Relações sociais e autopercepção da saúde: projeto envelhecimento e saúde Social relations and self- rated health: the ageing and health project

OBJETIVO: Investigar a associação entre as relações sociais e a autopercepção da saúde em idosos. MÉTODOS: Estudo transversal de amostra representativa de idosos cobertos pelo Programa de Saúde da Família e residentes em uma área de alta vulnerabilidade para a saúde em Belo Horizonte, MG. As informações foram obtidas por meio de entrevista estruturada. Idosos que relataram autopercepção ruim ou muito ruim da saúde foram comparados aos demais e os fatores associados foram determinados por meio de regressão logística múltipla. RESULTADOS: 363 dos 371 idosos elegíveis participaram do estudo. A autopercepção ruim da saúde foi relatada por 17,1% dos idosos e foi positivamente associada com o número de doenças crônicas e o grau de dificuldade para realizar as atividades de vida diária, apresentando um gradiente dose resposta. Idosos com auto-avaliação negativa dos relacionamentos pessoais e que não podiam contar com alguém caso ficassem acamados tiveram mais chance de autoperceber sua saúde como ruim. Trabalhar foi associado negativamente com a autopercepção ruim da saúde. CONCLUSÃO: Os resultados encontrados corroboram a estrutura multidimensional da autopercepção da saúde englobando fatores sociodemográficos, aspectos relacionados à saúde e às relações sociais e reforçam o papel dessas últimas sobre a saúde.<br>OBJECTIVE: To investigate the association between social relationships and self-perceived health in the elderly. METHODS: cross-sectional study of a representative sample of elderly individuals covered by the Family Health Program and residents in an area of high health vulnerability in Belo Horizonte, MG. Information was obtained through structured interviews. Factors associated with poor or very poor self-perceived health were identified by multiple logistic regression analysis. RESULTS: 363 out of 371 eligible elderly participated; 17.1% of elderly self-perceived their health as poor. There was a positive dose-response relationship between poor self-perceived health and the number of chronic diseases and the degree of difficulty to perform daily life activities. Elderly individuals who perceived their personal relationships as bad and who could not count on anyone if they became bedridden were more likely to self-rate their health as poor. Working was negatively associated with self-perceived poor health. CONCLUSION: The results confirm the multidimensional structure of self-perceived health including the issues related to health and social relationships. Our results strengthen the role of social relations on health

Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells

The fetal midbrain is a preferred source for isolating and producing dopaminergic neurons for subsequent grafting and replacement of damaged or lost dopaminergic midbrain neurons. We analysed the potential of a variety of nucleotides and of adenosine to support dopaminergic neuron formation from primary mouse fetal midbrain-derived cells, harvested at E10.5 and at E13.5 and subjected to adherent cell culture. In contrast to cells derived at E13.5, cells derived at E10.5 have the potential to produce dopaminergic neurons in culture. These neurons express tyrosine hydroxylase and the dopamine transporter. The fetal ventral midbrain contained mRNA encoding almost all P2X and P2Y receptors, all adenosine receptors as well as the ectonucleotidases nucleoside triphosphate diphosphohydrolase 2 and tissue nonspecific alkaline phosphatase. Essentially, all components of the purinergic signalling pathway were also expressed by the cultured cells. ATP, ADPβS, 2MeSATP, 2ClATP and adenosine increased neuron formation. There was, however, no preference for the formation of dopaminergic neurons—with the exception of 2ClATP that increased the relative contribution of tyrosine hydroxylase-positive neurons. In cells isolated at E13.5 UTP promoted neuron survival but ADPβS and ATPγS essentially eliminated neurons. These data showed that the outcome of nucleotide application was different even though cells isolated at E10.5 and E13.5 expressed very similar receptor mRNA profiles. They suggest that purinergic agonists carry potential for stimulating neurogenesis and enriching the contribution of dopaminergic neurons in vitro. Nucleotide receptor agonists may be of value for contributing to the formation and survival of dopaminergic neurons in vivo

Французский язык

Пособие состоит из 7 разделов, первые 5 из которых включают необходимый грамматический материал для продуктивного усвоения и завершаются тренировочными упражнениями и заданиями. В разделе 6 размещены ключи к тренировочным упражнениям и заданиям; раздел 7 содержит примерный контрольный лексико-грамматический тест, ключи к нему и шкалу оценки результатов выполнения теста. Практикум по дисциплине «Иностранный язык» для студентов экономических специальностей заочной формы обучения