FORMULATION AND OPTIMIZATION OF PIOGLITAZONE SOLID DISPERSIONS PREPARED BY HOT MELT EXTRUSION TECHNIQUE

The main objective of the present study was to develop a novel and stable pioglitazone loaded solid dispersions with enhanced solubility and dissolution rate. Different drug-to-carrier ratios were prepared by employing hot melt extrusion technique. These formulations were characterized for solid state properties by differential scanning calorimetry, X-ray powder diffraction and FT-IR spectral studies. Formulations were further evaluated for dissolution and stability studies. The aqueous solubility of pioglitazone, in present formulation was improved by the presence of both the polymers. Solid-state characterization indicated pioglitazone was present as amorphous material in formulation with Soluplus and polyethylene glycol, due to efficient entrapment in polymer matrix. The diffraction patterns of solid dispersion indicated the amorphous nature of pioglitazone in solid dispersions. The dissolution rate of all the solid dispersions was found to be rapid when compared to pure pioglitazone. Pioglitazone in pure form has very slow dissolution rate, when compared with the solid dispersions. Thus the solid dispersion prepared with Soluplus and polyethylene glycol would be useful for delivering poorly soluble pioglitazone with enhanced solubility and dissolution rate.Key words: pioglitazone, soluplus, solid dispersions, melt extrusion technique

Improving the US healthcare system: Lessons from Italy

The United States healthcare system is of crucial importance in today's economy. While many plausible solutions have been suggested to aid in the reduction of climbing costs, no clear answer exists. Comparing the US system with that of another country provides the opportunity to highlight assets, flaws, and variances that may otherwise be overlooked. Italy was ranked second in a 2000 health systems study by the World Health Organization (the most recent ranking available), while the US was ranked 37th. Thus, the potential exists to identify lessons for the US from the Italian healthcare system. We conduct a quantitative gap analysis of US and Italian healthcare system statistics. Publicly available data were used, through careful searches of online databases and websites, academic journals, healthcare literature, and government publications. Specific areas of interest in the gap analysis are the social impact of each country's healthcare system, the importance or obsolescence of information technology, and user satisfaction versus expenditure. Our results underline strengths and weaknesses of the United States healthcare system, which may be useful in predicting and preparing for the future

FORMULATION AND OPTIMIZATION OF PIOGLITAZONE SOLID DISPERSIONS PREPARED BY HOT MELT EXTRUSION TECHNIQUE

The main objective of the present study was to develop a novel and stable pioglitazone loaded solid dispersions with enhanced solubility and dissolution rate. Different drug-to-carrier ratios were prepared by employing hot melt extrusion technique. These formulations were characterized for solid state properties by differential scanning calorimetry, X-ray powder diffraction and FT-IR spectral studies. Formulations were further evaluated for dissolution and stability studies. The aqueous solubility of pioglitazone, in present formulation was improved by the presence of both the polymers. Solid-state characterization indicated pioglitazone was present as amorphous material in formulation with Soluplus and polyethylene glycol, due to efficient entrapment in polymer matrix. The diffraction patterns of solid dispersion indicated the amorphous nature of pioglitazone in solid dispersions. The dissolution rate of all the solid dispersions was found to be rapid when compared to pure pioglitazone. Pioglitazone in pure form has very slow dissolution rate, when compared with the solid dispersions. Thus the solid dispersion prepared with Soluplus and polyethylene glycol would be useful for delivering poorly soluble pioglitazone with enhanced solubility and dissolution rate

REVIEW ON DESIGN AND DEVELOPMENT OF FLOOR CLEANING MACHINE

This paper focuses more on Automation of Drainage waste removal equipment. There is a problem of blockage of drainage, to overcome this problem automation of the system is necessary. Our concept is to use this in an efficient way to removal of solid wastages from the water. The system only requires water flow to operate the turbine. In this paper we working on improving the drainage system of the small town through the comparative study of the different open drainage system. https://journalnx.com/journal-article/2015074

REVIEW ON DESIGN AND DEVELOPMENT OF FLOOR CLEANING MACHINE

Cleaning has become a basic need for all human beings and it is unavoidable in daily routine process. It is necessary to keep our environment clean because we get fresh air from our society and near around surrounding. In our project machine is designed in a such way that which will operate on mechanical energy and there no any use of electrical or any other energy sources. The motion is transmitted to scrubber from the wheels of the machine through the simple gear train. The dust or garbage is collected in compartment which is easy to remove from machine. It is the better alternative for conventional machine

Review On Design And Development Of Floor Cleaning Machine

Cleaning has become a basic need for all human beings and it is unavoidable in daily routine process. It is necessary to keep our environment clean because we get fresh air from our society and near around surrounding. In our project machine is designed in a such way that which will operate on mechanical energy and there no any use of electrical or any other energy sources. The motion is transmitted to scrubber from the wheels of the machine through the simple gear train. The dust or garbage is collected in compartment which is easy to remove from machine. It is the better alternative for conventional machine