Controlling the Big Stick: Theodore Roosevelt and theCuban Crisis of 1906

Theodore Roosevelt is unquestionably one of the giants of American political history. A veritable dynamo both in and out of office, Roosevelt was nothing less than a turn-of-the-century Renaissance man who combined a scholar\u27s keen intellect with a rough-and-tumble spirit of adventure. As this Nation\u27s twenty-sixth President, Roosevelt may be best remembered for developing his own corollary to James Monroe\u27s famous doctrine of 1823 and then using American military muscle to bring its tenets to life

Stabilized Singlets in Supergravity as a Source of the mu-parameter

Within the context of supergravity-coupled supersymmetry, fields which are gauge and global singlets are usually considered anathema. Their vacuum expectation values are shifted by quadratically divergent tadpole diagrams which are cutoff at the Planck scale, destabilizing the classical potential and driving the singlet field to large values. We demonstrate a new and generic mechanism which stabilizes the singlet in the presence of an extended gauge symmetry. Such a symmetry will be broken down to the Standard Model by the supergravity interactions near the scale of spontaneous supersymmetry-breaking in the hidden-sector (about 10^{10-11} GeV). The resulting singlet expectation value is stabilized and naturally of order the gravitino mass, providing therefore a weak-scale mass for the Higgs fields of the supersymmetric Standard Model (a "mu-parameter"). The resulting low-energy theory is the minimal supersymmetric Standard Model, with all new fields decoupling at the intermediate scale.Comment: 9 pages, LaTe

Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures

Niemann-Pick Type C disease (NPC) is a rare genetic disorder of lipid metabolism. A parameter related to horizontal saccadic peak velocity was one of the primary outcome measures in the clinical trial assessing miglustat as a treatment for NPC. Neuropathology is widespread in NPC, however, and could be expected to affect other saccadic parameters. We compared horizontal saccadic velocity, latency, gain, antisaccade error percentage and self-paced saccade generation in 9 adult NPC patients to data from 10 age-matched controls. These saccadic measures were correlated with appropriate MRI-derived brain structural measures (e.g., dorsolateral prefrontal cortex, frontal eye fields, supplemental eye fields, parietal eye fields, pons, midbrain and cerebellar vermis) and with measures of disease severity and duration. The best discriminators between groups were reflexive saccade gain and the two volitional saccade measures. Gain was also the strongest correlate with disease severity and duration. Most of the saccadic measures showed strongly significant correlations with neurophysiologically appropriate brain regions. While our patient sample is small, the apparent specificity of these relationships suggests that as new diagnostic methods and treatments become available for NPC, a broader range of saccadic measures may be useful tools for the assessment of disease progression and treatment efficacy.No external funding was received for this study. JCLL self-funded computational, travel and accommodation costs to conduct his component of this research in Melbourne

Referrals for suspected hematologic malignancy: A survey of primary care physicians

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91356/1/23172_ftp.pd

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Mutations in the gene encoding DNA methyltransferase 3A

Practical lessons learned for assessing and treating bipolar disorder via telehealth modalities during the COVID-19 pandemic

We briefly frame challenges and steps to overcoming those challenges in delivering care for patients with bipolar disorder via telehealth or telephone during COVID-19. Telehealth provides an invaluable opportunity to provide care for patients even under circumstances of social isolation. The issues discussed in this debate are intended to guide and assist clinicians, both in assessment and intervention, in adjusting to the use of virtual care for patients with bipolar disorder