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Abdelmohsen, L.K.E.A.

Hest, J. van

Huck, W.T.S.

Nijemeisland, M.

Wilson, D.A.

PubMed

Every
living cell is a compartmentalized out-of-equilibrium system
exquisitely able to convert chemical energy into function. In order
to maintain homeostasis, the flux of metabolites is tightly controlled
by regulatory enzymatic networks. A crucial prerequisite for the development
of lifelike materials is the construction of synthetic systems with
compartmentalized reaction networks that maintain out-of-equilibrium
function. Here, we aim for autonomous movement as an example of the
conversion of feedstock molecules into function. The flux of the conversion
is regulated by a rationally designed enzymatic reaction network with
multiple feedforward loops. By compartmentalizing the network into
bowl-shaped nanocapsules the output of the network is harvested as
kinetic energy. The entire system shows sustained and tunable microscopic
motion resulting from the conversion of multiple external substrates.
The successful compartmentalization of an out-of-equilibrium reaction
network is a major first step in harnessing the design principles
of life for construction of adaptive and internally regulated lifelike
systems

Marlies Nijemeisland (1420321)

Loai K. E. A. Abdelmohsen (1420315)

Wilhelm T. S. Huck (1292637)

Daniela A. Wilson (1420312)

Jan C. M. van Hest (1420303)

FigShare

A Compartmentalized Out-of-Equilibrium Enzymatic Reaction
Network for Sustained Autonomous Movement

Every living cell is a compartmentalized out-ofequilibrium system exquisitely able to convert chemical energy into function. In order to maintain homeostasis, the flux of metabolites is tightly controlled by regulatory enzymatic networks. A crucial prerequisite for the development of lifelike materials is the construction of synthetic systems with compartmentalized reaction networks that maintain out-of-equilibrium function. Here, we aim for autonomous movement as an example of the conversion of feedstock molecules into function. The flux of the conversion is regulated by a rationally designed enzymatic reaction network with multiple feedforward loops. By compartmentalizing the network into bowl-shaped nanocapsules the output of the network is harvested as kinetic energy. The entire system shows sustained and tunable microscopic motion resulting from the conversion of multiple external substrates. The successful compartmentalization of an out-of-equilibrium reaction network is a major first step in harnessing the design principles of life for construction of adaptive and internally regulated lifelike systems

van Hest, J.C.M.

NARCIS 

A compartmentalized out-of-equilibrium enzymatic reaction network for sustained autonomous movement

\u3cp\u3eEvery living cell is a compartmentalized out-ofequilibrium system exquisitely able to convert chemical energy into function. In order to maintain homeostasis, the flux of metabolites is tightly controlled by regulatory enzymatic networks. A crucial prerequisite for the development of lifelike materials is the construction of synthetic systems with compartmentalized reaction networks that maintain out-of-equilibrium function. Here, we aim for autonomous movement as an example of the conversion of feedstock molecules into function. The flux of the conversion is regulated by a rationally designed enzymatic reaction network with multiple feedforward loops. By compartmentalizing the network into bowl-shaped nanocapsules the output of the network is harvested as kinetic energy. The entire system shows sustained and tunable microscopic motion resulting from the conversion of multiple external substrates. The successful compartmentalization of an out-of-equilibrium reaction network is a major first step in harnessing the design principles of life for construction of adaptive and internally regulated lifelike systems.\u3c/p\u3

Nijemeisland, Marlies

Abdelmohsen, LKEA

Huck, Wilhelm T S

Wilson, DA

Hest, JCM Jan  van

Repository TU/e

Marlies Nijemeisland

Loai K. E. A. Abdelmohsen

Wilhelm T. S. Huck

Daniela A. Wilson

Jan C. M. van Hest

Crossref

ACS Central Science

A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement

Radboud Repository

Every living cell is a compartmentalized out-ofequilibrium system exquisitely able to convert chemical energy into function. In order to maintain homeostasis, the flux of metabolites is tightly controlled by regulatory enzymatic networks. A crucial prerequisite for the development of lifelike materials is the construction of synthetic systems with compartmentalized reaction networks that maintain out-of-equilibrium function. Here, we aim for autonomous movement as an example of the conversion of feedstock molecules into function. The flux of the conversion is regulated by a rationally designed enzymatic reaction network with multiple feedforward loops. By compartmentalizing the network into bowl-shaped nanocapsules the output of the network is harvested as kinetic energy. The entire system shows sustained and tunable microscopic motion resulting from the conversion of multiple external substrates. The successful compartmentalization of an out-of-equilibrium reaction network is a major first step in harnessing the design principles of life for construction of adaptive and internally regulated lifelike systems.</p

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A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement

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