Effectiveness of E-Advertising through Social Media Networks in Saudi Arabia

Online advertisement has been characterized as one of the most rapidly growing phenomena on the internet compared to traditional advertisement.  Furthermore, the wide spread of social media, which have fascinated hundreds of millions of users, has made online advertisement encounter numerous types of challenges.  Therefore, this study is conducted to analyze the effectiveness of electronic promotional advertising in social media in the Kingdom of Saudi Arabia. It aims to identify the effects of advertisements and the recommendations of friends via social media (Face book, Twitter, YouTube, LinkedIn and Instagram) on users' purchasing behavior.  This study has followed the descriptive and survey methodology by designing a questionnaire that has been refereed and tested for validity and reliability; then published through email groups in Saudi Arabia. A total of 133 valid responses have been received. One of the outcomes of this study indicated that the majority of users of the subject sample reinforced the influence of advertisements and friends’ recommendations in social media on drawing their attention and increasing their intention to make purchases.   Furthermore, the study recommends that businesses should benefit from social media in their promotion campaigns and closely pay attention to what customers exchange in social media regarding products and services. Keywords:  E-advertisement, Facebook, Friends’ recommendations, Purchasing behavior, Social media, Twitter.

A First Order Non-Stationary Seasonal Autoregressive Model With a Random Coefficient Parameter

This research aims to study a first-order seasonal autoregressive model with a random parameter taking different formulas and following the effect of the season on this parameter, assuming that the random errors of the model follows a standard normal distribution. Samples were selected (30, 60, 150, 240) and season lengths (4, 12) and the experiment was repeated 5000 times. One of the main findings is that the value of MSE decreases when increases in sample size and length of the season. Also, it is possible to estimate the parameter value of the model by traditional methods, even if it is a random coefficient. It is also noticed that the model (6) has the lowest MSE value for all sample sizes and different season lengths. Keywords: Non-Stationary, Autoregressive Model, Seasonal, Random Coefficient,  Exact Likelihood Metho

Determine the most important factors affecting breast cancer in Iraq

Today cancer is one of the diseases leading to death in the world in general and in the Middle East in particular, according to the reports of the World Health Organization. In spite of this, early detection through the availability of the necessary data on the disease in patients and the variety of variables studied helps in the large percentage of treatment, and that Increasing awareness among members of the Iraqi community, especially women, about breast cancer, proves its ability to recover from this disease through early and periodic examination and self-examination, and it was found that the number of injuries in terms of ages was for the second category (70-40), and this indicates that menstruation or what is known as the stage of hope is the stage that females must do early and periodic examination of this disease, and that the diagnosis of the disease was a clinical test or tissue culture, and therefore it was recommended to spread awareness for early and self-examination to detect the disease early and this greatly helps for treatment, with changing the data registration form for this type of disease to include more important variables, especially the genetic factor variable

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis.

Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed. The novel antifungal APX001A targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of APX001A against A. fumigatus and the in vivo activity of its prodrug APX001 in an immunosuppressed mouse model of IPA. APX001A inhibited the growth of A. fumigatus with a minimum effective concentration of 0.03 μg/ml. The use of 50 mg/kg 1-aminobenzotriazole (ABT), a suicide inhibitor of cytochrome P450 enzymes, enhanced APX001A exposures (area under the time-concentration curve [AUC]) 16- to 18-fold and enhanced serum half-life from ∼1 to 9 h, more closely mimicking human pharmacokinetics. We evaluated the efficacy of APX001 (with ABT) in treating murine IPA compared to posaconazole treatment. Treatment of mice with 78 mg/kg once daily (QD), 78 mg/kg twice daily, or 104 mg/kg QD APX001 significantly enhanced the median survival time and prolonged day 21 postinfection overall survival compared to the placebo. Furthermore, administration of APX001 resulted in a significant reduction in lung fungal burden (4.2 to 7.6 log10 conidial equivalents/g of tissue) versus the untreated control and resolved the infection, as judged by histopathological examination. The observed survival and tissue clearance were comparable to a clinically relevant posaconazole dose. These results warrant the continued development of APX001 as a broad-spectrum, first-in-class treatment of invasive fungal infections

Detection P53, Rb1 and H-ras Loss of Heterozygosity LOH in Patients with Urinary Bladder carcinoma

In this study 22 samples of urine sediments were obtained from patients with Urinary Bladder Carcinoma, DNA base technique and LOH detection was investigated in three genes P53, Rb1 and H-ras. The result are shown that LOH was present in most cases and for all genes where LOH in P53 represents (31.8%) and for Rb1 (45.4%) and for H-ras gene (27.2%).In some cases, more than one gene locus mutations were found

Bacteriological and immunological study associated with patients of Urinary Bladder carcinoma

The blood, serum & urine samples are collected from (22) patients with urinary bladder cancer were admitted to Al-Hilla general teaching hospital after diagnosis by helping urology physician. The result appeared that E.coli with high percentage (22.7% ,27.2%)in nixed &single infection respectively followed by Ps.aeuroginosa (22.7% , 13.6%) and S.aureus (18.8% , 9.09%).   Interleukin 2 &Interleukin 8 concentration level was detected in serum by enzyme-linked immunosorbent assay(ELISA) and data were compared with control to compare the performance of each cytokins & results show no elevated , no significant decrease in level  in two cytokins, this leads  to an independent factors for the detection of urinary bladder cancer

Constraints on Phases of Supersymmetric Flavour Conserving Couplings

In the unconstrained MSSM, we reanalyze the constraints on the phases of supersymmetric flavour conserving couplings that follow from the electron and neutron electric dipole moments (EDM). We find that the constraints become weak if at least one exchanged superpartner mass is >O(1 TeV) or if we accept large cancellations among different contributions. However, such cancellations have no evident underlying symmetry principle. For light superpartners, models with small phases look like the easiest solution to the experimental EDM constraints. This conclusion becomes stronger the larger is the value of $\tan\beta$. We discuss also the dependence of $\epsilon_K$, $\Delta m_B$ and $b\to s\gamma$ decay on those phases.Comment: 38 pages, 22 figures, uses epsfig.sty, axodraw.sty (not included); error in sign of gluino contribution to EDM of u and d quarks and few figures corrected, important conclusions unchange

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis.

There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001) in immunosuppressed murine models of hematogenously disseminated fusariosis and pulmonary scedosporiosis. The MGX minimum effective concentration (MEC) for Scedosporium isolates was 0.03 μg/ml and ranged from 0.015 to 0.03 μg/ml for Fusarium isolates. In the scedosporiosis model, treatment of mice with 78 mg/kg and 104 mg/kg of body weight fosmanogepix, along with 1-aminobenzotriazole (ABT) to enhance the serum half-life of MGX, significantly increased median survival time versus placebo from 7 days to 13 and 11 days, respectively. Furthermore, administration of 104 mg/kg fosmanogepix resulted in an ∼2-log10 reduction in lung, kidney, or brain conidial equivalents/gram tissue (CE). Similarly, in the fusariosis model, 78 mg/kg and 104 mg/kg fosmanogepix plus ABT enhanced median survival time from 7 days to 12 and 10 days, respectively. A 2- to 3-log10 reduction in kidney and brain CE was observed. In both models, reduction in tissue fungal burden was corroborated with histopathological data, with target organs showing reduced or no abscesses in fosmanogepix-treated mice. Survival and tissue clearance were comparable to a clinically relevant high dose of liposomal amphotericin B (10 to 15 mg/kg). Our data support the continued development of fosmanogepix as a first-in-class treatment for infections caused by these rare molds

Phytochemistry and Ethnopharmacology of Some Medicinal Plants Used in the Kurdistan Region of Iraq.

The majority of Kurds inhabit a region that includes adjacent parts of Iran, Iraq, Syria and Turkey. This review shows that the traditional medicine is still used by Kurdish peoples and underlines the medicinal value of a great number of plants used locally. The medicinal uses include the treatment of a variety of diseases, ranging from simple stomach-ache to highly complicate male and female disorders; even sexual weakness and kidney stones are treated by plants. The majority of the plants that are used are for curing gastro-intestinal disorders and inflammation, followed by urinary tract disorders, skin burns, irritations and liver problems. In the last part of this paper, we also report the first results of our ongoing research project on the constituents of some uninvestigated Kurdish medicinal plants. The C-glycosylflavone embinin, the α-methylene acyl derivative 6-tuliposide A, and the iridoids aucubin and ajugol were isolated for the first time from Iris persica, Tulipa systole and Verbascum calvum, respectively. These plants are traditionally used against inflammation, pain, and skin burns