Morphology Under Control: Engineering Biodegradable Stomatocytes

Biodegradable nanoarchitectures, with well-defined morphological features, are of great importance for nanomedical research; however, understanding (and thereby engineering) their formation is a substantial challenge. Herein, we uncover the supramolecular potential of PEG-PDLLA copolymers by exploring the physicochemical determinants that result in the transformation of spherical polymersomes into stomatocytes. To this end, we have engineered blended polymersomes (comprising copolymers with varying lengths of PEG), which undergo solvent-dependent reorganization inducing negative spontaneous membrane curvature. Under conditions of anisotropic solvent composition across the PDLLA membrane, facilitated by the dialysis methodology, we demonstrate osmotically induced stomatocyte formation as a consequence of changes in PEG solvation, inducing negative spontaneous membrane curvature. Controlled formation of unprecedented, biodegradable stomatocytes represents the unification of supramolecular engineering with the theoretical understanding of shape transformation phenomena

A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement

Contains fulltext : 166222.pdf (publisher's version ) (Open Access

Micro- and nano-motors for biomedical applications

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Asymmetric catalysis in polymersome nanoreactors

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Aqueous asymmetric cyclopropanation reactions in polymersome membranes

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Polymersomes as a potential platform for cancer immunotherapy

With the focus in the field of cancer nanomedicine shifting from direct tumor targeting to modulation of the immune system, new opportunities arise for the employment of nanocarrier systems. Polymeric nanovesicles, or polymersomes, have been under investigation as a potential nanocarrier platform for the past decades. These investigations have enhanced our fundamental knowledge on how to tailor physicochemical properties, such as size and shape, surface chemistry and functionalization, and membrane characteristics. The versatile nature and high structural stability of polymersomes makes them suitable for cancer treatment that goes beyond drug delivery. Rational nanocarrier design allows for the spatiotemporal control over the function of specific immune cell targets to enhance cancer immunotherapy. This review provides a perspective view on the potential of polymersomes as a multifunctional platform for in vivo cancer immunotherapy. We discuss opportunities to implement polymersomes in the field, elaborate on their design considerations for immunotherapeutic applications and compare polymersomes with lipid nanoparticles and other relevant systems. Current challenges and future perspectives are addressed to underline what is needed to employ polymersomes as a platform for cancer immunotherapy

Polymersome magneto-valves for reversible capture and release of nanoparticles

Contains fulltext : 133223.pdf (publisher's version ) (Open Access

Mimicking the Cell: Bio-lnspired Functions of Supramolecular Assemblies

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Nanoreactors for green catalysis

Contains fulltext : 200714.pdf (publisher's version ) (Open Access

Profiling anthropometric characteristics and functional performance of 12 to 18-year-old elite junior soccer players

Etude des équipes nationales juniors par des mesures anthropométriques et des tests de condition physique, de puissance musculaire et de motricité spécifiqu