Crosstalk and the Dynamical Modularity of Feed-Forward Loops in Transcriptional Regulatory Networks

Network motifs, such as the feed-forward loop (FFL), introduce a range of complex behaviors to transcriptional regulatory networks, yet such properties are typically determined from their isolated study. We characterize the effects of crosstalk on FFL dynamics by modeling the cross regulation between two different FFLs and evaluate the extent to which these patterns occur in vivo. Analytical modeling suggests that crosstalk should overwhelmingly affect individual protein-expression dynamics. Counter to this expectation we find that entire FFLs are more likely than expected to resist the effects of crosstalk (approximate to 20% for one crosstalk interaction) and remain dynamically modular. The likelihood that cross-linked FFLs are dynamically correlated increases monotonically with additional crosstalk, but is independent of the specific regulation type or connectivity of the interactions. Just one additional regulatory interaction is sufficient to drive the FFL dynamics to a statistically different state. Despite the potential for modularity between sparsely connected network motifs, Escherichia coli (E. coli) appears to favor crosstalk wherein at least one of the cross-linked FFLs remains modular. A gene ontology analysis reveals that stress response processes are significantly overrepresented in the cross-linked motifs found within E. coli. Although the daunting complexity of biological networks affects the dynamical properties of individual network motifs, some resist and remain modular, seemingly insulated from extrinsic perturbations-an intriguing possibility for nature to consistently and reliably provide certain network functionalities wherever the need arise

Dynamic Voltage Scaling Techniques for Energy Efficient Synchronized Sensor Network Design

Building energy-efficient systems is one of the principal challenges in wireless sensor networks. Dynamic voltage scaling (DVS), a technique to reduce energy consumption by varying the CPU frequency on the fly, has been widely used in other settings to accomplish this goal. In this paper, we show that changing the CPU frequency can affect timekeeping functionality of some sensor platforms. This phenomenon can cause an unacceptable loss of time synchronization in networks that require tight synchrony over extended periods, thus preventing all existing DVS techniques from being applied. We present a method for reducing energy consumption in sensor networks via DVS, while minimizing the impact of CPU frequency switching on time synchronization. The system is implemented and evaluated on a network of 11 Imote2 sensors mounted on a truss bridge and running a high-fidelity continuous structural health monitoring application. Experimental measurements confirm that the algorithm significantly reduces network energy consumption over the same network that does not use DVS, while requiring significantly fewer re-synchronization actions than a classic DVS algorithm.unpublishedis peer reviewe

A hybrid neuro--wavelet predictor for QoS control and stability

For distributed systems to properly react to peaks of requests, their adaptation activities would benefit from the estimation of the amount of requests. This paper proposes a solution to produce a short-term forecast based on data characterising user behaviour of online services. We use \emph{wavelet analysis}, providing compression and denoising on the observed time series of the amount of past user requests; and a \emph{recurrent neural network} trained with observed data and designed so as to provide well-timed estimations of future requests. The said ensemble has the ability to predict the amount of future user requests with a root mean squared error below 0.06\%. Thanks to prediction, advance resource provision can be performed for the duration of a request peak and for just the right amount of resources, hence avoiding over-provisioning and associated costs. Moreover, reliable provision lets users enjoy a level of availability of services unaffected by load variations

Efficient computation of min and max sensor values in multihop networks

Consider a wireless sensor network (WSN) where a broadcast from a sensor node does not reach all sensor nodes in the network; such networks are often called multihop networks. Sensor nodes take sensor readings but individual sensor readings are not very important. It is important however to compute aggregated quantities of these sensor readings. The minimum and maximum of all sensor readings at an instant are often interesting because they indicate abnormal behavior, for example if the maximum temperature is very high then it may be that a fire has broken out. We propose an algorithm for computing the min or max of sensor readings in a multihop network. This algorithm has the particularly interesting property of having a time complexity that does not depend on the number of sensor nodes; only the network diameter and the range of the value domain of sensor readings matter

Improving Energy Conservation Using Bulk Transmission over High-Power Radios in Sensor Networks

International audienceLow power radios, such as the CC2420, have been widely popular with recent sensor platforms. This paper ex- plores the potential for energy savings from adding a high- power, high-bandwidth radio to current sensor platforms. High-bandwidth radios consume more power but signifi- cantly reduce the time for transmissions. Consequently, they offer net savings in total communication energy when there is enough data to offset wake-up energy overhead. The analysis on energy characteristics of several IEEE 802.11 radios show that a feasible crossover point exists (in terms of data size) after which energy savings are possible. Based on this analysis, we present a bulk data transmission proto- col for dual radio systems. The results of simulations and prototype implementation show significant energy savings at the expense of introducing acceptable delay