Perdagangan dan Kerjasama Ekonomi Dalam Ekonomi Sirkular

Perubahan paradigma dari ekonomi linear ke ekonomi sirkular membuka peluang besar dalam mengurai permasalahan lingkung�an, sosial dan sumberdaya ekonomi berbasis nilai tambah. Dengan paradigma prinsip CE peluang perdagangan internasional dan kerjasama antar negara sangat terbuka, apalagi negara-negara diberbagai kawasan, baik Barat, Eropa, Timur Tengah, dan bahkan Asia menjanjikan. Hal yang perlu dilakukan pemerintah Indonesia saat ini tentu perlu membuat kebijakan yang mendorong dan keberpihakan pada pengolahan (remanufakturing) limbah industri dan perumahan yang ramah lingkungan supaya bernilai ekonomis, serta pengawasan yang ketat pada para pelaku usaha agar kesada�ran akan manfaatnya ekonomi sirkular berkelanjutan

Analysis of Factors Affecting State Revenue Receipts From the Taxation Sector

State revenues reflected in the APBN can be understood as total state financial revenues. This study aims to describe state revenues from the tax sector. The research method uses explanations from secondary data sources, especially from BPS. The conclusion obtained is that domestic tax revenues sourced from income tax, value added tax and income tax on luxury goods, land and building taxes, excise and other taxes have a direct effect on state financial revenues. The second international trade tax still does not make a significant contribution even though the import duty tax revenue is quite good, and the export tax is still not significant. The contribution of overall tax revenue in Indonesia to state finances is very high

Islamic Micro financial Institution in Distributing Productive Financing to SMEs

Proper funding is one of the biggest problems faced by micro and small entrepreneurs. Funding or Capital financing is usually very limited. Meanwhile, existing banking institutions including shari'a banking initiate various requirements so complicated for micro and small-enterprises/SMEs to attain. The existence of shari'a microfinance institutions which are currently in the form of BMTs can be found in almost every village or small town. BMT, as part of shari'a coordination, is a microfinance institution that plays a role as a banking institution, i.e. collecting, distributing and providing services can be an alternative for micro and small entrepreneurs. BMT as a companion institution for the distribution of SMEs would be the right partner, compared to banking institutions. Thus, it is expected that BMT as a shari’a cooperative or microfinance institution has to improve its performance. In exchange, the empowerment of micro and small businesses through financial assistance can be effective, especially in terms of funding management, membership and financing must be continuously improved

Knowing the Figure of KH. Munawar Al Badri Sang Paku Bumi, Da'wah Fighters from the North Coast

Every struggle of the ulama/kyai must have obstacles, obstacles and challenges, although relatively different but in principle the same, namely amar ma'rûf nahy munkar. KH. Munawar bin Kyai Badriyah bin Kyai Sarbian the originator and initiator of Islamic syi'ar broadcasters in the past Grinting era (1965s) known as Grinting is a black of culture, the village was left behind after being made aware of the importance of education, especially religious education in the 20s years later now different, advanced, high achievers and religious. It even became the village with the best educational participation rate. Through a qualitative approach with a narrative model and historical, descriptive, and literature methods. Success in spreading the mission of Islamic boarding school with its three teaching materials, namely reading the Qur'an, understanding tajwid and having good morals contributed to the millennial era, including in initiating Jam'iyah, and madrasa education

Influence of Clinical Pathway Implementation on the Outcome of Drug Rehabilitation Program Services

Patient safety, quality, and efficiency are global issues, therefore hospitals must be able to apply clinical pathways through clinical pathways as the main facilities and infrastructure, especially in services for increasingly acute drug addicts. This study aims to analyze the implementation of clinical pathways for drug rehabilitation program outcomes on 1) clinical quality, 2) cost, 3) readmission, 4) satisfaction, and 5) LOS, at RSJD Atma Husada Mahakam. This type of research uses cross-sectional with observational analytic, data collection through distributing questionnaires to 111 respondents, observation and literature study. The results showed that the clinical quality before and after the implementation of the clinical pathway had a significant effect, but the cost of treatment did not show any significance. There is a positive relationship between readmission and the implementation of clinical pathways, as well as addict satisfaction in the LOS rehabilitation room has a significant effect on treatment time and clinical pathways. A recommendation that the 5 (five) variables mentioned above, apart from being cost-effective, can improve the quality of drug rehabilitation services at RSJD Atma Husada Mahakam Samarinda, so it needs to be maintaine

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

Approximately 80% of patients diagnosed with acute myeloid leukemia (AML) die as a consequence of failure to eradicate the tumor from the bone marrow microenvironment. We have recently shown that stroma-derived interleukin-8 (IL-8) promotes AML growth and survival in the bone marrow in response to AML-derived macrophage migration inhibitory factor (MIF). In the present study we show that high constitutive expression of MIF in AML blasts in the bone marrow is hypoxia-driven and, through knockdown of MIF, HIF1α and HIF2α, establish that hypoxia supports AML tumor proliferation through HIF1α signaling. In vivo targeting of leukemic cell HIF1α inhibits AML proliferation in the tumor microenvironment through transcriptional regulation of MIF, but inhibition of HIF2α had no measurable effect on AML blast survival. Functionally, targeted inhibition of MIF in vivo improves survival in models of AML. Here we present a mechanism linking HIF1α to a pro-tumoral chemokine factor signaling pathway and in doing so, we establish a potential strategy to target AML

Trend and status of air quality at three different monitoring stations in the Klang Valley, Malaysia

Over the last decades, the development of the Klang Valley (Malaysia), as an urban commercial and industrial area, has elevated the risk of atmospheric pollutions. There are several significant sources of air pollutants which vary depending on the background of the location they originate from. The aim of this study is to determine the trend and status of air quality and their correlation with the meteorological factors at different air quality monitoring stations in the Klang Valley. The data of five major air pollutants (PM10, CO, SO2, O3, NO2) were recorded at the Alam Sekitar Sdn Bhd (ASMA) monitoring stations in the Klang Valley, namely Petaling Jaya (S1), Shah Alam (S2) and Gombak (S3). The data from these three stations were compared with the data recorded at Jerantut, Pahang (B), a background station established by the Malaysian Department of Environment. Results show that the concentrations of CO, NO2 and SO2 are higher at Petaling Jaya (S1) which is due to influence of heavy traffic. The concentrations of PM10 and O3, however, are predominantly related to regional tropical factors, such as the influence of biomass burning and of ultra violet radiation from sunlight. They can, though, also be influenced by local sources. There are relatively stronger inter-pollutant correlations at the stations of Gombak and Shah Alam, and the results also suggest that heavy traffic flow induces high concentrations of PM10, CO, NO2 and SO2 at the three sampling stations. Additionally, meteorological factors, particularly the ambient temperature and wind speed, may influence the concentration of PM10 in the atmosphere

Microarray analysis revealed different gene expression patterns in HepG2 cells treated with low and high concentrations of the extracts of Anacardium occidentale shoots

In this study, the effects of low and high concentrations of the Anacardium occidentale shoot extracts on gene expression in liver HepG2 cells were investigated. From MTT assays, the concentration of the shoot extracts that maintained 50% cell viability (IC50) was 1.7 mg/ml. Cell viability was kept above 90% at both 0.4 mg/ml and 0.6 mg/ml of the extracts. The three concentrations were subsequently used for the gene expression analysis using Affymetrix Human Genome 1.0 S.T arrays. The microarray data were validated using real-time qRT–PCR. A total of 246, 696 and 4503 genes were significantly regulated (P < 0.01) by at least 1.5-fold in response to 0.4, 0.6 and 1.7 mg/ml of the extracts, respectively. Mutually regulated genes in response to the three concentrations included CDKN3, LOC100289612, DHFR, VRK1, CDC6, AURKB and GABRE. Genes like CYP24A1, BRCA1, AURKA, CDC2, CDK2, CDK4 and INSR were significantly regulated at 0.6 mg/ml and 1.7 mg but not at 0.4 mg/ml. However, the expression of genes including LGR5, IGFBP3, RB1, IDE, LDLR, MTTP, APOB, MTIX, SOD2 and SOD3 were exclusively regulated at the IC50 concentration. In conclusion, low concentrations of the extracts were able to significantly regulate a sizable number of genes. The type of genes that were expressed was highly dependent on the concentration of the extracts used

Impact of the frequency of online verifications on the patient set-up accuracy and set-up margins

<p>Abstract</p> <p>Purpose</p> <p>The purpose of the study was to evaluate the patient set-up error of different anatomical sites, to estimate the effect of different frequencies of online verifications on the patient set-up accuracy, and to calculate margins to accommodate for the patient set-up error (ICRU set-up margin, SM).</p> <p>Methods and materials</p> <p>Alignment data of 148 patients treated with inversed planned intensity modulated radiotherapy (IMRT) or three-dimensional conformal radiotherapy (3D-CRT) of the head and neck (n = 31), chest (n = 72), abdomen (n = 15), and pelvis (n = 30) were evaluated. The patient set-up accuracy was assessed using orthogonal megavoltage electronic portal images of 2328 fractions of 173 planning target volumes (PTV). In 25 patients, two PTVs were analyzed where the PTVs were located in different anatomical sites and treated in two different radiotherapy courses. The patient set-up error and the corresponding SM were retrospectively determined assuming no online verification, online verification once a week and online verification every other day.</p> <p>Results</p> <p>The SM could be effectively reduced with increasing frequency of online verifications. However, a significant frequency of relevant set-up errors remained even after online verification every other day. For example, residual set-up errors larger than 5 mm were observed on average in 18% to 27% of all fractions of patients treated in the chest, abdomen and pelvis, and in 10% of fractions of patients treated in the head and neck after online verification every other day.</p> <p>Conclusion</p> <p>In patients where high set-up accuracy is desired, daily online verification is highly recommended.</p