the Solo City. 2) Design a representative building in the form of a comfortable Hotel & Meeting Hall and in accordance with the principles of Tropical Architecture. 3) Increase employment in the area. 4) Adding new fields of study in hospitality. 5) Facilitating academic, non-academic and conference activities as appropriate accommodations. The method used in the design of this concept is to collect data, data processing methods and at the end of the formulation of a concept. The UMS Hotel & Convention Hall as a supporting building for campus and public academic activities will be very helpful for participants of the Muhammadiyah Surakarta University budget increase program outside the campus. The design of this building has a concept of Tropical Architecture that is adapted to the comfort of the Tropical city of Surakarta

Direct Sensing of Endothelial Oxidants by Vascular Endothelial Growth Factor Receptor-2 and c-Src

BACKGROUND: ADPH oxidase-derived reactive oxygen species (ROS) play important roles in redox homeostasis and signal transduction in endothelial cells (ECs). We previously demonstrated that c-Src plays a key role in VEGF-induced, ROS-dependent selective activation of PI3K-Akt but not PLCγ-1-ERK1/2 signaling pathways. The aim of the present study was to understand how VEGFR-2-c-Src signaling axis 'senses' NADPH oxidase-derived ROS levels and couples VEGF activation of c-Src to the redox state of ECs. METHODOLOGY/PRINCIPAL FINDINGS: Using biotinylated probe that detects oxidation of cysteine thiol (cys-OH) in intracellular proteins, we demonstrate that VEGF induced oxidative modification in c-Src and VEGFR-2, and that reduction in ROS levels using siRNA against p47(phox) subunit of Rac1-dependent NADPH oxidase inhibited this phenomenon. Co-immunoprecipitation studies using human coronary artery ECs (HCAEC) showed that VEGF-induced ROS-dependent interaction between VEGFR-2 and c-Src correlated with their thiol oxidation status. Immunofluorescence studies using antibodies against internalized VEGFR-2 and c-Src demonstrated that VEGF-induced subcellular co-localization of these tyrosine kinases were also dependent on NADPH oxidsase-derived ROS. CONCLUSION/SIGNIFICANCE: These results demonstrate that VEGF induces cysteine oxidation in VEGFR-2 and c-Src in an NADPH oxidase-derived ROS-dependent manner, suggesting that VEGFR-2 and c-Src can 'sense' redox levels in ECs. The data also suggest that thiol oxidation status of VEGFR-2 and c-Src correlates with their ability to physically interact with each other and c-Src activation. Taken together, these findings suggest that prior to activating downstream c-Src-PI3K-Akt signaling pathway, VEGFR-2-c-Src axis requires an NADPH oxidase-derived ROS threshold in ECs

Assessment of Food Safety Knowledge, Attitudes and Practices of Food Service Staff in Bangladeshi Hospitals: A Cross-Sectional Study.

Food safety knowledge, attitudes and practices among hospital food service staff are crucial in the prevention of foodborne disease outbreaks, as hospitalized patients are more vulnerable to potential hazards. This study, therefore, sought to assess the food safety knowledge, attitudes and practices of food service staff in Bangladeshi hospitals. A cross-sectional study was conducted among 191 food service staff from seven different hospitals in Dhaka and Chattogram from October 2021 to March 2022 using pretested questionnaires. Multiple linear regression was used to identify the factors associated with the food safety knowledge, attitudes and practices. The findings showed moderate knowledge but high levels of attitudes and practices of food safety among hospital food handlers. Food safety knowledge was significantly higher among males, participants from private hospitals and participants working in a hospital that had a food service supervisor and dietitian in charge of food service operations. Moreover, participants from private hospitals and participants working in a hospital that had a food service supervisor and dietitian in charge of food service operations had more positive attitudes and better practices regarding food safety. Hospital management should consider these factors for enhancing food handlers' knowledge and increase training and supervision on food safety practices to reduce foodborne diseases and outbreaks

Survival of atraumatic restorative treatment (ART) sealants and restorations: a meta-analysis

The purpose of this study is to perform a systematic investigation plus meta-analysis into survival of atraumatic restorative treatment (ART) sealants and restorations using high-viscosity glass ionomers and to compare the results with those from the 2005 ART meta-analysis. Until February 2010, four databases were searched. Two hundred four publications were found, and 66 reported on ART restorations or sealant survival. Based on five exclusion criteria, two independent reviewers selected the 29 publications that accounted for the meta-analysis. Confidence intervals (CI) and or standard errors were calculated and the heterogeneity variance of the survival rates was estimated. Location (school/clinic) was an independent variable. The survival rates of single-surface and multiple-surface ART restorations in primary teeth over the first 2 years were 93% (CI, 91–94%) and 62% (CI, 51–73%), respectively; for single-surface ART restorations in permanent teeth over the first 3 and 5 years it was 85% (CI, 77–91%) and 80% (CI, 76–83%), respectively and for multiple-surface ART restorations in permanent teeth over 1 year it was 86% (CI, 59–98%). The mean annual dentine lesion incidence rate, in pits and fissures previously sealed using ART, over the first 3 years was 1%. No location effect and no differences between the 2005 and 2010 survival rates of ART restorations and sealants were observed. The short-term survival rates of single-surface ART restorations in primary and permanent teeth, and the caries-preventive effect of ART sealants were high. Clinical relevance: ART can safely be used in single-surface cavities in both primary and permanent teeth. ART sealants have a high caries preventive effect

Effect of Different Processing Stages on the Crystallinity % and Tensile Strength of 100% Cotton Fabric

In this study, 100 % cotton fabric was used to check the impact on fabric crystallinity and tensile strength at different processing stages. Desizing, scouring, bleaching, mercerization, and resin (only resin & resin+softener) application were the processes performed on the fabric. X-Ray diffractometer and tensile strength tester were used to determine the crystallinity index (CI) and tensile strength, respectively. Results revealed that from scouring to mercerization crystallinity (CI) decreased while desizing and resin application treatments showed no significant impact on the crystallinity (CI). In case of tensile strength, a decreasing trend from desizing to resin application was observed